Protamine sulfate Rx

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Protamine sulfate

Only 4 drugs may be compared at once

Generic Name and Formulations:

Protamine sulfate 10mg/mL; soln for inj; preservative-free.

Select therapeutic use:

Indications for Protamine sulfate:

Treatment of heparin overdose.


Give by slow IV inj over 10 mins. Determine dose by coagulation studies; dose requirement decreases with time elapsed after heparin administration. 1mg neutralizes ≥100units of heparin; max 50mg/dose.


Not recommended.


Avoid rapid administration. Fish allergy. Previous exposure to protamine (including insulin). Severe left ventricular dysfunction. Abnormal pulmonary hemodynamics. Previous vasectomy. Pregnancy (Cat.C). Nursing mothers.


Incompatible with certain antibiotics (eg, cephalosporins, penicillins).

Pharmacological Class:

Heparin antagonist.

Adverse Reactions:

Hypotension, bradycardia, transient flushing, feeling of warmth, dyspnea, GI upset, lassitude, pulmonary edema, anaphylaxis, cardiovascular collapse, pulmonary vasoconstriction, pulmonary hypertension.

How Supplied:

Vial (5mL)—25; 25mL—1