Poisoning/overdose

Investigational Tx Shows Promise in Chronic Low Back Pain

By September 19, 2018

An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.

CroFab Labeling Updated With Extended Shelf Life, Removal of Mercury Warning

By September 13, 2018

CroFab is a sheep-derived antivenin indicated for the management of adult and pediatric patients with North American crotalid (rattlesnakes, copperheads, cottonmouths/water moccasins) envenomation.

Naloxone Rarely Administered by Layperson in Opioid Deaths

September 10, 2018

In 44% of the deaths, bystanders were reportedly present, but naloxone was rarely administered by a layperson.

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

By August 31, 2018

The new plan will break out the current guidance into 4 separate guidances.

Drinking Water Turned Off in All Detroit's Public Schools

August 31, 2018

Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.

Chronic Vaping Exerts Biological Effects on Lungs

August 29, 2018

Approximately 300 proteins were differentially expressed in epithelial cells from biopsy samples in smoker and vaper airways, only 78 proteins were commonly altered in both groups, and 113 were uniquely altered in vapers.

FDA Bans E-Cig Liquid Products That Look Like Snacks, Candies

August 24, 2018

Labels and ads for the nicotine-containing e-liquids were false or misleading, and potentially dangerous

Odds of Death Up With Exposure to Pregabalin, Opioids

August 21, 2018

Dose-response association with highest odds of opioid-related death with high-dose prefabbing

Midlife Deaths Increase in the United States

August 20, 2018

The researchers found that all-cause mortality increased among non-Hispanic (NH) whites, NH American Indians, and Alaskan Natives.

QI Program Can Up Outcomes for Neonatal Abstinence Syndrome

August 20, 2018

The researchers observed significant decreases in pharmacologic treatment (from 87.1 to 40%), adjunctive agent use (from 33.6 to 2.4%), hospitalization length of stay (from 17.4 to 11.3 days), and opioid treatment days (from 16.2 to 12.7).

CDC: EMS Administration of Naloxone Up From 2012 to 2016

August 13, 2018

This increase mirrored the 79.7% increase in opioid overdose mortality from 7.4 (deaths per 100,000 persons) to 13.3.

CDC: Use of Unapproved Opioid-Like Antidepressant on the Rise in the US

By August 07, 2018

While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

July 25, 2018

"Although stroke and dementia were both associated with late-onset epilepsy, vascular and lifestyle risk factors were significant even in the absence of stroke or dementia," the authors write.

<i>Salmonella</i> Spurs Recall of Ritz Crackers

July 24, 2018

No illnesses associated with the recalled Ritz products have been reported, according to the New Jersey-based company.

Harmful Internet "Challenges" and Teens: A Guide for Primary Care Providers

July 12, 2018

Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.

Misleading Popular Videos Impact Attitudes About Tobacco

July 11, 2018

"In the context of our findings, young adults should be trained in identifying and resisting contents that appear on social media, but share many of the characteristics of peer pressure to use unhealthy products," the authors write.

High Rates of <i>Salmonella</i> Contamination ID'd in Kratom

July 10, 2018

Of 81 samples of kratom collected for testing, 42 (52%) were contaminated with Salmonella, indicating that a high proportion of kratom being shipped into the United States may be contaminated.

Cannabis Use Prevalence Up Across Adult Age Groups

June 26, 2018

No significant differences in increases were seen across adult ages 18 to 64 years; the increases ranged between 1 and 2 percentage points.

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

June 25, 2018

The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children 6 years old and unintentional. However, the majority of exposures among adolescents aged 13 to 19 years were intentional and more commonly involved multiple substances.

Risk of OD Highest for First Days of Opioid &#43; Benzodiazepine Use

June 25, 2018

The highest risk of overdose was seen on the first days of concurrent opioid and benzodiazepine use, with a decrease in risk over time.

Insurance Company Sets Goal for Reducing Opioid Overdoses by 25%

By June 22, 2018

Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

June 21, 2018

Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.

CDC: Salmonella-Tainted Melon Outbreak Continues to Expand

June 21, 2018

Of the 63 patients with available information who became ill between, 34 have been hospitalized. No deaths have been reported. Illnesses have been reported in Illinois (7), Indiana (11), Kentucky (1), Michigan (38), Missouri (10), Ohio (2), and Tennessee (1).

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

June 20, 2018

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

CDC: Many High School Students Engage in Health-Risk Behaviors

June 19, 2018

Many high school students were engaged in behaviors associated with chronic disease; 8.8% had smoked cigarettes and 13.2% had used an electronic vapor product on at least 1 day during the past 30 days.

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

By June 14, 2018

A significant decrease in the patient's serum VPA concentration was observed following the first dose of meropenem as well as over the next 14 hours (to 36.5mg/mL). Additionally, the patient was reported to become more alert despite increased serum ammonia levels.

Sixty Sickened so Far in Salmonella-Tainted Melon Outbreak

June 14, 2018

Of the 60 patients who became ill between April 30, 2018, and May 30, 2018, 31 have been hospitalized. The patients range in age from 1 to 97 years.

Older Age, ICU, Poor Renal Fcn Up Risk of Opioid OD in Hospital

June 13, 2018

The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.

Kitchen Towels Are Source of Possibly Pathogenic Bacteria

June 12, 2018

Compared with single-use towels, multipurpose towels had higher colony-forming units (CFUs); humid towels had higher CFUs than dry ones. The mean CFU was 2.76 × 105, and was significantly higher from cotton versus nylon and mixture of both towels.

Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion

By June 11, 2018

Noting that infants and children who ingest button batteries can experience esophageal damage leading to significant morbidity and death in as little as 2 hours, researchers from the Children's Hospital of Philadelphia and Nationwide Children's Hospital aimed to identify effective options for mitigating these effects by testing common weakly acidic household beverages, viscous liquids, and sucralfate (Carafate).