An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.
CroFab is a sheep-derived antivenin indicated for the management of adult and pediatric patients with North American crotalid (rattlesnakes, copperheads, cottonmouths/water moccasins) envenomation.
Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.
Approximately 300 proteins were differentially expressed in epithelial cells from biopsy samples in smoker and vaper airways, only 78 proteins were commonly altered in both groups, and 113 were uniquely altered in vapers.
The researchers observed significant decreases in pharmacologic treatment (from 87.1 to 40%), adjunctive agent use (from 33.6 to 2.4%), hospitalization length of stay (from 17.4 to 11.3 days), and opioid treatment days (from 16.2 to 12.7).
While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.
"Although stroke and dementia were both associated with late-onset epilepsy, vascular and lifestyle risk factors were significant even in the absence of stroke or dementia," the authors write.
Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.
"In the context of our findings, young adults should be trained in identifying and resisting contents that appear on social media, but share many of the characteristics of peer pressure to use unhealthy products," the authors write.
Of 81 samples of kratom collected for testing, 42 (52%) were contaminated with Salmonella, indicating that a high proportion of kratom being shipped into the United States may be contaminated.
No significant differences in increases were seen across adult ages 18 to 64 years; the increases ranged between 1 and 2 percentage points.
The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children 6 years old and unintentional. However, the majority of exposures among adolescents aged 13 to 19 years were intentional and more commonly involved multiple substances.
The highest risk of overdose was seen on the first days of concurrent opioid and benzodiazepine use, with a decrease in risk over time.
Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.
Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.
Of the 63 patients with available information who became ill between, 34 have been hospitalized. No deaths have been reported. Illnesses have been reported in Illinois (7), Indiana (11), Kentucky (1), Michigan (38), Missouri (10), Ohio (2), and Tennessee (1).
Many high school students were engaged in behaviors associated with chronic disease; 8.8% had smoked cigarettes and 13.2% had used an electronic vapor product on at least 1 day during the past 30 days.
A significant decrease in the patient's serum VPA concentration was observed following the first dose of meropenem as well as over the next 14 hours (to 36.5mg/mL). Additionally, the patient was reported to become more alert despite increased serum ammonia levels.
Of the 60 patients who became ill between April 30, 2018, and May 30, 2018, 31 have been hospitalized. The patients range in age from 1 to 97 years.
The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.
Compared with single-use towels, multipurpose towels had higher colony-forming units (CFUs); humid towels had higher CFUs than dry ones. The mean CFU was 2.76 × 105, and was significantly higher from cotton versus nylon and mixture of both towels.
Noting that infants and children who ingest button batteries can experience esophageal damage leading to significant morbidity and death in as little as 2 hours, researchers from the Children's Hospital of Philadelphia and Nationwide Children's Hospital aimed to identify effective options for mitigating these effects by testing common weakly acidic household beverages, viscous liquids, and sucralfate (Carafate).