Poisoning & Drug Dependence

FDA Ad Campaign Hopes to Halt E-Cigarette Use Among Teens

September 19, 2018

In addition, the FDA wants to be sure young people are aware that e-cigarettes can contain dangerous chemicals such as acrolein, a chemical that can cause irreversible lung damage; formaldehyde, a cancer-causing chemical; and toxic metal particles like chromium, lead and nickel, which can be inhaled into the lungs.

Many Older Adults Transition to Long-Term Benzodiazepine Use

September 14, 2018

The researchers found that 26.4% of adults met the definition of long-term use 1 year after the index prescription; they were prescribed a mean of 232.7 benzodiazepine days.

CroFab Labeling Updated With Extended Shelf Life, Removal of Mercury Warning

By September 13, 2018

CroFab is a sheep-derived antivenin indicated for the management of adult and pediatric patients with North American crotalid (rattlesnakes, copperheads, cottonmouths/water moccasins) envenomation.

FDA Gets Tough on Juul, Other Electronic Cigarette Makers

September 13, 2018

All of these brands - JUUL, Vuse, MarkTen, blu e-cigs, and Logic - made up the majority of products sold illegally to minors, the agency said.

Cassipa Approved as Maintenance Treatment for Opioid Dependence

By September 10, 2018

Cassipa combines buprenorphine, an opioid (partial agonist-antagonist), and naloxone, an opioid antagonist.

Naloxone Rarely Administered by Layperson in Opioid Deaths

September 10, 2018

In 44% of the deaths, bystanders were reportedly present, but naloxone was rarely administered by a layperson.

Designer opioid receptor agonist provides pain relief without side effects

September 08, 2018

Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia, dependence, and abuse.

With New Persistent Opioid Use, Most Early Scripts From Surgeons

September 07, 2018

But in the longer term, the majority of opioid prescriptions come from primary care physicians

Anti-Nicotine Monoclonal Antibody Gets Orphan Drug Status for Buerger's Disease

By September 05, 2018

Buerger's disease is a nonatherosclerotic, segmental inflammatory disorder that affects small and medium vessels of the upper and lower extremities and is strongly associated with tobacco exposure.

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

By August 31, 2018

The new plan will break out the current guidance into 4 separate guidances.

Drinking Water Turned Off in All Detroit's Public Schools

August 31, 2018

Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.

Chronic Vaping Exerts Biological Effects on Lungs

August 29, 2018

Approximately 300 proteins were differentially expressed in epithelial cells from biopsy samples in smoker and vaper airways, only 78 proteins were commonly altered in both groups, and 113 were uniquely altered in vapers.

Marijuana Detected in Breast Milk Up to 6 Days After Maternal Use

By August 28, 2018

The legalization of marijuana in several states has led to increased use of the drug for both medicinal and recreational purposes.

E-cigarette use common, especially among younger adults and the LBGTQ community

August 28, 2018

Adults within the LBGTQ community more likely to use e-cigarettes. 2. Participants with chronic health conditions and current combustible cigarette smokers also had higher rates of e-cigarette use.

One in 7 US adults used marijuana in 2017

August 28, 2018

Adults aged 18 to 34 had the highest frequency of marijuana use compared to all other age groups.

Prevalence of E-Cigarette Use 4.5% in US Adults

August 28, 2018

The researchers found that 15,240 of the 466,842 participants with information on e-cigarette use were current e-cigarette smokers, a prevalence of 4.5%, which corresponds to 10.8 million adult users in the United States.

Odds of Marijuana Use Up With Nausea, Vomiting in Pregnancy

August 27, 2018

The prevalence of prenatal marijuana use was 5.3% by self-report or toxicologic test findings; prevalence was greater among females with severe and mild versus no NVP (11.3 and 8.4, respectively, vs 4.5%).

FDA Bans E-Cig Liquid Products That Look Like Snacks, Candies

August 24, 2018

Labels and ads for the nicotine-containing e-liquids were false or misleading, and potentially dangerous

Information Lacking on Effect of Prenatal Use of Marijuana

August 23, 2018

Large retrospective, prospective trials are needed to understand effects of prenatal exposure

Studies needed to determine the effects of marijuana use in pregnancy

August 21, 2018

Pregnant women who screened positive for marijuana often also tested positive for at least 1 other substance.

Odds of Death Up With Exposure to Pregabalin, Opioids

August 21, 2018

Dose-response association with highest odds of opioid-related death with high-dose prefabbing

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

By August 20, 2018

Last year, the DEA proposed a 20% reduction in the manufacturing of controlled substances for 2018 compared to 2017.

Midlife Deaths Increase in the United States

August 20, 2018

The researchers found that all-cause mortality increased among non-Hispanic (NH) whites, NH American Indians, and Alaskan Natives.

QI Program Can Up Outcomes for Neonatal Abstinence Syndrome

August 20, 2018

The researchers observed significant decreases in pharmacologic treatment (from 87.1 to 40%), adjunctive agent use (from 33.6 to 2.4%), hospitalization length of stay (from 17.4 to 11.3 days), and opioid treatment days (from 16.2 to 12.7).

Integration of Opioid, Infectious Disease Treatment Needed

August 15, 2018

"All health care providers have a role in combating the OUD epidemic and its infectious disease consequences. Those who treat infectious complications of OUD are well-suited to screen for OUD and begin treatment with effective US Food and Drug Administration-approved medications," the authors write.

CDC: EMS Administration of Naloxone Up From 2012 to 2016

August 13, 2018

This increase mirrored the 79.7% increase in opioid overdose mortality from 7.4 (deaths per 100,000 persons) to 13.3.

AMA Calls for Greater Electronic Cigarette Regulation

August 07, 2018

The AMA is urging the federal government to move quickly to regulate e-cigarettes and require manufacturers to list the ingredients and nicotine content clearly on product labels, as well as a warning of the addictive quality of nicotine.

CDC: Use of Unapproved Opioid-Like Antidepressant on the Rise in the US

By August 07, 2018

While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Lucemyra Now Available for Mitigation of Opioid Withdrawal Symptoms

By August 06, 2018

Lucemyra is not indicated as a treatment for opioid use disorder.

Can E-Cigarettes Aid Smoking Cessation Efforts?

August 02, 2018

E-cigarette use was 9.8% among current smokers, 1.1% among former smokers, and 0.6% among nonsmokers.