Pharmacological Therapy

Aetna-CVS Merger Approved

October 11, 2018

The companies involved in these mergers say they will improve coordination of care for consumers, but critics say consumers could be left with far fewer choices and potentially higher costs.

Components of Pharmacist-Led Discharge Counseling Vary

September 25, 2018

Two differences were identified: the use of a dosage schedule, which was more frequent in studies published in 2011 or before and in studies outside the United States, and the teach-back technique, which was used more frequently in the United States.

AMA: PA Process Delays Care, Negatively Impacts Clinical Outcomes

March 20, 2018

According to the results of the survey, 64% of respondents reported waiting at least one business day for a PA decision from health plans, with 30% waiting at least three business days.

Have Recent Guidelines Reduced Inappropriate Antibiotic Prescribing?

March 19, 2018

The researchers found that during the 3-year study period, about 98 million outpatient antibiotic prescriptions were filled by 39 million insurance beneficiaries. Azithromycin, amoxicillin, amoxicillin/clavulanate, ciprofloxacin, and cephalexin were the most commonly prescribed antibiotics.

Most Physical Therapists Open To Integrated Model of Care With Pharmacists

March 13, 2018

One major reason reported for the lack of use was a perceived increase in workload (51%). Most respondents reported a positive perception of this model and interactions with pharmacists, and were also confident in their ability to safely recommend medication (63%).

Growing Pharmacist Burnout Needs To Be Addressed, Say Experts

February 22, 2018

Experts say strategies can be employed to help reduce stress while at the pharmacy; these include pharmacists taking a few minutes each day to talk to customers and refocus on why they chose this profession, as well as taking time for reflection before work or after the shift.

Automated Inventory System May Offer Time Savings for Pharmacists

February 20, 2018

Use of the technology at the Summa Health System-Barberton Campus in Ohio has been beneficial, saving time for pharmacists and technicians even though the amount of time savings has not been fully realized as use of the technology is in early phases.

The Major Challenges Facing Pharmacists in 2018

January 31, 2018

Drug affordability, nonadherence, and pharmacist compensation are major challenges for the year

ASHP Create New Forum to Provide 'Voice' for Practicing Technicians

December 07, 2017

The Pharmacy Technician Forum will provide necessary education, tools, and resources needed to advance the career paths of technicians and enhance their roles as members of the interprofessional patient care team.

ASHP: Immediate Action Needed From Congress on Drug Shortages

December 07, 2017

Specifically, the organizations provide a call to action for Congress to determine how manufacturers should handle disclosing drug shortages to the medical community.

In Children, Reduced Arousal Aggravates Respiratory Depression By Morphine

June 11, 2015

Reporting on a study of the reaction of children to morphine administration at SLEEP 2015, Gaspard Montandon, PhD, University of Toronto, said that respiratory depression was "more severe when patients were in states of reduced arousal due to the sedative properties of morphine."

How Does OSAS Severity Affect Glucose Tolerance?

June 11, 2015

Severe obstructive sleep apnea syndrome (OSAS) may potentially be associated with pancreatic β-cell functional disorder and glucagon-like peptide-1 (GLP-1) resistance, according to a study presented at SLEEP 2015.

Chew on This: Caffeine Gum Put to the Test in New Study

By June 11, 2015

Chewing caffeine gum for five minutes immediately upon awakening may counter sleep inertia, especially for reaction time, according to a data presented at SLEEP 2015.

Some Sedative Hypnotics Not Ideal for Predicting Low-Arousal Threshold

By June 11, 2015

Administration of a non-benzodiazepine sedative hypnotic (NBSH) does not increase the likelihood of having a low arousal phenotype for obstructive sleep apnea (OSA), a study presented at SLEEP 2015 has concluded.

Study: Suvorexant Improves Sleep, Daytime Functioning at Two Doses

June 11, 2015

The orexin receptor antagonist suvorexant improves sleep in patients with insomnia, analysis of pooled results of two Phase 3 clinical trials presented at SLEEP 2015 have found.

Lemborexant Shows Equivalent Efficacy in Men, Women With Insomnia

By June 11, 2015

Lemborexant (E2006), a dual orexin receptor antagonist (DORA) under development for insomnia disorder, led to a decrease in latency to persistent sleep (LPS) and wake after sleep onset (WASO) and an increase in sleep efficiency (SE), according to data presented at SLEEP 2015.

Sodium Oxybate Found to Improve Health-Related Quality of Life Measures

By June 11, 2015

Sodium oxybate improved health-related quality-of-life (HRQoL) measures in patients with narcolepsy in a dose-dependent manner, results from a randomized placebo-controlled trial presented at SLEEP 2015 have found.

Pharmacotherapy Improves Function in Patients With Narcolepsy in 'Real-World' Setting

By June 11, 2015

Pharmacotherapy improves multiple domains of functioning in patients with central disorders of hypersomnolence (CDH) in a "real-world" tertiary care setting, according to data presented at SLEEP 2015.

Flu Vaccine Triggers Status Cataplecticus in Teen With Narcolepsy

By June 11, 2015

A case study presented at SLEEP 2015 suggest that an influenza vaccination may have triggered status cataplecticus in the female patient with known narcolepsy.

SSRI Could Improve Sleep via Fibromyalgia Relief

By June 11, 2015

Milnacipran does not directly improve sleep continuity and architecture but its impact on sleep improvement can be attributed to its effectiveness in reducing pain, according to data presented at SLEEP 2015.

Longer Sleep May Have Protective Effect on Pain

By June 11, 2015

Endogenous pain regulatory function is impacted by sleep duration, according to data presented at SLEEP 2015,

Comparable Effects Seen With Zolpidem, Eszopiclone in PAP Titration

June 10, 2015

When eszopiclone was given instead of zolpidem, no difference was observed on the polysomnogram diagnostic and positive airway pressure (PAP)-titration portions, according to data reported at SLEEP 2015.

Case Study: New Onset Myasthenia Gravis and Narcolepsy With Cataplexy

By June 10, 2015

An 80-year-old male with new onset myasthenia gravis and narcolepsy with cataplexy had symptomatic improvement with sodium oxybate—but not with immune-modulating agents, results of a case study presented at SLEEP 2015 have shown.

Novel DORA Agent Promising As Insomnia Treatment

By June 10, 2015

E2006, a novel dual orexin receptor antagonist (DORA), has shown efficacy for both subject-reported sleep onset and maintenance on sleep diary measures, according to Phase 2 study results reported at SLEEP 2015.

Fewer Cognitive Effects Seen With Almorexant Than BZD Receptor Agonists

By June 10, 2015

Almorexant, a hypocretin receptor antagonist, produced fewer acute cognitive effects than the GABAA receptor modulator zolpidem, according to results of a randomized controlled trial presented at SLEEP 2015.

Two Gabapentin Enacarbil Doses Found to Reduce Pain, RLS Symptoms

By June 10, 2015

Treatment with gabapentin enacarbil at both the 600mg and 1200mg doses "led to a greater number of adult patients who met the criteria for a combined pain and International Restless Legs Scale (IRLS) total score response" compared to placebo, a study presented at SLEEP 2015 confirmed.

Factors Identified in Zolpidem Treatment Failure for Insomnia

By June 10, 2015

For about one-third of patients treated with zolpidem, only partial improvement is observed, researchers reported at SLEEP 2015.

Does Vitamin E Increase Memory Performance in Sleep-Deprived Patients?

June 09, 2015

Higher levels of vitamin E improve spatial memory performance in sleep-deprived women, according to data presented at SLEEP 2015.

Comparing the Effect of Suvorexant for Men and Women

By June 09, 2015

Suvorexant (Belsomra; Merck) 20mg/15mg and 40mg/30mg tablets were generally effective and well tolerated by both women and men with insomnia, according to a subgroup analysis of Phase 3 data presented at SLEEP 2015.

Patients, Docs Agree on Disease Status Change with Novel Narcolepsy Agent

By June 09, 2015

Clinician- and patient-reported assessments of global impression of change in disease status had "good concordance" for narcolepsy treated with JZP-110, a novel wake-promoting agent, according to results of a post hoc analysis reported at SLEEP 2015.