Pediatrics

Homeopathic Products for Teething, Nausea, Colic, Cough Recalled

By May 18, 2018

Recalled products include Teething Drops, Nausea Drops, Intestinal Colic Drops, Stomach Calm, Expectorant Cough Syrup, Silver-Zinc Throat Spray, and Argentum Elixir.

RA Treatment During Pregnancy: Is Infection Risk Greater in Offspring?

By May 18, 2018

Offspring were followed from birth until 12 months, first indication of serious infection, end of commercial insurance eligibility, death or end of study period, whichever came first.

Truvada Approved for HIV-1 Pre-Exposure Prophylaxis in At-Risk Adolescents

By May 17, 2018

The use of Truvada for PrEP in the adolescent population was based on a single-arm, open-label clinical study (ATN113) among 67 HIV-1 negative young men (aged 15 to 17 years) who have sex with men (YMSM).

Positive Results for Dupilumab in Teen Atopic Dermatitis Trial

By May 16, 2018

The primary endpoint was the proportion of patients with an IGA score of 0 (clear) or 1 (almost clear) at Week 16.

Suicide Ideation, Attempts Increasing Among US Children

May 16, 2018

The researchers identified 115,856 SI and SA encounters during the study period.

Prescription Med Use in Children Down Overall From 1999 to 2014

May 16, 2018

Asthma medications, antibiotics, attention-deficit/hyperactivity disorder (ADHD) medications, topical agents, and antihistamines were the most commonly used medication classes in 2011 to 2014.

FDA Fast-Tracks Treatment for Autism Spectrum Disorder

By May 15, 2018

There are currently no approved pharmacological treatments that address these core symptoms of ASD.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Peripheral Neuropathy Common in Childhood Cancer Survivors

May 15, 2018

Clinical abnormalities consistent with peripheral neuropathy were common and were observed in about half (50.5%) of those treated with neurotoxic chemotherapy

FDA Approves First MS Treatment for Pediatric Patients

By May 14, 2018

The FDA's decision was based on data from the Phase 3 PARADIGMS study (N=215) which evaluated the safety and efficacy of oral fingolimod vs interferon beta-1a injection in pediatric patients aged 10 to <18 years with relapsing MS.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

By May 14, 2018

The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Actemra SC Approved to Treat Rare Form of Juvenile Arthritis

By May 14, 2018

Approval of the SC formulation for this patient population was supported by data from the Phase 1b JIGSAW-117 trial, a 52-week, open-label multicenter, pharmacokinetic/pharmacodynamic bridging study (N=52) that aimed to determine the appropriate dosing regimen of Actemra SC based on body weight in children with PJIA.

Maternal Exposure to Polluted Air Tied to Elevated Child BP

May 14, 2018

The researchers found that when third trimester PM2.5 concentration was ≥13µg/m³, there was a sharp increase in offspring systolic blood pressure (SBP) percentile and risk for elevated BP.

Reported Cannabis Use Up in Parents With Children in Home

May 14, 2018

Data were obtained from the National Survey on Drug Use and Health from 2002 to 2015. The researchers did not have information on the method of cannabis use (ie, smoking versus edible forms).

Treatment for Rare Pediatric Cancer Granted Orphan Drug Designation

By May 10, 2018

CLR 131 is an investigational radioiodinated Phospholipid Drug Conjugate (PDC) drug candidate that delivers cytotoxic radiation directly and selectively to malignant cells.

Concerns Over EpiPen Supply Prompt Statement from Mylan

By May 09, 2018

Intermittent supply constraints due to manufacturing delays from Mylan's manufacturing partner, Meridian Medical Technologies, have resulted in varying supply levels.

Peds Fasting Duration Not Tied to Adverse Sedation Outcomes

May 09, 2018

A total of 6,183 children were included in the analysis; of these, 48.1 and 5% did not meet American Society of Anesthesiologists fasting guidelines for solids and liquids, respectively.

Exceptional Glycemic Control With Very Low-Carbohydrate Diet

May 09, 2018

The mean HbA1c was 5.67±0.66%. In the past year, only 2% of respondents reported diabetes-related hospitalizations, including 1% each for ketoacidosis and hypoglycemia.

Emergency Contraceptive Preventeza Now Available Over-the-Counter

By May 08, 2018

Preventeza can be taken within 72 hours of unprotected sex or contraceptive failure although it is most effective the sooner it is taken.

Teen Sexting Linked to Intimate Partner Violence, Sexual Abuse

May 08, 2018

Independent correlations for having sent a sext were seen for having been sexually abused, IPV perpetration, ever had sex.

Prevalence of Obese, Allergic Asthma Phenotypes Examined in US Children

By May 08, 2018

The study authors examined data obtained from the 2007-2008 National Survey of Children's Health (NSCH) to determine the prevalence, risk factors, as well as the severity of asthma phenotypes.

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

By May 07, 2018

The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.

Combo Therapy Appears Safe, Effective for Severe Inflammatory Acne

By May 07, 2018

Treatment with the combination gel + oral doxycycline was associated with a 66.2% reduction in inflammatory lesions, a 58.7% reduction in non-inflammatory lesions, and a 62.6% reduction in total lesions at Week 12 vs baseline (P <.0001).

Daily Sports Drink Consumption Down in US Teenagers

May 07, 2018

"Although daily consumption of sports drinks has decreased overall, sugar-sweetened sports drinks remain popular, with the majority of high school students drinking them at least weekly," the authors write.

Child Secondhand Pot &#43; Tobacco Exposure Ups Risk for ER Visits

May 07, 2018

The rate of emergency department visitation was similar for all groups, except the marijuana plus tobacco group, which had a significantly higher rate of emergency department visits compared with controls.

Executive Function Improved With Prenatal Exposure to SSRIs

May 07, 2018

The researchers found that even after controlling for MDS (prenatal and when child was age 12 years), maternal education, child's age, and verbal ability, children with pSRI performed better on the most demanding part of the Flanker/Reverse Flanker task.

Low Neighborhood Walkability Increases Risk of Asthma in Kids

May 07, 2018

There was an increased incidence of asthma among birth home neighborhoods with low walkability (hazard ratio, 1.11). Low walkability in a given year of a child's life was associated with greater odds of ongoing asthma in the same year (odds ratio, 1.12).

FDA Committees Vote Against Drug Tx for Severe Neonatal Jaundice

By May 04, 2018

Stannsoporfin, a heme oxygenase inhibitor, works by inhibiting bilirubin production at its source.

Most Concerning Med Issues Explored Among Youth With Asthma

By May 04, 2018

The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."

Unit-Dose Packaging Cuts Accidental Pediatric Opioid Exposures

May 04, 2018

Relative decrease in buprenorphine-naloxone exposure after transition to unit-dose packaging