What's New in Pain Management: New Medications, Drugs in the Pipeline
|The following article features coverage from PAINWeek 2017 in Las Vegas, Nevada. Click here to read more of MPR's conference coverage.|
LAS VEGAS — A program offered at PAINWeek 2017, held September 5-9, covered new medications that were introduced to the market or approved by the US Food and Drug Administration (FDA) in 2016 and 2017. The presenters were Mary Lynn McPherson, PharmD, a professor and executive director of the Advanced Post-Graduate Education in Palliative Care in the Department of Pharmacy Practice and Science at the University of Maryland School of Pharmacy, and Alexandra L. McPherson, PharmD, MPH, a postgraduate year 2 pharmacy practice resident there.1
They reviewed new drugs indicated for central nervous system and gastrointestinal disorders, infection, cancer treatment, and diabetes. Here are new agents they singled out, which are indicated for pain management:
Other new drugs of interest for pain practitioners include Vivlodex, a low-dose formulation of the nonsteroidal anti-inflammatory drug meloxicam for the management of osteoarthritis pain, and Intrarosa (prasterone), a vaginal insert to treat painful vaginal intercourse associated with menopause.
Also discussed was the first-in-class opioid analgesic NKTR-181, a long-acting, selective μ-opioid agonist that demonstrated positive top-line results for the treatment of chronic back pain, as announced in July 2017.3 It is designed to reduce adverse effects associated with opioids (eg, euphoria), which can lead to abuse and dependence.
In addition, the presenters reported that AceIRx Pharmaceuticals has submitted a new drug application for sublingual sufentanil, which is intended to provide relief within 15 minutes for moderate to severe acute pain. The drug would be administered in a clinical setting via a prefilled, single-dose applicator.
"We continue to develop abuse-deterrent opioid formulations, and I think the peripherally acting μ-opioid receptor antagonists continue to be pharmacologically very interesting," although both are associated with substantial cost, Dr McPherson told Clinical Pain Advisor. She noted that "pain and palliative care practitioners need to stay abreast of not only pain and palliative care drugs, but all new drugs, because they impact the entire medication regimen."
Read more of MPR's coverage of PAINWeek 2017 by visiting the conference page.
- McPherson ML, McPherson AL. New drugs in pain management and palliative care. Presented at PAINWeek 2017; September 5-9, 2017; Las Vegas, NV.
- Rosenthal RN, Lofwall MR, Kim S, Chen M, Beebe KL, Vocci FJ; PRO-814 Study Group. Effect of buprenorphine implants on illicit opioid use among abstinent adults with opioid dependence treated with sublingual buprenorphine: a randomized clinical trial. JAMA. 2016;316(3):282-290. doi: 10.1001/jama.2016.9382
- PR Newswire. Nektar announces topline data from human abuse potential study for NKTR-181, a first-in-class investigational opioid to treat chronic pain. 2017. Available at: http://www.prnewswire.com/news-releases/nektar-announces-topline-data-from-human-abuse-potential-study-for-nktr-181-a-first-in-class-investigational-opioid-to-treat-chronic-pain-300489675.html. Accessed September 6, 2017.