Pain Management

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Comparative Safety of NSAIDs Among Clopidogrel Users Investigated

By March 15, 2018

Using Medicaid claims from 5 states (1999-2010) and Medicare claims for dual-enrollees, study authors analyzed the first concomitant use of clopidogrel and 1 of 10 selected NSAIDs (ibuprofen, celecoxib, naproxen, rofecoxib, meloxicam, diclofenac, indomethacin, valdecoxib, nabumetone, etodolac) after a 1-year baseline period.

Virtual Reality Distraction May Help Reduce Procedural Pain

March 15, 2018

The researchers found that VR was effective for reducing procedural pain, even in patients subjected to extremely painful procedures, such as those with burn injuries undergoing wound care and physical therapy.

Peripheral Neuropathy Management: A Guide for Primary Care Clinicians

By March 14, 2018

Peripheral neuropathy is tied to significant morbidity and decrease in quality of life, therefore it is imperative to efficiently diagnosis.

Teens With Mental Health Conditions More Likely to Receive Opioids Long-Term

March 13, 2018

Teens with pre-existing mental health conditions, tx more likely to transition to long-term opioid use

Acupuncture for Treating Pain: Should It Be Recommended?

March 12, 2018

The reasons for and against recommending acupuncture for treating pain are discussed in a head-to-head article.

Opioid Rx Patterns Examined for Head and Neck, Lung and Colon Cancer

March 12, 2018

The researchers identified 168 prescriptions associated with HNCA and 571 with LCCA diagnoses. Compared to patients with LCCA, patients with HNCA had significantly increased odds of being prescribed an opioid (odds ratio, 1.68).

Excess Acetaminophen Intake, Overdosing Seen During Cold/Flu Season

By March 08, 2018

"This is the first multi-year, year-round study that includes detailed data on how consumers used acetaminophen medications," said Dr. Shiffman.

CDC: Increases in Opioid-Involved Overdoses in All Five U.S. Regions

March 07, 2018

Per quarter, this rate increased on average by 5.6%. Increases were seen in rates across demographic groups and all 5 U.S. regions; the largest increases were seen in the Southwest, Midwest, and West (about 7 to 11% per quarter).

Year-Long Study Assesses Opioid vs. Non-Opioid Tx for Back, Osteoarthritis Pain

March 07, 2018

The researchers observed no significant difference between the groups in pain-related function over 12 months (overall P=0.58); the mean 12-month Brief Pain Inventory (BPI) interference was 3.4 and 3.3 for the opioid and non-opioid groups, respectively.

Efforts to Reduce Adult Opioid Use Have Not Slowed Pediatric Ingestion

March 06, 2018

The researchers found that there were 3,647 opioid-related hospitalizations in 31 hospitals, of which 42.9% required PICU care. Overall mortality was 1.6%, with annual deaths decreasing from 2.8 to 1.3% over the study period (P<0.001).

Certain Factors May Increase the Likelihood of Gabapentin Overuse

By March 01, 2018

The likelihood of gabapentin overuse alone is low but increased significantly with concomitant opioid use.

Sublocade Now Available for Moderate-to-Severe Opioid Use Disorder

By March 01, 2018

Sublocade is intended for use as part of a complete treatment program that includes counseling and psychosocial support.

FDA to Review NDA for Opioid Analgesic Remoxy ER

By March 01, 2018

Remoxy ER is an abuse-deterrent, extended-release capsule formulation of oxycodone.

Change in Diet May Cut Pain Associated With Gluten Neuropathy

March 01, 2018

The researchers observed no significant differences in terms of age, gender, neuropathy severity, and neuropathy type for patients with painful and not painful gluten neuropathy.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

By February 28, 2018

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Migraine Treatment With Needle-Free Delivery System No Longer Available

By February 27, 2018

Both strengths of Sumavel DosePro have now been discontinued.

Serotonin Syndrome Risk Assessed With Concomitant Triptan, SSRI/SNRI Use

February 27, 2018

Researchers question FDA advisory warning on risk of concomitant use

Apadaz Approved for the Short-Term Treatment of Acute Pain

By February 23, 2018

Apadaz is an immediate-release combination of benzhydrocodone, a prodrug of hydrocodone, and acetaminophen (APAP).

Cardiovascular Risk Compared Among COX-2 Selective, Nonselective NSAIDs

By February 22, 2018

Results showed the crude hazard ratio (HR) of major cardiovascular events was 1.99 (95% CI, 1.28-3.09) for COX-2 vs. nonselective NSAIDs.

Study Belies Common Notion That Opioid Patients Fail Outpatient Tapers

February 21, 2018

The researchers found that 38% of the 82 enrolled patients did not complete a 4-month follow-up survey and were considered to have dropped out. There was a negative correlation for depression and a positive correlation for baseline marijuana use with study completion.

Does Hydroxychloroquine Improve Symptoms of Hand Osteoarthritis?

By February 20, 2018

Findings do not support the current practice of off-label use of hydroxychloroquine for treating symptomatic hand osteoarthritis.

Patients With Trigeminal Neuralgia Receive a Variety of Treatments

By February 15, 2018

A total of 3,685 trigeminal neuralgia patients were included for analysis.

Post-Op Analgesia Strategies Compared Following Scoliosis Surgery

February 15, 2018

In base-case analysis, use of opioids alone was both most costly and least effective, while opioids plus intravenous acetaminophen was intermediate in both cost and effectiveness, and opioids plus intravenous acetaminophen and ketorolac was the least expensive and most effective strategy.

Opioid Use May Increase the Risk for Invasive Pneumococcal Disease

February 13, 2018

Strongest associations seen for opioids that were long acting, of high potency, and used at high doses

Is Cranial Electrical Stimulation Effective for Pain, Depression, Anxiety?

February 13, 2018

In patients with anxiety and depression, low-strength evidence of a possible modest benefit was seen in 4 trials conducted more than 40 years ago and in one recent trial compared with sham treatments.

FDA Analysis Shows Kratom Not "Just a Plant"

By February 07, 2018

Kratom should not be used to treat medical conditions, nor should it be used as an alternative to prescription opioids.

Clinical Effects of Ketamine &#43; Propofol Examined for Ped MRI Sedation

February 07, 2018

The researchers found that the ketamine-propofol group experienced significantly shorter recovery times; 38 versus 54 minutes; median difference, 14 minutes; P<0.001.

Positive Results for Ubrogepant in Phase 3 Migraine Trial

By February 06, 2018

A total of 1,327 migraine patients were treated in the study for a single migraine attack. At 2 hours after migraine attack, 19.2% (n=423) and 21.2% (n=448) of ubrogepant 50mg and 100mg were pain free, respectively.