Pain Management

'Urgent' Need for Cannabinoid Trials in Ped Neurologic Disorders

September 21, 2018

Parents use unregulated cannabinoids to manage neurological disorders in children, including seizures, spasticity, and irritability in children with epilepsy, autism-spectrum disorder, and cerebral palsy.

Investigational Tx Shows Promise in Chronic Low Back Pain

By September 19, 2018

An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.

ZTlido Patch for Post-Shingles Pain Launching Soon

By September 19, 2018

The non-aqueous adhesive patch requires 36mg per topical system to achieve the same therapeutic dose as Lidoderm (lidocaine 5%) which contains 700mg per patch.

US Senate Passes Opioids Bill

September 19, 2018

Five different committees submitted more than 70 proposals to help craft the bill, called the Opioid Crisis Response Act of 2018.

FDA: Opioid Analgesic REMS Expanded to Include Immediate-Release Products

By September 18, 2018

As part of the REMS program, drug companies with approved opioid analgesics must make training available to prescribers and provide unrestricted grants to accredited continuing education providers for the development of education courses.

Many RA Patients' Pain Related to Central Nervous System

September 17, 2018

The investigators note that RA patients with increased levels of FMness seem to share neurobiologic features consistently observed in fibromyalgia patients.

Ajovy Injection Approved for Migraine Prevention in Adults

By September 17, 2018

The primary efficacy endpoint was the mean change from baseline in the monthly average number of headache days of at least moderate severity during the 3-month treatment period.

CDC: About 1 in 5 US Adults Have Chronic Pain

September 14, 2018

The prevalences of both chronic pain and high-impact chronic pain were higher among women; older adults; adults who were previously, but not currently, employed; adults living in poverty; those with public health insurance; and rural residents.

First-in-Class Non-Opioid for Post-Surgical Pain Gets Breakthrough Tx Designation

By September 12, 2018

CA-008 is given as a single local injection and works by selectively desensitizing pain-conducting nerve fibers without causing numbness or weakness

Cassipa Approved as Maintenance Treatment for Opioid Dependence

By September 10, 2018

Cassipa combines buprenorphine, an opioid (partial agonist-antagonist), and naloxone, an opioid antagonist.

Designer opioid receptor agonist provides pain relief without side effects

September 08, 2018

Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia, dependence, and abuse.

With New Persistent Opioid Use, Most Early Scripts From Surgeons

September 07, 2018

But in the longer term, the majority of opioid prescriptions come from primary care physicians

Cardiovascular Health Risks Identified With Diclofenac Use

By September 07, 2018

To investigate the cardiovascular risks associated with diclofenac, researchers conducted a series of cohort studies mimicking the design criteria of a clinical trial.

Hospital Groups Launch Own Generic Drug Company

September 07, 2018

The company, Civica Rx, will start with 14 widely used hospital drugs

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

By September 05, 2018

The investigators hope that the BCG vaccine can increase anti-inflammatory cytokines, which are deficient in patients with fibromyalgia.

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

By August 31, 2018

The new plan will break out the current guidance into 4 separate guidances.

Preemptive Analgesia May Cut Post-Op Pain in Anorectal Surgery

August 31, 2018

The researchers found that patients in the active group had significantly less pain in the post-anesthesia care unit and at 8 hours postoperatively.

Clinical guidelines may lead to better prescribing practices

August 30, 2018

Following clinical guidelines release, decreases were observed in the overall rate of opioid prescribing. 2. Guidelines may be associated with reduced high-dosage opioid prescriptions and the percentage of patients with overlapping benzodiazepine and opioid prescriptions.

PT Better After Hip Surgery Than Opioids in Younger Adults

August 29, 2018

For patients receiving both treatments, the group receiving opioids first had mean hip-related downstream costs that were significantly higher than the group receiving physical therapy first ($18,806 versus $16,955).

FDA Warning Letters Target Illegal Online Sales of Opioids

August 29, 2018

Americans who buy prescription medicines such as opioids from illegal online pharmacies may be putting their health at risk because the drugs may be counterfeit, contaminated, expired, or otherwise unsafe, according to the FDA.

Children's Advil Suspension Recalled Due to Unmatched Dosage Cup

By August 28, 2018

The recalled product has Lot #R51129 (NDC 0573-0207-30) and was shipped to wholesalers, distributors, and retailers from May through June 2018.

Buprenorphine/Naloxone Rx Fills Up With Medicaid Expansion

August 28, 2018

After expansion, there was a significant increase in buprenorphine with naloxone fills per 100,000 county residents in expansion vs non-expansion counties (8.7).

Odds of Marijuana Use Up With Nausea, Vomiting in Pregnancy

August 27, 2018

The prevalence of prenatal marijuana use was 5.3% by self-report or toxicologic test findings; prevalence was greater among females with severe and mild versus no NVP (11.3 and 8.4, respectively, vs 4.5%).

Prescription Drug Monitoring Program May Not Cut Opioid Use

August 27, 2018

In the 6 months before the mandatory PDMP requirement, the mean number of opioid pills prescribed decreased from 30.8 to 24 (22.1%); in the 6 months after the legislation, the decrease was less, from 22.8 to 21.9 pills (3.9%).

Hydrocodone Schedule Change Affected Post-Op Opioid Rx

August 24, 2018

The researchers found that the mean oral morphine equivalents (OMEs) filled in the initial opioid prescription increased by about 35 after the schedule change (β = 35.1; P<.01), which was equivalent to seven hydrocodone tablets (5mg).

Pregabalin may increase the risk of death when coprescribed with opioids

August 21, 2018

Patients coprescribed opioids and pregabalin had significantly increased odds of opioid-related death compared to opioid prescription alone.

Odds of Death Up With Exposure to Pregabalin, Opioids

August 21, 2018

Dose-response association with highest odds of opioid-related death with high-dose prefabbing

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

By August 20, 2018

Last year, the DEA proposed a 20% reduction in the manufacturing of controlled substances for 2018 compared to 2017.

FDA Approves Minimally-Invasive, Non-Drug Therapy for Pain Management

By August 17, 2018

Several clinical trials have demonstrated the SPRINT PNS System to be effective in reducing pain and improving quality of life.

Integration of Opioid, Infectious Disease Treatment Needed

August 15, 2018

"All health care providers have a role in combating the OUD epidemic and its infectious disease consequences. Those who treat infectious complications of OUD are well-suited to screen for OUD and begin treatment with effective US Food and Drug Administration-approved medications," the authors write.