Pain Management

Functional Nasal Surgery Can Improve Headache Symptoms

December 07, 2018

Surgery to remove nasal mucus contact points could reduce symptoms in patients with chronic headache.

Childrens' Pain Reliever Recalled Due to Potentially Higher Potency Level

By December 06, 2018

Ingesting nonsteroidal anti-inflammatory drugs (NSAID) at a higher potency level may cause nausea, vomiting, epigastric pain, diarrhea, tinnitus, headache, and even gastrointestinal bleeding; pediatric patients are also at greater risk of developing NSAID-associated renal injury.

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

By December 06, 2018

An investigational transdermal cannabidiol gel was well-tolerated and consistently effective for adults with focal epilepsy.

Migraine Subtype Linked to Increased Risk of Incident Atrial Fibrillation

December 05, 2018

Migraine with aura is associated with an elevated risk for incident atrial fibrillation, according to a new study.

Rimegepant Zydis ODT Beneficial in Phase 3 Migraine Trial

By December 03, 2018

In Study 303 (N=1375), rimegepant, an oral calcitonin gene-related peptide (CGRP) receptor antagonist, achieved statistical significance in 2 co-primary endpoints: pain freedom and freedom from most bothersome symptom (MBS).

Migraine and Headache Treatments

December 03, 2018

Adult doses for migraine and headache treatments including barbiturates, ergot alkaloids, and NSAIDs.

FDA Clears nVNS Therapy for Prevention of Cluster Headache

By November 29, 2018

The FDA clearance was based on data from 2 studies.

Narcotic Analgesics

November 28, 2018

A comparative chart of narcotic analgesics including formulations, strengths, and dosing intervals.

FDA: "Disturbingly" High Levels of Heavy Metals Found in Kratom Products

By November 28, 2018

The Agency conducted testing on 26 separate kratom products which revealed levels of nickel and lead considered not safe for human consumption.

Experts Offer Tips on Integrating Medical Marijuana Into Geriatric Practice

By November 26, 2018

A study by the National Survey of Drug Use and Health (NSDUH) found that from 2002-2014 the proportion of adults aged 50 to 64 who reported cannabis use in the past year more than tripled from 2.9% to 9.0%. Among adults age 65 or older, there was more than a ten-fold increase (from 0.2% to 2.1%).

FDA Cracks Down on Companies Selling Dietary Supplements Containing Tianeptine

By November 21, 2018

While approved in Europe, Asia and Latin America, tianeptine is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Nonsurgical Treatment Options for Tennis Elbow Compared

November 21, 2018

All treatments increased the odds of adverse events versus placebo

Opioid Misuse Varies With Sexual Orientation

November 19, 2018

Compared with being attracted only to the opposite sex, being attracted mostly to the opposite sex or being equally attracted to both sexes correlated with higher odds for past-year opioid misuse (adjusted odds ratios, 2.15 and 1.78, respectively).

FDA Panel Votes in Favor of Abuse-Deterrent Oxycodone Reformulation

By November 15, 2018

The vote was taken in a joint meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee.

FDA Issues Safety Alert Regarding Intrathecal Delivery of Pain Meds

By November 14, 2018

Reports of pump failure, dosing errors, as well as other possible safety issues have prompted the Agency to issue the alert to make prescribers aware of the dangers associated with using medications not approved for intrathecal use.

Lasmiditan NDA Submitted for Acute Treatment of Migraine

By November 14, 2018

The NDA submission included data from two Phase 3 trials, SAMURAI and SPARTAN.

FDA Grants Non-Opioid Analgesic VVZ-149 Fast Track Status

By November 09, 2018

The Company states that in vivo tests have shown that the compound's pain suppressing efficacy is comparable to morphine.

Quantity of Opioids Prescribed Postop Linked to Consumption

November 08, 2018

A total of 2392 patients who underwent one of 12 surgical procedures were included in the analysis.

Expiration Dates on Naloxone Products May Be Grossly Exaggerated

November 08, 2018

Researchers found that the naloxone nasal spray Narcan was chemically stable for 10 months after its labeled expiration date and that the naloxone injection Evzio was chemically stable for at least 1 year after its listed expiration date.

Pediatric Anesthesia Does Not Affect Development Outcomes

November 06, 2018

Researchers examined the correlation between surgical procedures that require general anesthesia before primary school entry and child development in a retrospective sibling-matched cohort study, including sibling pairs aged 5 to 6 years with the same birth mother.

Opioid Use Appears to Up Risk for Atrial Fibrillation

November 05, 2018

The researchers found that 29.2% of those with AF and 15.4% of those without AF were prescribed opioids.

Dsuvia Approved for Management of Acute Pain in Healthcare Settings

By November 02, 2018

The sublingual formulation of sufentanil offers a new treatment option for patients with nothing by mouth (NPO) status and patients with difficult IV access.

FDA Clears Patient Controller Platform for Stimwave's Neuromodulation Device

By November 02, 2018

The new software enables patients to fine-tune the power level and modify programs that were pre-programmed by their clinician to control pain.

NDA for Non-Opioid Combo Tx for Postoperative Pain Submitted to FDA

By November 02, 2018

The treatment is designed to deliver pain relief directly to the site of tissue injury, thereby potentially reducing the need for systemically administered pain medications.

Case Report Highlights Variable Presentation of Serotonin Syndrome

By October 26, 2018

The patient's past medical history was significant for chronic kidney disease (stage 5) on nightly peritoneal dialysis, type 2 diabetes mellitus, peripheral neuropathy, gastroesophageal reflux disease, hypertension, and chronic pain.

Opioid Use High in Patients With Systemic Lupus Erythematosus

October 26, 2018

Patients with SLE who experienced high pain levels and had a visit to the emergency department the previous year were more likely to use opioids.

Bill to Fight US Opioid Crisis Signed Into Law

October 26, 2018

There is $60 million earmarked for infants who are born drug-dependent and authorization for programs that place drug offenders into treatment instead of in prison.

Expert Opinion: CGRP Receptor Antagonist Use in Pediatric Patients With Migraine

By October 25, 2018

Recommendations on the use of these agents in this patient population were published in a Views and Perspectives paper in the journal Headache.

Red Cross Releases Online Course on How to Respond to an Opioid Overdose

By October 25, 2018

The training has information on how to use several products including a nasal atomizer, Narcan Nasal Spray and Evzio.

Opiate-Free Surgery Feasible for Elective Colectomy

October 23, 2018

The researchers found that 83% of the patients required no narcotic medication postoperatively. Preoperative opioid use significantly predicted postoperative narcotic requirement.