Pain Management

Insurance Company Sets Goal for Reducing Opioid Overdoses by 25%

By June 22, 2018

Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

June 21, 2018

Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

June 20, 2018

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Single-Use Lidocaine 1% Ampules Now Available

By June 19, 2018

The ampules are available immediately.

First Generic Versions of Suboxone Get FDA Approval for Opioid Dependence

By June 15, 2018

The treatment combines buprenorphine, a partial-opioid agonist, with naloxone, an opioid antagonist.

Fremanezumab Chronic Cluster Headache Study Discontinued

By June 15, 2018

Fremanezumab, an anti-CGRP monoclonal antibody, is currently being reviewed by the Food and Drug Administration (FDA) as a quarterly or monthly injection for the preventive treatment of migraine in adults.

Children Can Drink Clear Fluids Until 1 Hour Before Anesthesia

June 15, 2018

Increased thirst and irritability are reported with prolonged fasting period, as well as detrimental physiological and metabolic effects. No increased risk of pulmonary aspiration was reported with a 1-hour clear fluid policy and studies demonstrated that the stomach was empty.

Illicit Opioid Trade Up With Restrictions on Hydrocodone

June 14, 2018

The effects of the US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products on the trade in opioids through cryptomarkets was analyzed by researchers.

Dexmedetomidine Cuts γ-Aminobutyric Acid Receptor Function

June 13, 2018

The researchers found that dexmedetomidine reduced the etomidate-induced sustained increase in α5 γ-aminobutyric acid type A receptor cell-surface expression (etomidate: 146.4 ± 51.6%; etomidate + dexmedetomidine: 118.4 ± 39.1% of control).

Older Age, ICU, Poor Renal Fcn Up Risk of Opioid OD in Hospital

June 13, 2018

The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.

Antiepileptic Treatment Shows Efficacy in Reducing Migraine Frequency

June 12, 2018

The antiepileptic drug levetiracetam may represent an effective prophylactic treatment option for episodic migraine.

Wearable Device Cleared for Use During Opioid Detoxification

By June 12, 2018

Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

June 07, 2018

Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

FDA Issue Warnings to 9 Online Sellers of Illegal Opioids

June 06, 2018

The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

By June 05, 2018

Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder.

Benefit of Liposomal Bupivacaine for Pain in TKA Questioned

June 04, 2018

The researchers found that liposomal bupivacaine was used in 21.2% of patients. Its use was not associated with a clinically meaningful reduction in inpatient opioid prescription, length of stay, or cost of hospitalization.

Studies ID Impact of US Opioid-Related Mortality, Rx Patterns

June 04, 2018

The researchers found that 168,315,458 patients filled IR formulations and 10,216,570 filled extended-release/long-acting (ER/LA) formulations.

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

By June 01, 2018

NKTR-181 is a long-acting selective full mu-opioid agonist.

Galcanezumab Beneficial for Patients With Episodic Migraine, Says Study

May 31, 2018

A total of 858 adults with at least a 1-year history of migraine, 4 to 14 migraine headache days per month, and a mean of at least 2 migraine attacks per month within the past 3 months received once-monthly treatments for 6 months and were followed up for 5 months after the last injection.

Migraine and Headache Treatments

May 25, 2018

Adult doses for migraine and headache treatments including barbiturates, ergot alkaloids, and NSAIDs.

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

By May 23, 2018

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

May 22, 2018

There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.

IV Tramadol Significantly Reduces Post-Op Pain in Phase 3 Study

By May 21, 2018

In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).

AUA: Many Have Unused Opioids After Urologic Procedures

May 21, 2018

The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).

First-of-its-Kind Migraine Drug Gets FDA Approval

By May 18, 2018

The efficacy of Aimovig was evaluated as a preventive treatment of episodic or chronic migraine in 3 randomized, double-blind, placebo-controlled studies: 2 studies in patients with episodic migraine (4-14 migraine days per month) and 1 study in patients with chronic migraine (≥15 headache days per month with ≥8 migraine days per month).

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

By May 17, 2018

Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Fremanezumab effective in preventing episodic migraine

May 17, 2018

In this randomized controlled trial, Fremanezumab slightly decreased the amount of headache free days in those with episodic migraines compared to placebo.