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In pooled analyses of the 2 studies, consistently greater reduction was seen in MADRS scores from baseline for BUP/SAM 2mg/2mg versus placebo at multiple time points, including EOT and average change from baseline to week three through EOT.

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The main reasons that physicians with waivers indicated no willingness to increase prescribing were lack of belief in agonist treatment (odds ratio, 3.98), lack of time for additional patients (odds ratio, 5.54), and belief that reimbursement rates are insufficient (odds ratio, 2.50).