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Despite current guidelines, many patients with atrial fibrillation (A-fib) and ischemic stroke (IS) are not receiving antithrombotic therapy after hospital discharge or are receiving antiplatelet therapy alone, increasing their risk of major vascular events.

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Dabigatran is associated with higher risks of major bleeding and gastrointestinal bleeding compared with warfarin, but patients taking dabigatran also have a reduced risk of intracranial bleeding compared with those taking warfarin, according to new research.

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Major bleeding events are rare in patients with stable coronary artery disease (CAD); however, concomitant antiplatelet therapy (APT) when oral anticoagulation is required increases bleeding risk – an independent predictor of mortality – and should be reconsidered in select patients.