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Bardoxolone methyl does not reduce the risk of end-stage renal disease (ESRD) or cardiovascular death in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease.

Compromised kidneys significantly reduce survival and life expectancy in patients with systemic lupus erythematosus (SLE).

Being overweight or obese as an adolescent is significantly associated with increased risk for all-cause treated end-stage renal disease (ESRD).

Kidney stones correlate with an increased risk of adverse kidney outcomes, including end-stage renal disease (ESRD), Stage 3b-5 chronic kidney disease, and sustained doubling of serum creatinine, but increases in absolute rates are small.

The lifetime risk of developing end-stage renal disease (ESRD) is higher for men than women, at all ages and estimated glomerular filtration rate (eGFR) strata.