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Individuals with genetic profiles putting them at risk of greater smoking are more likely to progress to heavy smoking and nicotine dependence, particularly if they quickly became daily smokers and heavy smokers as adolescents.

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Subjects who are enrolled in the Atherosclerosis Risk in Communities (ARIC) study and are meeting goals for 6-7 ideal health metrics have a 51% lower risk of incident cancer than those not meeting any goals for ideal health metrics.