Oncology

AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

By May 18, 2018

"We are confident this guideline is fully aligned with the latest science on treatments for patients with non-metastatic and metastatic CRPC," said Michael Cookson, MD, member of the 2018 amendment panel.

Immune Checkpoint Inhibitor Efficacy Varies by Sex

May 17, 2018

The researchers found that, compared with men treated in control groups, the pooled overall survival hazard ratio was 0.72 for male patients treated with immune checkpoint inhibitors.

Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

May 16, 2018

Per 10,000 person-years of observation, the incidence rates of CRC were 20, 9.1, and 7.5 for advanced adenoma, non-advanced adenoma, and no adenoma, respectively.

PPD Skin Test Enhances Bacillus Calmette-Guérin Tx in Bladder CA

May 16, 2018

The researchers found that the mean ± standard deviation 5-year recurrence-free survival rate was 66.6 ± 2.8% and 59.1 ± 4.1% for patients who did and did not undergo the purified protein derivative skin test, respectively (P=.048).

Blood-Filtering Device Gets Breakthrough Designation for Cancer Tx

By May 15, 2018

In preliminary preclinical studies, the device has been shown to enhance anti-cancer immune system response without causing adverse effects

Peripheral Neuropathy Common in Childhood Cancer Survivors

May 15, 2018

Clinical abnormalities consistent with peripheral neuropathy were common and were observed in about half (50.5%) of those treated with neurotoxic chemotherapy

Risk Models Help Select Ever Smokers for Lung CA Screening

May 15, 2018

The researchers found that the models chose US screening populations ranging from 7.6 to 26 million ever-smokers.

Primary Care Providers Have Mixed Views on Genetic Tests

May 14, 2018

They find tests for genetic risk potentially useful, but lack confidence in interpreting results

Teledermatology Could Expedite Care for Suspected Skin Cancer

May 14, 2018

The researchers found that the mean time to clinical resolution was 9 days with teledermoscopy referral, compared with 35 days with usual care alone.

Wine Consumption and Prostate Cancer Risk: Is There a Link?

May 14, 2018

In multivariable analysis, moderate white wine consumption increased the risk of prostate cancer (pooled risk ratio, 1.26; 95% confidence interval, 1.10 to 1.43; P=.001).

HPV Vaccination May Offer Protection Against Cervical Precancer

By May 11, 2018

The authors concluded, "There is high-certainty evidence that HPV vaccines protect against cervical precancer in adolescent girls and young women aged 15 to 26," while also indicated that future studies should have long-term follow-up.

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

By May 11, 2018

At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

Many Oncologists Discuss, Recommend Medical Marijuana

May 11, 2018

The researchers found that only 30% of oncologists felt sufficiently informed to make recommendations regarding medical marijuana.

Treatment for Rare Pediatric Cancer Granted Orphan Drug Designation

By May 10, 2018

CLR 131 is an investigational radioiodinated Phospholipid Drug Conjugate (PDC) drug candidate that delivers cytotoxic radiation directly and selectively to malignant cells.

Multiple Myeloma Treatment Gains Orphan Drug Designation

By May 10, 2018

Galinpepimut-S targets the Wilms Tumor 1 (WT1) protein, present in an array of tumor types.

Lymphoma, Leukemia Survivors Have Increased Health Care Use

May 10, 2018

The researchers found that survivors of lymphoma and CLL contacted their general practitioner and medical specialist more often within the last year vs the control population.

USPSTF: Final Recommendation Statement on Prostate Cancer Screening

By May 09, 2018

The Task Force recommends that for men 55 to 69 years of age, the decision to undergo prostate-specific antigen (PSA)-based screening for prostate cancer should be an individual one.

Chronic Aspirin Exposure Linked to Melanoma Risk in Males

May 09, 2018

After stratification by gender, a significant correlation was seen for aspirin exposure and melanoma diagnosis among males (adjusted relative risk, 1.83; 95% confidence interval, 1.22 to 2.76; P=.004), but not females (adjusted relative risk, 0.53; 95% confidence interval, 0.17 to 1.63; P=.266).

Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence

May 09, 2018

Among the patients with low-grade non-muscle-invasive urothelial cancer who underwent TURBT and drug instillation, 34 of 102 and 59 of 113 in the gemcitabine and saline groups, respectively, had cancer recurrence.

Darzalex + VMP Approved for New Diagnosed Multiple Myeloma

By May 08, 2018

VMP consists of Velcade, a proteasome inhibitor (PI); melphalan, an alkylating agent; and prednisone, a steroid.

Akynzeo for Injection Available for Chemotherapy-Induced Nausea, Vomiting

By May 08, 2018

The intravenous formulation combines fosnetupitant (prodrug of netupitant), a substance P/NK1 receptor antagonist, and palonosetron, a 5-HT3 receptor antagonist.

Long-Term Cardiovascular Risk for Endometrial Cancer Survivors

May 08, 2018

The researchers found that there were increased cardiovascular risks among endometrial cancer survivors for phlebitis, thrombophlebitis, and thromboembolism (hazard ratio, 2.07); pulmonary heart disease (hazard ratio, 1.74); and atrial fibrillation (hazard ratio, 1.5).

Cancer Incidences and Burden Expected to Shift in HIV-Positive

May 08, 2018

The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030, with prostate and lung cancer projected to be the most common cancer types.

Tafinlar + Mekinist Approved for BRAF-Positive Anaplastic Thyroid Cancer

By May 04, 2018

Study data showed 57% of evaluable patients (N=23) had a partial response and 4% achieved a complete response. Among the 14 responders, 64% did not have significant tumor growths for ≥6 months.

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure

May 04, 2018

Women with DES-related clear-cell adenocarcinoma had 27-fold higher mortality at 10 to 34 years

Computer analysis is not better than human clinical evaluation when it comes to measuring breast density

May 03, 2018

Similar associations were observed with clinical BI-RADS and automated BI-RADS with respect to interval and screen-detected cancer.

Undisclosed Lab Result Leads to Lawsuit After Patient's Death

By May 02, 2018

Dr P's expert testified that there was nothing to treat or to tell the patient about.

CAR-T Therapy Kymriah Approved for Relapsed/Refractory Large B-Cell Lymphoma

By May 02, 2018

Kymriah uses the 4-1BB costimulatory domain in its chimeric antigen receptor to enhance cellular expansion and persistence.

Tafinlar + Mekinist Approved for Adjuvant Tx of Melanoma With BRAF V600 Mutation

By May 01, 2018

Approval was based on COMBI-AD, an international, multi-center, randomized, double-blind, placebo-controlled trial in 870 patients with Stage III melanoma with BRAF V600E or V600K mutations, and pathologic involvement of regional lymph node(s).

Checklist Developed for Parents of Children With Cancer

April 30, 2018

"Focusing education on the most important topics before the first hospital discharge and only teaching additional topics if parents have time to understand can help parents remember the important, relevant information," the authors said.