Obesity

Early Antibiotic Use May Be Tied to Higher Childhood Body Weight

November 27, 2018

The researchers identified 362,550 eligible children (52% boys, 27% African-American, 18% Hispanic), of whom 58% received at least 1 antibiotic prescription at <24 months of age.

Many new pediatric asthma cases attributable to obesity

November 26, 2018

Despite increased efforts to prevent and reduce obesity, rates of childhood obesity continue to increase.

Maximum BMI over 24-year weight history linked to increased all-cause mortality

November 20, 2018

Using data from the original and offspring Framingham cohort studies, a 24-year weight history was obtained prior to analysis of mortality.

Does Obesity Impact Virological Response in HCV Patients on DAA Therapy?

By November 14, 2018

The review analyzed 168 patients treated with an oral DAA at a single center from 2015 to 2017.

HHS: Updated Physical Activity Guidelines for Americans Released

By November 12, 2018

This guidance, updated for the first time since 2008, provides evidence-based recommendations for children (ages 3-17) and adults.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

November 01, 2018

The researchers found that 72.4, 11.8, and 3.3% of children were prescribed an antibiotic, an H2RA, and a PPI, respectively. There was an association between antibiotic prescriptions and obesity (hazard ratio, 1.26).

Gastric bypass most effective for weight loss among common bariatric procedures

October 31, 2018

Roux-en-Y gastric bypass was found to be the most effective bariatric procedure reviewed in this study in terms of patient weight loss.

Saxenda Labeling Updated With Cardiovascular Safety Data

By October 23, 2018

The randomized, double-blind, placebo-controlled, parallel-group study (N=9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.

Obesity Negatively Affects Treatment Response to JAK Inhibitors in RA

October 22, 2018

Patients treated with JAK inhibitors for rheumatoid arthritis may be less likely to have low disease activity if they are obese compared with those who are overweight.

Sharp Drop in US Life Expectancy Rankings by 2040

October 19, 2018

Life expectancy in the US has declined in each of the past 2 years, according to the National Center for Health Statistics. That's the first multi-year decrease since 1962 and 1963.

Lorcaserin Reduces Risk of Incident Diabetes in Patients With Prediabetes

By October 05, 2018

In this new analysis, researchers looked at the long-term effects of the drug on diabetes prevention and remission in these patients.

USPSTF Recommends Intensive Behavioral Change for Obesity

September 20, 2018

Task Force finds adequate evidence that multi-part interventions can improve weight status

Lorcaserin Facilitates Weight Loss Without Increasing Risk of Major CV Events

By August 27, 2018

In the CAMELLIA-TIMI 61 study, 12,000 overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors were randomized to receive either lorcaserin 10mg twice daily or placebo.

Low-Energy Diet Induces Different Effects in Men, Women

August 15, 2018

Men had larger reductions in metabolic syndrome Z-score, C-peptide, fat mass, heart rate

AHA: A Diverse Diet May Not Promote a Healthy Weight

August 10, 2018

The authors report that current data do not support greater dietary diversity as an effective strategy to promote healthy eating patterns and healthy body weight.

PCOS and Overweight/Obesity: Drug Therapies for Weight Reduction Compared

By August 06, 2018

Researchers identified 23 randomized-controlled trials that included patients with PCOS and overweight/obesity (N=941) and compared the effectiveness of various pharmacological interventions (i.e., metformin, inositol, liraglutide, orlistat) on weight reduction.

Results From Long-Term Cardiovascular Safety Study of Lorcaserin Announced

By July 19, 2018

Approximately 12,000 patients took part in the CAMELLIA-TIMI 61 trial in which participants were randomized to either lorcaserin HCl 10mg twice daily or placebo.

Adult Obesity Prevalence Varies With Level of Urbanization

June 20, 2018

Age-adjusted prevalence of obesity was increased for men living in medium or small metropolitan statistical areas (MSAs) versus those living in large MSAs (42.4 vs 31.8%); the difference for men living in large MSAs vs non-MSAs was not statistically significant.

Antipsychotic Tx Linked to Adiposity Changes in Youths

June 14, 2018

The researchers found that from baseline to week 12, the dual-energy X-ray absorptiometry percentage total body fat increased by 1.18, 4.12, and 1.66% for risperidone, olanzapine, and aripiprazole, respectively, and was significantly greater for olanzapine than risperidone or aripiprazole.

FDA Approves Updated Labeling for Two Obesity Treatments

By June 04, 2018

Specifically, the new labeling includes updated data on the global rate of occurrence related to these adverse events.

CVD Risk Up Even in Metabolically Healthy Obese Women

May 31, 2018

Compared to women with stable healthy normal-weight, women who maintained metabolically healthy obesity during follow-up were still at elevated cardiovascular risk (hazard ratio, 1.57); this risk was lower than for initially metabolically healthy women who converted to an unhealthy phenotype (hazard ratios, 1.90 and 2.74 for normal-weight and obesity, respectively).

Lesbian, Bi Women More Likely to Develop T2DM at Younger Age

May 09, 2018

Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.

Improved research methods needed to determine effectiveness of anti-obesity public health initiatives

May 02, 2018

Researchers found that amongst nearly 300 studies reporting the impact of policies, programs, or changes in built environment on controlling and preventing obesity, most natural experiments had high risk of bias and poor handling of dropouts and withdrawals.

Severe Obesity Tied to Faster Progression to Disability With RA

May 01, 2018

The researchers found that at baseline, severely obese patients had higher disability scores versus overweight patients in both Forward and VARA.

Review: Need to Strengthen Natural Experiments in Obesity

May 01, 2018

In terms of study design, guidance, documentation, and communication about methods used should be improved. Cross-cutting recommendations are provided for improving the rigor of natural experiments in obesity.

Family-Based Treatment of Teen Eating Disorders Helpful

April 30, 2018

The researchers found that on average, patients and their parents perceived FBT as "quite helpful" and "extremely helpful," respectively.

About 40 Percent of Men Report Experiencing Weight Stigma

April 25, 2018

Weight stigma was associated with increased odds of having a body mass index (BMI) consistent with underweight or obesity compared with normal weight.

Factors ID'd to Predict Fatty Liver in Obese Teens

April 24, 2018

"The combination of ethnicity/race with markers of insulin resistance and genetic factors might help identify obese youth at risk for developing fatty liver," the authors write.

Factors ID'd for Breastfeeding Behavior in Women With BMI &#8805;30

April 06, 2018

Five factors correlated with breastfeeding behaviors: intentions to breastfeed; belief in the nutritional adequacy and sufficiency of breast milk; belief about others' infant feeding preferences; body image; and social knowledge.

Obesity Can Negatively Affect Liver in Children As Young As 8

April 06, 2018

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.