Obesity

USPSTF Recommends Intensive Behavioral Change for Obesity

September 20, 2018

Task Force finds adequate evidence that multi-part interventions can improve weight status

Lorcaserin Facilitates Weight Loss Without Increasing Risk of Major CV Events

By August 27, 2018

In the CAMELLIA-TIMI 61 study, 12,000 overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors were randomized to receive either lorcaserin 10mg twice daily or placebo.

Low-Energy Diet Induces Different Effects in Men, Women

August 15, 2018

Men had larger reductions in metabolic syndrome Z-score, C-peptide, fat mass, heart rate

AHA: A Diverse Diet May Not Promote a Healthy Weight

August 10, 2018

The authors report that current data do not support greater dietary diversity as an effective strategy to promote healthy eating patterns and healthy body weight.

PCOS and Overweight/Obesity: Drug Therapies for Weight Reduction Compared

By August 06, 2018

Researchers identified 23 randomized-controlled trials that included patients with PCOS and overweight/obesity (N=941) and compared the effectiveness of various pharmacological interventions (i.e., metformin, inositol, liraglutide, orlistat) on weight reduction.

Results From Long-Term Cardiovascular Safety Study of Lorcaserin Announced

By July 19, 2018

Approximately 12,000 patients took part in the CAMELLIA-TIMI 61 trial in which participants were randomized to either lorcaserin HCl 10mg twice daily or placebo.

Adult Obesity Prevalence Varies With Level of Urbanization

June 20, 2018

Age-adjusted prevalence of obesity was increased for men living in medium or small metropolitan statistical areas (MSAs) versus those living in large MSAs (42.4 vs 31.8%); the difference for men living in large MSAs vs non-MSAs was not statistically significant.

Antipsychotic Tx Linked to Adiposity Changes in Youths

June 14, 2018

The researchers found that from baseline to week 12, the dual-energy X-ray absorptiometry percentage total body fat increased by 1.18, 4.12, and 1.66% for risperidone, olanzapine, and aripiprazole, respectively, and was significantly greater for olanzapine than risperidone or aripiprazole.

FDA Approves Updated Labeling for Two Obesity Treatments

By June 04, 2018

Specifically, the new labeling includes updated data on the global rate of occurrence related to these adverse events.

CVD Risk Up Even in Metabolically Healthy Obese Women

May 31, 2018

Compared to women with stable healthy normal-weight, women who maintained metabolically healthy obesity during follow-up were still at elevated cardiovascular risk (hazard ratio, 1.57); this risk was lower than for initially metabolically healthy women who converted to an unhealthy phenotype (hazard ratios, 1.90 and 2.74 for normal-weight and obesity, respectively).

Lesbian, Bi Women More Likely to Develop T2DM at Younger Age

May 09, 2018

Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.

Improved research methods needed to determine effectiveness of anti-obesity public health initiatives

May 02, 2018

Researchers found that amongst nearly 300 studies reporting the impact of policies, programs, or changes in built environment on controlling and preventing obesity, most natural experiments had high risk of bias and poor handling of dropouts and withdrawals.

Severe Obesity Tied to Faster Progression to Disability With RA

May 01, 2018

The researchers found that at baseline, severely obese patients had higher disability scores versus overweight patients in both Forward and VARA.

Review: Need to Strengthen Natural Experiments in Obesity

May 01, 2018

In terms of study design, guidance, documentation, and communication about methods used should be improved. Cross-cutting recommendations are provided for improving the rigor of natural experiments in obesity.

Family-Based Treatment of Teen Eating Disorders Helpful

April 30, 2018

The researchers found that on average, patients and their parents perceived FBT as "quite helpful" and "extremely helpful," respectively.

About 40 Percent of Men Report Experiencing Weight Stigma

April 25, 2018

Weight stigma was associated with increased odds of having a body mass index (BMI) consistent with underweight or obesity compared with normal weight.

Factors ID'd to Predict Fatty Liver in Obese Teens

April 24, 2018

"The combination of ethnicity/race with markers of insulin resistance and genetic factors might help identify obese youth at risk for developing fatty liver," the authors write.

Factors ID'd for Breastfeeding Behavior in Women With BMI ≥30

April 06, 2018

Five factors correlated with breastfeeding behaviors: intentions to breastfeed; belief in the nutritional adequacy and sufficiency of breast milk; belief about others' infant feeding preferences; body image; and social knowledge.

Obesity Can Negatively Affect Liver in Children As Young As 8

April 06, 2018

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.

Change in BMI During Puberty Tied to Later Heart Failure Risk

March 30, 2018

Compared with boys who were neither overweight during childhood or puberty, boys developing overweight during puberty had increased risk of heart failure.

Recent Years Have Seen Obesity Prevalence Increasing for Adults

March 28, 2018

Increases in prevalence were seen for women, adults aged 40 to 59 years, and 60 years or older. The age-standardized prevalence of severe obesity increased significantly from 5.7% in 2007 to 2008 to 7.7% in 2015 to 2016

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

March 28, 2018

No residual effect for past users, including early discontinuers of menopause hormone treatment

Cryoablation of Posterior Vagal Trunk Feasible in Obesity

March 23, 2018

Technical success rate 100 percent in 10 subjects; no procedure-related complications, adverse events

Significant Weight Loss Seen With Once-Daily Semaglutide in Obese Adults

By March 19, 2018

Novo Nordisk is planning on initiating a Phase 3 trial of semaglutide that will include 4,500 individuals who are overweight or obese sometime in 2018. Semaglutide is currently not approved for treatment of obesity.

How Does Medical Tx Compare To Bariatric Surgery in Obese Diabetes Patients?

March 14, 2018

The researchers found that the mean hemoglobin A1c concentration decreased from 6.8 to 5.5% in Teen-LABS and increased from 6.4 to 7.8% in TODAY participants during 2 years.

Increased Offspring BMI Tied to Metformin Exposure In Utero

March 01, 2018

The researchers found that at age 4 years there was a non-significant difference in height z-scores between children of women randomized to placebo and those randomized to metformin.

Sex Specific Relationship Between Obesity and Myocardial Infarction Examined

February 28, 2018

During 7 years of follow-up, the researchers identified 5,710 cases of MI among 265,988 women and 213,622 men without a history of cardiovascular disease at baseline. In both sexes, there was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI.

Infant Gut Microbiota May Mediate Intergenerational Transmission of Obesity

February 22, 2018

The researchers found that infants born vaginally to overweight or obese mothers were significantly more likely to become overweight at age 1 year, compared with being born vaginally to a normal-weight mother (adjusted odds ratio, 3.33).

Obese Individuals May Have Greater Metastatic Melanoma Survival Odds

February 21, 2018

The obesity-related survival benefit was seen only for patients receiving targeted therapy (hazard ratios, 0.72 and 0.6 for progression-free and overall survival, respectively) and immunotherapy (hazard ratios, 0.75 and 0.64, respectively), not for patients receiving chemotherapy.

USPSTF: Obese Patients Should Be Referred to Multicomponent Behavioral Interventions

February 21, 2018

Draft recommendation statement concludes that doctors should provide, refer adults to interventions