Does Prenatal Tdap Vaccination Increase Autism Risk in Offspring?

By August 14, 2018

Currently, the Advisory Committee on Immunization Practices (ACIP) recommends pregnant women receive the Tdap vaccination to prevent pertussis infection.

FDA Approves First Mobile App for Use in Preventing Pregnancy

By August 13, 2018

The algorithm was designed to account for sperm survival, variation in cycle length, ovulation day, temperature fluctuations and the length of the follicular and luteal phases of the menstrual cycle.

Self-Administered Contraceptive Vaginal System Approved for Up to 1 Year of Use

By August 13, 2018

The safety and efficacy of Annovera was evaluated in 3 open-label clinical trials involving healthy women (ages 18 to 40).

CDC: Rates of Opioid Use Disorder Seen at Time of Delivery Up

August 13, 2018

Rate of opioid use disorder at time of delivery quadrupled from 1999 to 2014

Cytovene-IV Labeling Updated to Include Additional Fertility Impairment Data

By August 10, 2018

Cytovene-IV is a deoxynucleoside analogue cytomegalovirus (CMV) DNA polymerase inhibitor.

Sufficient Preconception Vitamin D Tied to Lower Miscarriage Risk

August 10, 2018

Among women who achieved pregnancy, sufficient preconception 25-hydroxyvitamin D was associated with reduced risk of pregnancy loss (preconception RR per 25nmol/L, 0.88; 95% confidence interval, 0.77 to 0.99); but this was not found at 8 weeks of gestation (RR, 0.98; 95 percent confidence interval, 0.95 to 1.01).

FDA: Improper Use of Rupture of Membranes Tests Linked to Fetal Deaths

By August 09, 2018

ROM tests are used to aid in diagnosing ruptured membranes in pregnant women through analysis of vaginal secretions.

Inducing Labor at Term Appears to Reduce Cesarean Risk

August 09, 2018

Elective induction at 39 weeks also linked to lower risk of maternal high blood pressure disorders

Thyroid Dysfunction Linked to Gestational Diabetes

August 07, 2018

The researchers found that both fT3 and fT3-to-fT4 ratio were positively correlated with GDM (adjusted odds ratios, 4.25 and 3.89 comparing the highest versus the lowest fT3 quartile at first and second trimester, respectively).

PCOS and Overweight/Obesity: Drug Therapies for Weight Reduction Compared

By August 06, 2018

Researchers identified 23 randomized-controlled trials that included patients with PCOS and overweight/obesity (N=941) and compared the effectiveness of various pharmacological interventions (i.e., metformin, inositol, liraglutide, orlistat) on weight reduction.

Drugs Contraindicated in Pregnancy

August 03, 2018

Contraindicated pregnancy medications

Alcohol Exposure Via Breastmilk May Affect Infant Development

August 02, 2018

The researchers found that in children who had been breastfed, there was a correlation for increased or riskier wave 1 maternal alcohol consumption with reductions in Matrix Reasoning scores at age 6 to 7.

FDA: Energy-Based Devices Should Not Be Used for Vaginal "Rejuvenation"

By July 31, 2018

The Agency has become aware of some manufacturers marketing these devices for vaginal "rejuvenation" or vaginal cosmetic procedures.

ACOG, Others Come Out Against Proposed Rule on Title-X

July 26, 2018

Organizations representing over 700,000 women and adolescent health care providers, including the ACOG, the AAP, and the American College of Physicians, are opposing all efforts to limit medically accurate health care information available to patients and exclude qualified providers from participating in the Title-X program.

First IVF Baby Louise Brown Turns 40

July 26, 2018

Her mother was among about 280 women who were part of an IVF experiment. Only 5 of them became pregnant, and Brown was the only birth.

FDA Clears Smartphone-Enabled Urinalysis Kit for Home Use

By July 25, 2018

The Dip.io kit works in tandem with existing smartphone cameras and a dedicated app.

Coal and Oil Power Plant Pollution May Lower Fertility Rates

July 25, 2018

The researchers estimated that after power plant retirement, annual fertility rates per 1000 women aged 15 to 44 years increased by 8 births within 5km and 2 births within 5 to 10km of power plants, yielding incident rate ratios of 1.2 (95% confidence interval, 1.1 to 1.4) and 1.1 (95% confidence interval, 1.0 to 1.2), respectively.

Eleven Infant Deaths Halt Trial of Sildenafil in Pregnant Women

July 25, 2018

Previous research in rats suggested that sildenafil might boost blood flow in the placenta and promote a baby's growth, The Guardian reported.

Orilissa Approved for Moderate to Severe Pain Associated With Endometriosis

By July 24, 2018

The approval was based on data from 2 multinational double-blind, placebo-controlled Phase 3 trials involving 1686 premenopausal women with moderate to severe pain associated with endometriosis.

Unfavorable Prepregnancy Lipid Levels Linked to Low Parity

July 23, 2018

The researchers observed an association for higher prepregnancy triglyceride (TG) and TG to high-density lipoprotein cholesterol (TG:HDL-c) ratio levels with increased risk of one lifetime pregnancy, compared with having 2 or more children.

Essure System for Permanent Birth Control to Be Discontinued

By July 20, 2018

The Company maintains that the safety and efficacy of the device remains consistent and that the reason for this discontinuation is strictly business-related.

Quadrivalent HPV Vaccine Not Tied to Spontaneous Abortion

July 17, 2018

No evidence of increased risk of spontaneous abortion when inadvertently given before or during pregnancy

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

By July 13, 2018

Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Placebo Effect of Various Female Sexual Dysfunction Drug Txs Assessed

By July 12, 2018

For this study, the authors aimed to quantify this effect by conducting a systematic review of various databases to identify studies that included a placebo arm and used Female Sexual Function Index as a clinical outcome.

Reproductive Dysfunction Risk in Women Taking Long-Term Pain Meds

July 10, 2018

Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Prenatal Folic Acid Fortification May Affect Cortical Development

July 09, 2018

A retrospective, observational clinical cohort study was conducted among 292 youths (Massachusetts General Hospital [MGH] cohort) aged 8 to 18 years born between January 1993 and December 2001.

For Postpartum Hemorrhage, Carbetocin Similar to Oxytocin

July 05, 2018

Heat-stable carbetocin non-inferior for preventing blood loss of 500 ml, use of other uterotonic agents

Data Needed on New Type 2 Diabetes Therapies in Pregnancy

July 02, 2018

Scarce data on new glucose-lowering agents, with high risk for bias toward negative outcomes

Preservative-Free, Generic Version of Makena Now Available

By June 28, 2018

Hydroxyprogesterone Caproate is used to lower the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth.

Labeling for Nausea Drugs Used During Pregnancy Updated With New Warning

By June 27, 2018

The Warnings and Precautions section for both products has been updated to inform clinicians that there have been reports of false positive urine screening tests for methadone, opiates, and phencyclidine phosphate (PCP) with doxylamine succinate/pyridoxine hydrochloride use.