Nonnarcotic Analgesics

CDC: About 1 in 5 US Adults Have Chronic Pain

September 14, 2018

The prevalences of both chronic pain and high-impact chronic pain were higher among women; older adults; adults who were previously, but not currently, employed; adults living in poverty; those with public health insurance; and rural residents.

First-in-Class Non-Opioid for Post-Surgical Pain Gets Breakthrough Tx Designation

By September 12, 2018

CA-008 is given as a single local injection and works by selectively desensitizing pain-conducting nerve fibers without causing numbness or weakness

Cardiovascular Health Risks Identified With Diclofenac Use

By September 07, 2018

To investigate the cardiovascular risks associated with diclofenac, researchers conducted a series of cohort studies mimicking the design criteria of a clinical trial.

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

By August 31, 2018

The new plan will break out the current guidance into 4 separate guidances.

Preemptive Analgesia May Cut Post-Op Pain in Anorectal Surgery

August 31, 2018

The researchers found that patients in the active group had significantly less pain in the post-anesthesia care unit and at 8 hours postoperatively.

Children's Advil Suspension Recalled Due to Unmatched Dosage Cup

By August 28, 2018

The recalled product has Lot #R51129 (NDC 0573-0207-30) and was shipped to wholesalers, distributors, and retailers from May through June 2018.

FDA Approves Minimally-Invasive, Non-Drug Therapy for Pain Management

By August 17, 2018

Several clinical trials have demonstrated the SPRINT PNS System to be effective in reducing pain and improving quality of life.

Diclofenac May Slow Cognitive Decline in Alzheimer Disease

July 25, 2018

Study results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

By July 18, 2018

The 16-week, double-blind, placebo-controlled, multicenter, parallel-group study included 698 patients who were randomized to 3 treatment groups: 2 doses of tanezumab 2.5mg; 1 dose of tanezumab 2.5mg followed by tanezumab 5mg, or 2 doses of placebo; each injection was administered once every 8 weeks.

IV Acetaminophen Minimally Helpful for Colectomy Pain

July 09, 2018

More than 1 dose of intravenous acetaminophen on postoperative day 1 was associated with lower opioid utilization (−12.4%) vs non-use, while an even stronger reduction was seen in those receiving more than one oral acetaminophen dose (−22.6%).

Are Anticonvulsants Effective for Low Back Pain?

By July 03, 2018

For this review, the authors searched 5 large databases for studies that compared the use of anticonvulsants (i.e., topiramate, gabapentin, pregabalin) in adult patients with LBP, sciatica, or neurogenic claudication with placebo.

Aspirin Use Doesn't Cut Cancer Incidence in Older T2DM Patients

June 25, 2018

Aspirin did not affect cancer incidence in men, women, or those aged ≥65 years in subgroup analyses but there was a decrease in cancer incidence associated with aspirin use among those aged <65 years.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Ticagrelor &#43; Aspirin Beneficial After Elective CABG

April 25, 2018

The researchers found that the rates of saphenous vein graft patency were 88.7, 82.8, and 76.5%, respectively, with ticagrelor + aspirin, ticagrelor alone, and aspirin alone at one year post-CABG.

Celecoxib Lowers Opioid Use Post Head &amp; Neck Cancer Surgery

April 23, 2018

The researchers observed a correlation for celecoxib treatment in the postoperative setting with decreased mean use of opioids in oral, intravenous (IV), and total amount of morphine equivalents per day.

GI Safety Compared for NSAIDs in Patients With Arthritis

By April 19, 2018

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Polypharmacy More Likely for Cancer Survivors

April 18, 2018

"Cancer survivors were prescribed a higher number of unique medications, including drugs with abuse potential, thereby increasing their risk of adverse drug events, financial toxicity, poor adherence, and drug-drug interactions," the authors write.

Neuroscience Education, Motor Control Training Ease Spinal Pain

April 17, 2018

The researchers found that reduced pain, higher pressure pain thresholds at primary test site at 3 months, and reduced central sensitization inventory scores at 6 and 12 months were experienced by participants in the experimental group.

Noninvasive Brain Stimulation May Help Prevent Migraines

April 04, 2018

"This open label study suggests that sTMS may be an effective, well-tolerated treatment option for migraine prevention," the authors write.

NSAID Use May Increase Atrial Fibrillation Risk for Some

By March 21, 2018

NSAID use was associated with an 18% increased risk of Afib in this population.

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Comparative Safety of NSAIDs Among Clopidogrel Users Investigated

By March 15, 2018

Using Medicaid claims from 5 states (1999-2010) and Medicare claims for dual-enrollees, study authors analyzed the first concomitant use of clopidogrel and 1 of 10 selected NSAIDs (ibuprofen, celecoxib, naproxen, rofecoxib, meloxicam, diclofenac, indomethacin, valdecoxib, nabumetone, etodolac) after a 1-year baseline period.

Virtual Reality Distraction May Help Reduce Procedural Pain

March 15, 2018

The researchers found that VR was effective for reducing procedural pain, even in patients subjected to extremely painful procedures, such as those with burn injuries undergoing wound care and physical therapy.

Peripheral Neuropathy Management: A Guide for Primary Care Clinicians

By March 14, 2018

Peripheral neuropathy is tied to significant morbidity and decrease in quality of life, therefore it is imperative to efficiently diagnosis.

Acupuncture for Treating Pain: Should It Be Recommended?

March 12, 2018

The reasons for and against recommending acupuncture for treating pain are discussed in a head-to-head article.

Excess Acetaminophen Intake, Overdosing Seen During Cold/Flu Season

By March 08, 2018

"This is the first multi-year, year-round study that includes detailed data on how consumers used acetaminophen medications," said Dr. Shiffman.

Year-Long Study Assesses Opioid vs. Non-Opioid Tx for Back, Osteoarthritis Pain

March 07, 2018

The researchers observed no significant difference between the groups in pain-related function over 12 months (overall P=0.58); the mean 12-month Brief Pain Inventory (BPI) interference was 3.4 and 3.3 for the opioid and non-opioid groups, respectively.

Certain Factors May Increase the Likelihood of Gabapentin Overuse

By March 01, 2018

The likelihood of gabapentin overuse alone is low but increased significantly with concomitant opioid use.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

By February 28, 2018

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.