Nonnarcotic Analgesics

IV Acetaminophen Minimally Helpful for Colectomy Pain

July 09, 2018

More than 1 dose of intravenous acetaminophen on postoperative day 1 was associated with lower opioid utilization (−12.4%) vs non-use, while an even stronger reduction was seen in those receiving more than one oral acetaminophen dose (−22.6%).

Are Anticonvulsants Effective for Low Back Pain?

By July 03, 2018

For this review, the authors searched 5 large databases for studies that compared the use of anticonvulsants (i.e., topiramate, gabapentin, pregabalin) in adult patients with LBP, sciatica, or neurogenic claudication with placebo.

Aspirin Use Doesn't Cut Cancer Incidence in Older T2DM Patients

June 25, 2018

Aspirin did not affect cancer incidence in men, women, or those aged ≥65 years in subgroup analyses but there was a decrease in cancer incidence associated with aspirin use among those aged <65 years.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Ticagrelor &#43; Aspirin Beneficial After Elective CABG

April 25, 2018

The researchers found that the rates of saphenous vein graft patency were 88.7, 82.8, and 76.5%, respectively, with ticagrelor + aspirin, ticagrelor alone, and aspirin alone at one year post-CABG.

Celecoxib Lowers Opioid Use Post Head &amp; Neck Cancer Surgery

April 23, 2018

The researchers observed a correlation for celecoxib treatment in the postoperative setting with decreased mean use of opioids in oral, intravenous (IV), and total amount of morphine equivalents per day.

GI Safety Compared for NSAIDs in Patients With Arthritis

By April 19, 2018

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Polypharmacy More Likely for Cancer Survivors

April 18, 2018

"Cancer survivors were prescribed a higher number of unique medications, including drugs with abuse potential, thereby increasing their risk of adverse drug events, financial toxicity, poor adherence, and drug-drug interactions," the authors write.

Neuroscience Education, Motor Control Training Ease Spinal Pain

April 17, 2018

The researchers found that reduced pain, higher pressure pain thresholds at primary test site at 3 months, and reduced central sensitization inventory scores at 6 and 12 months were experienced by participants in the experimental group.

Noninvasive Brain Stimulation May Help Prevent Migraines

April 04, 2018

"This open label study suggests that sTMS may be an effective, well-tolerated treatment option for migraine prevention," the authors write.

NSAID Use May Increase Atrial Fibrillation Risk for Some

By March 21, 2018

NSAID use was associated with an 18% increased risk of Afib in this population.

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Comparative Safety of NSAIDs Among Clopidogrel Users Investigated

By March 15, 2018

Using Medicaid claims from 5 states (1999-2010) and Medicare claims for dual-enrollees, study authors analyzed the first concomitant use of clopidogrel and 1 of 10 selected NSAIDs (ibuprofen, celecoxib, naproxen, rofecoxib, meloxicam, diclofenac, indomethacin, valdecoxib, nabumetone, etodolac) after a 1-year baseline period.

Virtual Reality Distraction May Help Reduce Procedural Pain

March 15, 2018

The researchers found that VR was effective for reducing procedural pain, even in patients subjected to extremely painful procedures, such as those with burn injuries undergoing wound care and physical therapy.

Peripheral Neuropathy Management: A Guide for Primary Care Clinicians

By March 14, 2018

Peripheral neuropathy is tied to significant morbidity and decrease in quality of life, therefore it is imperative to efficiently diagnosis.

Acupuncture for Treating Pain: Should It Be Recommended?

March 12, 2018

The reasons for and against recommending acupuncture for treating pain are discussed in a head-to-head article.

Excess Acetaminophen Intake, Overdosing Seen During Cold/Flu Season

By March 08, 2018

"This is the first multi-year, year-round study that includes detailed data on how consumers used acetaminophen medications," said Dr. Shiffman.

Year-Long Study Assesses Opioid vs. Non-Opioid Tx for Back, Osteoarthritis Pain

March 07, 2018

The researchers observed no significant difference between the groups in pain-related function over 12 months (overall P=0.58); the mean 12-month Brief Pain Inventory (BPI) interference was 3.4 and 3.3 for the opioid and non-opioid groups, respectively.

Certain Factors May Increase the Likelihood of Gabapentin Overuse

By March 01, 2018

The likelihood of gabapentin overuse alone is low but increased significantly with concomitant opioid use.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

By February 28, 2018

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Cardiovascular Risk Compared Among COX-2 Selective, Nonselective NSAIDs

By February 22, 2018

Results showed the crude hazard ratio (HR) of major cardiovascular events was 1.99 (95% CI, 1.28-3.09) for COX-2 vs. nonselective NSAIDs.

Does Hydroxychloroquine Improve Symptoms of Hand Osteoarthritis?

By February 20, 2018

Findings do not support the current practice of off-label use of hydroxychloroquine for treating symptomatic hand osteoarthritis.

Patients With Trigeminal Neuralgia Receive a Variety of Treatments

By February 15, 2018

A total of 3,685 trigeminal neuralgia patients were included for analysis.

Post-Op Analgesia Strategies Compared Following Scoliosis Surgery

February 15, 2018

In base-case analysis, use of opioids alone was both most costly and least effective, while opioids plus intravenous acetaminophen was intermediate in both cost and effectiveness, and opioids plus intravenous acetaminophen and ketorolac was the least expensive and most effective strategy.

Ibuprofen Use During First Trimester May Harm Fetal Ovaries

February 02, 2018

Pregnant women who take ibuprofen in the first trimester may reduce daughters' egg reserve

Prevalence of Excessive NSAID Use Examined Among Ibuprofen Users

By January 26, 2018

Overall - including all NSAIDs - 15% of participants exceeded the maximum daily dose on at least 1 dairy day.

Impact of Marijuana Use on Cardiovascular Health Investigated

January 23, 2018

The researchers identified 13 studies examining associations between marijuana use and cardiovascular risk factors and 11 studies examining associations with clinical outcomes.

Trends in Gabapentinoid Use Explored in U.S. Adult Population

January 02, 2018

More than three-fold increase in percentage of adults using gabapentin and/or pregabalin

Perioperative Gabapentin Use May Promote Post-Op Opioid Cessation

December 14, 2017

But perioperative gabapentin is linked to increase in rate of opioid cessation after surgery