Young, Middle-Aged Adults Critically Ill in 2014 Influenza A(H1N1)pdm09 Infection
the MPR take:
Compared to seasonal influenza epidemics, the 2009 influenza A(H1N1)pdm09 virus pandemic was characterized by many young or middle-aged adults among the critically ill patients. In addition, risk factors such as morbid obesity, pregnancy, and early postpartum period were noted. In 2014, over 60% of laboratory-confirmed influenza-associated hospitalizations and deaths attributed to H1N1 were in adults younger than 65 years. This could be due to the low rates of influenza vaccine coverage in these age groups and lack of past exposure to antigenically related viruses. Identification of potential critically ill patients, antiviral treatment strategies and end points, immunomodulators and other adjunctive therapies, and ARDS rescue strategies are all recommended by the authors as topics for further review.
The 2009 pandemic caused by influenza A(H1N1)pdm09 virus resulted in more than 18,500 reported US deaths and global estimates that were 15-fold higher. In contrast to seasonal influenza epidemics, during which elderly persons have the highest risk for hospitalization and death, many critically ...
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