Calcium, Vit. D Supplementation Linked to Increased Risk of Serrated Polyps
(HealthDay News) — Calcium supplements, taken with or without vitamin D, may increase the risk of sessile serrated adenomas or polyps (SSA/Ps), according to a study published online March 1 in Gut.
Seth D. Crockett, M.D., M.P.H., from the University of North Carolina at Chapel Hill, and colleagues randomized patients with one or more adenomas to receive either 1,200 mg/day of elemental calcium, 1,000 IU/day of vitamin D3, both supplements, or neither supplement. The effects of supplementation on the incidence of serrated polyps was evaluated.
The researchers found that serrated polyps (SPs) were diagnosed in 565 of 2,058 participants (27.5 percent) during the treatment phase and in 329 of 1,108 (29.7 percent) during the observational phase. During follow-up, a total of 211 SSA/Ps were detected. There was no effect of either calcium or vitamin D on incidence of SSA/Ps during the treatment phase. However, during the observational phase, there was an elevated risk of SSA/Ps associated with calcium alone and calcium plus vitamin D treatment (adjusted risk ratios, 2.65 and 3.81, respectively).
"In a large multicenter chemoprevention study, we found evidence that calcium and vitamin D supplementation increased the risk of SSA/Ps," the authors write. "These possible risks must be weighed against the benefits of calcium and vitamin D supplementation."
Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.