Intervention Demonstrates Significant T2D Remission in Primary Care
HealthDay News — Intensive weight management implemented in primary care practices can result in remission of type 2 diabetes for almost half of patients, according to a study published online December 5 in The Lancet.
Michael E.J. Lean, MD, from the University of Glasgow in the United Kingdom, and colleagues randomized 49 primary care practices in a 1:1 ratio to provide a weight management program (intervention) or best-practice care by guidelines (control). A total of 306 individuals aged 20 to 65 years who had been diagnosed with type 2 diabetes in the past 6 years, had a body mass index of 27 to 45kg/m², and were not receiving insulin were recruited.
The researchers recorded weight loss of 15kg or more in 24 participants in the intervention group and none in the control group at 12 months (P<0.0001). Diabetes remission was achieved by 46 and 4% of participants in the intervention and control groups, respectively (odds ratio, 19.7). In the whole study population, remission varied with weight loss; remission was achieved by none of those who gained weight, 7, 34, 57, and 86% of participants who maintained 0 to 5kg weight loss, had 5 to 10kg weight loss, had 10 to 15kg weight loss, and who lost 15kg or more, respectively.
"Remission of type 2 diabetes is a practical target for primary care," the authors write.
Several disclosed financial ties to the pharmaceutical and weight loss industries.