Oral Semaglutide vs Empagliflozin for HbA1c: Efficacy Compared

Those treated with oral semaglutide 14mg saw an improvement in HbA1c of 1.4% at week 26 and 1.3% at week 52.
Those treated with oral semaglutide 14mg saw an improvement in HbA1c of 1.4% at week 26 and 1.3% at week 52.

Treatment with oral semaglutide 14mg led to a statistically significant improvement in hemoglobin A1c (HbA1c) levels and weight loss in adults with type 2 diabetes (T2D) not well controlled with metformin, according to a press release from Novo Nordisk.

In the 52-week open-label PIONEER 2 trial, researchers compared oral semaglutide 14mg with empagliflozin 25mg in 816 participants with T2D. 

Participants treated with oral semaglutide 14mg saw an improvement in HbA1c of 1.4% at 26 weeks and 1.3% at 52 weeks, compared with 0.9% and 0.8% with empagliflozin 25mg at 26 and 52 weeks, respectively. The American Diabetes Association treatment target of HbA1c <7% was achieved by 72% of the participants taking oral semaglutide compared with 47% of the participants taking empagliflozin at 52 weeks. 

Related Articles

Oral semaglutide was also associated with a weight loss of 4.2kg at 26 weeks and 4.7kg at 52 weeks compared with a weight loss of 3.8kg with empagliflozin 25 mg at both 26 and 52 weeks.

The most common adverse event in the semaglutide group was mild to moderate nausea, which was experienced by 20% of participants. Overall, 11% of patients in the semaglutide group discontinued treatment due to adverse events compared with 4% in the empagliflozin group. 

“We are very excited about these results, which demonstrate that people treated with 14mg oral semaglutide for one year achieved statistically significant reductions in blood glucose and body weight compared to people treated with 25mg empagliflozin,” said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk.

Reference

Oral semaglutide shows superior improvement in HbA1c vs empagliflozin in the PIONEER 2 trial [press release]. Novo Nordisk; Bagsværd, Denmark: May 29, 2019. Accessed May 31, 2018.