ASCO: mFOLFIRINOX Improves Survival in Pancreatic Cancer

And, pre-op chemoradiotherapy linked to longer overall survival than immediate surgery.
And, pre-op chemoradiotherapy linked to longer overall survival than immediate surgery.

HealthDay News — The oxaliplatin, leucovorin, irinotecan, and 5-fluorouracil (mFOLFIRINOX) regimen is associated with longer median disease-free and overall survival in pancreatic ductal adenocarcinoma; and, receiving chemotherapy before surgery is associated with better disease-free survival, according to 2 studies presented at the annual meeting of the American Society of Clinical Oncology, held from June 1 to 5 in Chicago.

Thierry Conroy, MD, from the Institut de Cancérologie de Lorraine in Vandœuvre-lès-Nancy, France, and colleagues randomized patients with histologically proven pancreatic ductal adenocarcinomas, 21 to 84 days after resection, to six cycles of gemcitabine (arm A; 246 patients) or 12 cycles of mFOLFIRINOX (arm B; 247 patients). The researchers found that the median disease-free survival was 12.8 and 21.6 months in arms A and B, respectively, with a median follow-up of 30.5 months (hazard ratio, 0.59). The median overall survival was 34.8 and 54.4 months in arms A and B, respectively (hazard ratio, 0.66).  

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Geertjan van Tienhoven, MD, PhD, from the Academic Medical Center in Amsterdam, and colleagues randomized patients with (borderline) resectable pancreatic cancer to immediate surgery (arm A; 127 patients) and preoperative chemoradiotherapy (arm B; 119 patients). The researchers found that overall survival was significantly better with preoperative chemoradiotherapy (median, 13.5 vs 17.1 months; hazard ratio, 0.71; P=.047). Disease-free survival was also significantly better in arm B (median, 7.9 vs 11.2 months; hazard ratio, 0.67; P=.010).

"This is the first randomized clinical trial to show that preoperative treatment improves outcomes for people with early stages of pancreatic cancer who can have surgery," van Tienhoven said in a statement.

Press Release - Conroy
Press Release - van Tienhoven
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