New Interaction Between Soybeans, Valproic Acid Discovered
the MPR take:
Food-drug interactions may have a big impact on patients prescribed drugs with narrow therapeutic indexes. Soy products have been shown to interfere with medications like, levothyroxine replacement, warfarin, and tamoxifen but no research has examined soy and valproic acid (VPA) until now. This study on mice found that soy pretreatment for five days greatly changed the plasma pharmacokinetics of VPA and its metabolite VPA glucuronide (VPAG) via the induction of liver UDP-glucuronosyltransferase (UGT). A decrease in valproic acid bioavailability was also noted.
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