Multivitamin/Mineral Supplementation and CVD Outcomes: Is There a Link?

MVM use not linked to decreased CVD mortality, CHD mortality, stroke mortality, or stroke incidence.
MVM use not linked to decreased CVD mortality, CHD mortality, stroke mortality, or stroke incidence.

HealthDay News — Multivitamin/mineral (MVM) supplementation seems not to be associated with cardiovascular disease (CVD) outcomes, according to a review published online July 10 in Circulation: Cardiovascular Quality and Outcomes.

Joonseok Kim, MD, from the University of Alabama at Birmingham, and colleagues conducted a comprehensive literature review to examine the correlation between MVM supplementation and CVD outcomes including coronary heart disease (CHD) and stroke. Data from 18 studies with 2,019,862 participants and 18,363,326 person-years of follow-up were included in the analysis. 

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The researchers found that there was no correlation between MVM supplementation and CVD mortality, CHD mortality, stroke mortality, or stoke incidence (relative risks, 1 [95% confidence interval, 0.97 to 1.04], 1.02 [95% confidence interval, 0.92 to 1.13], 0.95 [95% confidence interval, 0.82 to 1.09], and 0.98 [95% confidence interval, 0.91 to 1.05]). In prespecified subgroups, and after adjustment for diet, smoking, physical activity, and study site, there was no correlation between MVM supplements and CVD or CHD mortality. MVM use was associated with reduced risk of CHD incidence (relative risk, 0.88; 95% confidence interval, 0.79 to 0.97); in pooled subgroup analysis of randomized controlled trials, this correlation did not remain significant (relative risk, 0.97; 95% confidence interval, 0.8 to 1.19).

"Our meta-analysis of clinical trials and prospective cohort studies demonstrates that MVM supplementation does not improve cardiovascular outcomes in the general population," the authors write.

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