Unfavorable Prepregnancy Lipid Levels Linked to Low Parity

Higher prepregnancy TG and TG:HDL-c ratio linked to increased risk of one lifetime pregnancy.
Higher prepregnancy TG and TG:HDL-c ratio linked to increased risk of one lifetime pregnancy.

HealthDay News — The risk of having no or only 1 child is elevated for women with an unfavorable prepregnancy lipid profile, according to a study published in the June issue of BMJ Open.

Aleksandra Pirnat, from the University of Bergen in Norway, and colleagues conducted a prospective, population-based cohort study using data for 2645 women giving birth to their first child during 1994 to 2003 (488 one-child mothers and 2157 women with 2 or more births) and 1677 nulliparous women. 

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The researchers observed an association for higher prepregnancy triglyceride (TG) and TG to high-density lipoprotein cholesterol (TG:HDL-c) ratio levels with increased risk of 1 lifetime pregnancy, compared with having 2 or more children. The risk of one lifetime pregnancy was increased for women in the lowest versus the highest quintile of HDL-c levels (odds ratio, 1.7; 95% confidence interval, 1.2 to 2.4) and for women with the highest versus the lowest low-density lipoprotein (LDL) cholesterol, TG, and TG:HDL-c ratio quintiles (odds ratios, 1.2 [95% confidence interval, 0.8 to 1.7]; 2.2 [95% confidence interval, 1.5 to 3.2]; and 2.2 [95% confidence interval, 1.5 to 3.2], respectively). Women with a body mass index ≥25 kg/m² and the highest LDL and total cholesterol levels had similar effects in risk of lifetime nulliparity.

"These findings substantiate an association between prepregnant serum lipid levels and number of children," the authors write.

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