Overall Survival Data Added to Labeling for Multiple Myeloma Drug Kyprolis
The Phase 3 ENDEAVOR (RandomizEd, OpeN Label, Phase 3 Study of Carfilzomib Plus DExamethAsone Vs Bortezomib Plus DexamethasOne in Patients With Relapsed Multiple Myeloma) trial included 929 patients treated with Kyprolis + low-dose dexamethasone versus Velcade + low-dose dexamethasone in relapsed or refractory patients who previously received at least 1 (but not more than 3) prior therapeutic regimens. The primary endpoint was progression-free survival.
According to the new data, Kyprolis + dexamethasone lowered the risk of death by 21% and increased OS by 7.6 months compared with Velcade + dexamethasone in patients with relapsed or refractory multiple myeloma (median OS 47.6 months vs 40.0 months; hazard ratio [HR] 0.79; P=0.01). The full OS data have been published in The Lancet Oncology.
Kyprolis, a proteasome inhibitor, is approved for use:
- In combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received 1 to 3 lines of therapy.
- As a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received 1 or more lines of therapy.
Kyprolis is available as a 30mg or 60mg strength lyophilized powder in single-dose vials for intravenous injection after reconstitution.
For more information call (800) 772-6436 or visit Kyprolis.com.