For Chronic Angina Patients, Depression May Negatively Impact Clinical Outcomes
(HealthDay News) — Development of depression is common in patients with newly diagnosed chronic stable angina, according to a study published online Oct. 4 in Circulation: Cardiovascular Quality and Outcomes.
Natalie Szpakowski, M.D., from Sunnybrook Health Sciences Center in Toronto, and colleagues evaluated occurrence and predictors of depression development in a group of 22,917 patients with a new diagnosis of chronic stable angina based on obstructive coronary artery disease found on angiogram. They also evaluated the impact of depression on clinical outcomes.
The researchers found that the occurrence of depression after diagnosis of chronic stable angina was 18.8 percent (mean follow-up, 1,084 days). Remote history of depression, female sex, and more angina symptoms were predictors of depression. There was a higher risk of death (hazard ratio, 1.83) and admission for myocardial infarction (hazard ratio, 1.36) in patients who developed depression than in nondepressed patients.
"Depression is common in patients with chronic stable angina and is associated with increased morbidity and mortality," the authors write.