Dual-Hormone System May Lower Time in Hypoglycemia in T1DM

Lowest mean time in hypoglycemia seen with dual-hormone closed-loop system during exercise period.
Lowest mean time in hypoglycemia seen with dual-hormone closed-loop system during exercise period.

HealthDay News — For physically active adults with type 1 diabetes, the addition of glucagon delivery to a closed-loop system using wearable sensors with automated exercise detection is associated with reduced hypoglycemia, according to a study published online May 11 in Diabetes Care.

Jessica R. Castle, MD, from the Oregon Health & Science University in Portland, and colleagues enrolled 20 participants with type 1 diabetes. Participants underwent dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over four days in a randomized order. Three moderate-intensity aerobic exercise sessions were included in each arm. 

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The researchers found that the lowest mean time in hypoglycemia was seen with dual-hormone during the exercise period (3.4% vs 8.3 [P=.009], 7.6 [P<.001], and 4.3% [P=.49] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire 4-day study, time in hypoglycemia was also lowest with dual-hormone (1.3% vs 2.8 [P<.001), 2.0 [P=.04], and 3.1% [P=.007] for single-hormone, predictive low glucose suspend, and current care, respectively). During the entire study, time in range was the highest with single-hormone (74.3%, vs 72.0% with dual-hormone; P=.44).

"The addition of glucagon delivery to a closed-loop system with automated exercise detection reduces hypoglycemia in physically active adults with type 1 diabetes," the authors write.

Two authors disclosed financial ties to Pacific Diabetes Technologies.

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