Is Domperidone Effective for Increasing Breast Milk Volume?

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Mothers of preterm infants with insufficient milk supply had 88.3 mL/day increase in milk volume
Mothers of preterm infants with insufficient milk supply had 88.3 mL/day increase in milk volume

HealthDay News — Domperidone is well tolerated and effective in producing a moderate short-term increase in expressed breast milk volume among mothers of preterm infants, according to a review published online February 22 in BJOG: An International Journal of Obstetrics and Gynaecology.

Luke E. Grzeskowiak, PhD, from the University of Adelaide in Australia, and colleagues conducted a literature review to identify randomized controlled trials that compared domperidone with placebo in mothers of preterm infants (<37 weeks' gestation) experiencing insufficient milk supply. 

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The researchers identified 5 trials consisting of 194 women. Pooled analysis showed a moderate increase in breast milk volume of 88.3 mL/day with the use of domperidone versus placebo. Maternal adverse events were similar between the groups (odds ratio, 1.05; 95% confidence interval, 0.65 to 1.71), with no reported cases of prolonged QTc syndrome or sudden cardiac death. 

"Domperidone is well tolerated and results in a moderate short-term increase in expressed breast milk volume among mothers of preterm infants previously identified as having insufficient breast milk supply," the authors write.

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