Does Ovarian Preservation Impact Cervical CA Prognosis?
HealthDay News — For women with early-stage cervical adenocarcinoma, ovarian preservation does not impact survival, according to a study published in the October issue of the American Journal of Obstetrics & Gynecology.
Jing Chen, MD, from Huazhong University of Science and Technology in Wuhan, China, and colleagues examined the impact of ovarian preservation on prognosis in a retrospective study involving 194 women with cervical adenocarcinoma. Follow-up was completed for 159 women. The authors compared the impact of ovarian preservation on prognosis for 33 women with ovarian preservation and 126 who underwent bilateral salpingo-oophorectomy.
The researchers found that survival did not differ significantly for women with bilateral salpingo-oophorectomy and ovarian preservation (P=0.423 for disease-free survival and P=0.330 for overall survival). Significant independent prognostic factors related to poor disease-free survival included tumor size (>4cm), deep cervical stromal invasion, and lymph node metastasis; lymph node metastasis correlated with overall survival. There was a significant difference in the relationship between ovarian metastasis and deep cervical stromal invasion, lymph node metastasis, and parametrial invasion among the 153 women with cervical adenocarcinoma who underwent bilateral salpingo-oophorectomy. In meta-analysis of the literature, clinical stage IIB versus I to IIA, deep stromal invasion, lymph node metastasis, corpus uteri invasion, and parametrial invasion correlated with ovarian metastasis.
"Ovarian preservation has no effect on prognosis in women with early-stage cervical adenocarcinoma," the authors write.