Do Renal Artery Stents Lead to Better Outcome vs. Medication-Only?
According to results from a National Institutes of Health-funded study, a commonly used stenting procedure in the renal artery appears to offer no significant improvement when added to medication-based therapy.
The CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) Study evaluated 947 patients whose plaque build-up in the renal artery narrowed the blood vessel by >60%.
Patients had renal artery stenosis and either a systolic blood pressure of >150mmHg while taking 2 or more drugs or Stage 3 (moderate) chronic kidney disease. They were randomized to receive medication therapy only or medication therapy plus a stent.
Researchers examined the impact of both treatment arms on various cardiovascular and renal outcomes, including death, heart attack, hospitalization for CHF, progressive renal insufficiency, or renal replacement therapy.
The study showed 35.1% of patients who received medication and stents experienced one of the negative endpoints compared to 35.8% of patients who received medication alone.
Results of the study can be found in the New England Journal of Medicine.
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