CCHD Newborn Screening May Detect Other Diseases

But the screening may not detect many new cases of critical congenital heart disease
But the screening may not detect many new cases of critical congenital heart disease

HealthDay News — Critical congenital heart disease (CCHD) newborn screening detects a low percentage of new cases of CCHD, but it can detect other important diseases, according to a study published online April 24 in Pediatrics.

Christina L. Diller, MD, from Emory University in Atlanta, and colleagues retrospectively reviewed screening results from 77,148 term newborns without a known CCHD diagnosis at a tertiary birth hospital. The infants were screened using the American Academy of Pediatrics CCHD newborn screening algorithm. In addition, the authors modeled the results of a modified screening algorithm that used a single repeat pulse oximetry test instead of 2. 

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The researchers found that using the current AAP algorithm, 99.96% of infants passed screening. Of the infants who failed, 18 had an initial saturation of <90% and 16 did not attain a passing pulse oximetry level after 3 tests. Evaluation showed one true-positive (total anomalous pulmonary venous return), 33 false-positives – of which 31.3% had significant non-CCHD disease – and 6 false-negatives, yielding an overall specificity of 99.96%, a sensitivity of 14.3%, and a false-positive rate of 0.043%. The modified algorithm also had a sensitivity of 14.3%, but the false-positive rate increased to 0.054%.

"Although CCHD screening in a tertiary care birth hospital may not detect many new cases of CCHD, it can detect other important diseases in newborns," the authors write.

One author disclosed financial ties to Novartis.

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