Congenital Hydrocephalus: Birth Order, Antidepressant Exposure Impact Risk
the MPR take:
Being a first-born child and having first trimester exposure to maternal antidepressant use can increase the risk of isolated congenital hydrocephalus (CHC), says researchers. Dr. Tina Noergaard Munch and colleagues at the Statens Serum Institute in Copenhagen, Denmark, examined 1,193 records of CHC patients from the National Patient Discharge Register between 1978–2008. First-born children had a greater risk of isolated CHC compared to later-borns and first trimester exposure to maternal use of antidepressants had a significantly increased risk. Other risk factors included male gender, multiples, and maternal diabetes.
Objectives: To investigate the associations between isolated congenital hydrocephalus (CHC) and maternal characteristics, maternal medical diseases, and medicine intake during pregnancy as well as birth characteristics of the child in a retrospective, register-based, nationwide cohort study. ...
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