Adjuvant Cannabidiol Examined for Seizure Reduction in Pediatric-Onset Epilepsy

More effective than placebo for reducing seizure frequency, achieving seizure freedom
More effective than placebo for reducing seizure frequency, achieving seizure freedom

HealthDay News — For pediatric-onset treatment-resistant epilepsy, cannabinoids are effective as an adjunctive treatment for reducing seizure frequency by 50% or more, according to a review published online March 6 in the Journal of Neurology, Neurosurgery & Psychiatry.

Emily Stockings, PhD, from the National Drug and Alcohol Research Centre in Sydney, and colleagues reviewed the evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Data were included from six randomized controlled trials and 30 observational studies. The outcomes of interest were 50 percent or more seizure reduction, complete seizure freedom, and improved quality of life.

The researchers found that, compared with placebo, cannabidiol (CBD) 20 mg/kg/day was more effective for reducing seizure frequency by 50% or more (relative risk, 1.74). For one person using CBD to experience a 50% or greater seizure reduction, the number needed to treat was 8. CBD was also more effective than placebo for achieving complete seizure freedom and improving quality of life (relative risks, 6.17 and 1.73, respectively). However, CBD was associated with increased risks of adverse events and serious adverse events (relative risks, 1.24 and 2.55). Overall, pooled across 17 observational studies, 48.5% of patients reported 50% or greater reductions in seizures; 8.5% were seizure-free in 14 observational studies. 

Related Articles

"Pharmaceutical-grade CBD as adjuvant treatment in pediatric-onset drug-resistant epilepsy may reduce seizure frequency," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text