Low-Dose Aspirin May Reduce Ovarian Cancer Risk

Inverse association for low-dose but not standard-dose aspirin with ovarian cancer risk.
Inverse association for low-dose but not standard-dose aspirin with ovarian cancer risk.

HealthDay News — Low-dose aspirin use is associated with a reduced risk for ovarian cancer, according to a study published online October 4 in JAMA Oncology.

Mollie E. Barnard, ScD, from the Harvard T.H. Chan School of Public Health in Boston, and colleagues examined nonsteroidal anti-inflammatory drug (NSAID) use and ovarian cancer diagnosis using data from two prospective cohorts: 93,664 women in the Nurses' Health Study (NHS) and 111,834 in the NHS II. 

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The researchers identified 1054 cases of incident epithelial ovarian cancer among the 205,498 women in both cohorts. When current use vs. non-use of any aspirin was evaluated, significant associations between aspirin and cancer risk were not observed, regardless of aspirin dose (hazard ratio, 0.99; 95% confidence interval, 0.83 to 1.19). On separate analysis of low-dose and standard-dose aspirin, an inverse association was identified for low-dose aspirin (hazard ratio, 0.77; 95% confidence interval, 0.61 to 0.96) but not for standard-dose aspirin (hazard ratio, 1.17; 95% confidence interval, 0.92 to 1.49). Compared with non-use, current use of non-aspirin NSAIDs correlated with ovarian cancer risk (hazard ratio, 1.19; 95% confidence interval, 1.00 to 1.41); there were significant positive trends for duration of use and cumulative average tablets per week (P=.02 and 0.03 for trend, respectively).

"These results support a lower risk of ovarian cancer among low-dose aspirin users, although the association between other nonsteroidal anti-inflammatory drugs and ovarian cancer may be more complex," the authors write.

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