Neurologic Disorders

ADHD Incidence Increases Significantly Following Childhood TBI

March 20, 2018

The researchers found that 25.7% of the 187 children met the definition of SADHD. Compared with the OI group, severe TBI correlated with SADHD (hazard ratio [HR], 3.62; 95% confidence interval [CI], 1.59 to 8.26).

Hizentra Approved for Chronic Inflammatory Demyelinating Polyneuropathy

By March 16, 2018

The PATH study demonstrated that the percentage of patients experiencing CIDP relapse or withdrawal for any other reason during SCIg treatment was significantly lower with Hizentra

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Treatment for Fragile X Syndrome Gets Fast Track Status

By March 15, 2018

A Phase 2 trial of OV101 in males with Fragile X syndrome aged 13 to 22 is planned for later in 2018. OV101 has previously been granted Orphan Drug status for Fragile X and Fast Track status for Angelman syndrome.

Peripheral Neuropathy Management: A Guide for Primary Care Clinicians

By March 14, 2018

Peripheral neuropathy is tied to significant morbidity and decrease in quality of life, therefore it is imperative to efficiently diagnosis.

FDA to Review Xeomin for the Management of Excessive Drooling

By March 14, 2018

The sBLA is based on a Phase 3, randomized, double-blind, placebo-controlled, multicenter 184 subject trial.

Excessive Daytime Sleepiness Linked to β-Amyloid Accumulation in Elderly

March 13, 2018

The researchers found that baseline EDS, defined as an Epworth Sleepiness Scale score of at least 10, was significantly correlated with increased regional Aβ accumulation in the anterior cingulate, posterior cingulate-precuneus, and parietal regions.

Higher Sun Exposure Tied to Lower Risk of Multiple Sclerosis

March 08, 2018

Findings based on sun exposure at 5 to 15 years of age and at 5 to 15 years before MS onset

Adjuvant Cannabidiol Examined for Seizure Reduction in Pediatric-Onset Epilepsy

March 07, 2018

Researchers found for one person using CBD to experience a 50% or greater seizure reduction, the number needed to treat was 8.

Multiple Sclerosis Drug Being Pulled from the Market

By March 02, 2018

Because of its safety profile, the use of Zinbryta is generally reserved for patients who have had an inadequate response to 2 or more MS drugs.

Possible Association Between Diesel Exposure and Greater ALS Risk Identified

February 28, 2018

The researchers found that for men with any occupational exposure to DE, the odds ratio for ALS increased with increasing lag periods and was significant using a 10-year lag (adjusted odds ratio, 1.20). For men with >50% probability of DE exposure, the results were stronger.

Can Tears Be Used to Diagnose Parkinson's Disease?

February 23, 2018

The researchers observed a significant decrease in total alpha-synuclein in tears from PD patients relative to healthy controls (423.12 ± 52.6 versus 703.61 ± 136.4 pg/mg tear protein). PD patients also had significantly increased oligomeric alpha-synuclein relative to controls (1.45 ± 0.31 versus 0.27 ± 0.07ng/ng tear protein).

Prenatal Valproate Exposure May Impact Offspring School Performance

February 21, 2018

The researchers found that children exposed to valproate scored worse on the sixth-grade Danish tests (adjusted difference, −0.27 standard deviation [SD]) and sixth-grade mathematics tests (adjusted difference, − 0.33 SD) .

FDA Accepts NDA for Orally Inhaled Levodopa Therapy Inbrija

By February 21, 2018

Inbrija (previously known as CVT-301) is a self-administered, orally inhaled levodopa; it is designed to deliver a precise dose of a dry powder formulation of L-dopa to the lung.

Osmolex ER OK'd for Parkinson's Disease, Drug-Induced Extrapyramidal Reactions

By February 20, 2018

The approval of Osmolex ER was based on bioavailability studies comparing Osmolex ER to immediate-release amantadine.

First Blood Test to Assess Concussion in Adults Gets FDA Approval

By February 15, 2018

Banyan BTI (Brain Trauma Indicator) is an in vitro diagnostic blood test to aid in the evaluation of patients with suspected TBI.

Influenza vaccine not associated with increased risk of epilepsy in children

February 15, 2018

No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.

Study Evaluating Verubecestat in Prodromal Alzheimer's Disease Stopped

By February 14, 2018

APECS is a randomized, placebo-controlled, parallel-group, double-blind Phase 3 clinical trial evaluating the efficacy and safety of verubecestat in people with prodromal AD.

BACE1 Inhibition May Hold Key to Preventing Alzheimer's

February 14, 2018

"Our results demonstrate that sustained and increasing BACE1 inhibition in adults can reverse amyloid deposition in an AD mouse model, and this observation will help to provide guidance for the proper use of BACE1 inhibitors in human patients," the authors write.

New Strength of Glatopa Available for Relapsing MS

By February 13, 2018

Sandoz GlatopaCare will offer a $0 co-pay support program to qualified patients.

Cognitive Enhancement Therapy May Benefit Adults With Autism

February 13, 2018

Participants treated with CET were significantly more likely to gain competitive employment

Fetal Risk After Pregnancy Exposure to Natalizumab Examined

February 08, 2018

And, natalizumab washout period is only predictor of relapse occurrence during pregnancy

Circadian Dysfunction May Serve as Early Alzheimer's Biomarker

January 31, 2018

"The presence of circadian rhythm abnormalities in the preclinical phase of AD suggests that circadian dysfunction could contribute to early disease pathogenesis or serve as a biomarker of preclinical disease," the authors write.

Apomorphine Film Effectively Converts OFF to ON State in PD Patients

By January 30, 2018

The difference in score change for movement disorder from baseline to 30 minutes post-dose between the apomorphine and placebo group was 7.6 (P=0.0002).

Neurodevelopmental Differences Examined in HIV+, HIV-Exposed Children

January 26, 2018

The researchers found that HIV+ and HEU children had lower cognitive and motor scores than their HUU peers within the meta-analysis.

Diet Adherence Substantially Lowers Cognitive Decline in Stroke Survivors

January 26, 2018

The correlation remained unchanged after further adjustment for sex, education, apolipoprotein E4, late-life cognitive activity, caloric intake, physical activity, and smoking (β = 0.08; P=0.03).

Cannabidiol Effective for Treatment-Resistant Lennox-Gastaut Syndrome

January 25, 2018

"Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated," the authors write.

Zonisamide Efficacy Assessed in Dementia With Lewy Bodies

January 25, 2018

The researchers found that the zonisamide 50mg group had significantly greater improvement in Unified Parkinson's Disease Rating Scale part 3 total score at week 12 versus placebo.

Significant Memory, Attention Benefits Associated With Curcumin Supplement

By January 23, 2018

Significant changes in mean FDDNP were found at 18 months in the amygdala and hypothalamus regions of the brain, which control several memory and emotional functions.