Neurologic Disorders

Antiepileptic Drug Indications

September 15, 2018

Comparative chart of antiepileptic drugs (AEDs) and their seizure/epilepsy indications.

Fingolimod Cuts Multiple Sclerosis Relapses in Pediatric Patients

September 13, 2018

The annualized rate of new or newly enlarged lesions on T2-weighted magnetic resonance imaging was 4.39 with fingolimod and 9.27 with interferon beta-1a.

Propofol May Decrease Delay in Neurocognitive Recovery

September 12, 2018

Cognitive function was assessed with a battery of neuropsychological tests before and 1 week after surgery (379 patients completed one-week neuropsychological testing).

Early language exposure predictive of language skills and IQ in school children

September 10, 2018

Language-based interactions between children 18 to 24 months of age and adults predicted intelligence quotient (IQ), verbal comprehension, and expressive and receptive language skills at 9 to 13 years old.

CDC: New Guideline for Pediatric Mild TBI Diagnosis, Management

September 10, 2018

Gradually increasing academic pursuits requires careful planning among the medical, school, and family units to enable prompt return and avoidance of prolonging school absence.

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

By September 06, 2018

The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Despite guidelines, use of CT for head trauma in children remains unchanged

September 05, 2018

The Pediatric Emergency Care Applied Research Network (PECARN) published clinical prediction rules in 2009 to identify children with head trauma for whom computed tomography (CT) neuroimaging can be avoided.

Patient Distressed by Overturn of California End of Life Option Act

September 05, 2018

In the Annals of Internal Medicine, the patient describes his perception that overturning the law shows a lack of compassion for terminally ill patients, asserting that in contrast to the "do no harm" of the Hippocratic oath, doctors are actually doing more harm by keeping terminally ill patients alive.

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

By September 04, 2018

Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).

Ibudilast Appears to Slow Brain Atrophy Progression in MS

August 31, 2018

"Further trials are needed to identify whether the effect on brain atrophy is reproducible and is associated with slowed progression of neurologic disability," the authors write.

Sensor Array May Detect De Novo Parkinson's Disease in Breath

August 27, 2018

The association with other common tests for PD diagnostics, including smell, ultrasound, and nonmotor symptoms, was also examined. Data were included for 29 PD patients after initial diagnosis and 19 control subjects.

Diacomit Approved for the Treatment of Dravet Syndrome

By August 21, 2018

Diacomit was evaluated in 2 multicenter, placebo-controlled, double-blind, randomized studies.

Pregabalin may increase the risk of death when coprescribed with opioids

August 21, 2018

Patients coprescribed opioids and pregabalin had significantly increased odds of opioid-related death compared to opioid prescription alone.

Both Abstinence and High Alcohol Use Linked to Dementia

August 14, 2018

Among those drinking more than 14 units/week, there was a 17% increase in dementia risk with a 7-unit increase in alcohol consumption.

FDA to Review Midazolam Nasal Spray for Seizure Clusters

By August 14, 2018

The NDA includes data from the Phase 3 ARTEMIS 1 trial which evaluated the intranasal spray in 292 patients.

First-in-Class Therapy Approved for Polyneuropathy Caused by hATTR

By August 10, 2018

The mechanism of siRNAs consists of silencing a portion of RNA involved in causing the disease.

Monoclonal Antibody Granted Orphan Drug Status for Frontotemporal Dementia

By August 09, 2018

There are currently no treatments available for frontotemporal dementia.

NIH Releases Large-Scale Dataset of CT Images

August 03, 2018

Unlike most lesion medical image datasets currently available, which can detect only 1 type of lesion, DeepLesion has much diversity and contains critical radiology findings from across the body, including lung nodules, liver tumors, and enlarged lymph nodes.

Alcohol Exposure Via Breastmilk May Affect Infant Development

August 02, 2018

The researchers found that in children who had been breastfed, there was a correlation for increased or riskier wave 1 maternal alcohol consumption with reductions in Matrix Reasoning scores at age 6 to 7.

New Formulation of Status Epilepticus Treatment To Be Reviewed

By July 31, 2018

The product is being reviewed as a treatment for generalized tonic-clonic status epilepticus, for the prevention and treatment of seizures occurring during neurosurgery, as a short-term substitute for oral phenytoin, when oral administration is not possible, and for pediatric use.

FDA Accepts NDA Resubmission for Oral Cladribine in Relapsing MS

By July 30, 2018

The NDA resubmission is in response to the FDA's Complete Response Letter issued in 2011 which requested an improved understanding of the safety risks and overall benefit-risk profile.

Positive Phase 2 Results for Novel Alzheimer Disease Treatment BAN2401

By July 27, 2018

Initial data from Study 201, as announced in December 2017, showed BAN2401 did not meet the primary endpoint.

Certain Statins May Be Associated With Deficits in Cognition, Memory

By July 26, 2018

Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

Diclofenac May Slow Cognitive Decline in Alzheimer Disease

July 25, 2018

Study results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Modifiable Midlife Risk Factors Linked to Late-Onset Epilepsy

July 25, 2018

"Although stroke and dementia were both associated with late-onset epilepsy, vascular and lifestyle risk factors were significant even in the absence of stroke or dementia," the authors write.

Details of Montreal Cognitive Assessment Widely Publicized

July 23, 2018

The researchers identified 405 unique news articles, 190 of which discussed the MoCA in association with President Trump. More than half of these articles (53.7%) included part or all of the MoCA, with 44.2% presenting the questionnaire in its entirety.

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

By July 17, 2018

Researchers searched various databases to identify trials that compared clobazam monotherapy to placebo or another antiepileptic drug in patients with ≥2 unprovoked seizures or a single acute symptomatic seizure requiring short-term continuous treatment.

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

By July 16, 2018

Currently, there are no approved treatments for behavioral symptoms (eg, aggression, agitation) in Alzheimer's disease.

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

By July 16, 2018

Like Sabril, Vigadrone carries a Boxed Warning regarding the risk of permanent vision loss and is only available to healthcare professionals and patients under a special program called the Vigabatrin Risk Evaluation and Mitigation Strategy (REMS) Program

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

By July 09, 2018

The recall affects approximately 470,000 units that include drugs packaged with 3 to 10 tablets per blister card. The blister packs were developed for use in hospitals, however some were sent to retail pharmacies and were likely dispensed for in-home use.