Neurologic Disorders

Patients May Become Immune to Botulinum Toxin Treatments

December 13, 2018

Findings seen among people with dystonia or spasticity treated with botulinum toxin type A

Case Numbers of US Children With Polio-Like Illness Hit Record High

December 12, 2018

The virus EV-D68 is the leading suspect in AFM, but infections with the virus are not new in children and many Americans carry antibodies against it.

Alzheimer's Dementia Treatments

December 11, 2018

A list of medications comparing Alzheimer's Dementia treatments.

Smoking Linked to Cognitive Dysfunction in Fibromyalgia

December 10, 2018

In unadjusted analysis, smoking was identified as a significant risk factor for lower total cognitive functional score and lower MASQ subscale scores in language, verbal memory, visual-spatial memory, and attention.

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

By December 06, 2018

An investigational transdermal cannabidiol gel was well-tolerated and consistently effective for adults with focal epilepsy.

Should Antiepileptic Serum Concentrations Be Monitored More Frequently in Pregnancy?

December 06, 2018

Investigators observed that in pregnant women with epilepsy, the body begins to rapidly metabolize lamotrigine and levetiracetam at week 16 causing a fluctuating pattern of serum drug concentration.

Multiple Sclerosis Guidelines: Disease-Modifying Therapy

December 04, 2018

Recommendations for the use of disease-modifying therapies (DMT) in adults with multiple sclerosis (MS) from the American Academy of Neurology.

Acute Flaccid Myelitis Cases Appear to Have Peaked for 2018

December 04, 2018

The agency noted a pattern of higher numbers of confirmed cases every 2 years. Most cases are reported between August and October, with significant reductions in November. That pattern appears to be repeating this year, the CDC said.

FDA Grants Orphan Drug Designation to Huntington Disease Treatment

By December 03, 2018

In animal studies, the treatment was associated with improvement in both motor and cognitive function.

Case Description Can Reliably Define Acute Flaccid Myelitis

December 03, 2018

Differences between patients with AFM, other diagnoses include asymmetry of weakness

First-in-Class Drug Approved for Lambert-Eaton Myasthenic Syndrome

By November 30, 2018

Firdapse was previously granted Orphan Drug designation and Breakthrough Therapy designation, as well as Priority Review by the FDA.

FDA: MS Drug Linked to Cases of Stroke, Blood Vessel Wall Tears

By November 29, 2018

Sine the approval of Lemtrada in 2014, the Agency has identified 13 cases worldwide of ischemic and hemorrhagic stroke or arterial dissection that occurred shortly after the patient received Lemtrada.

Parkinsonism Treatments

November 29, 2018

Parkinson's drug treatment chart categorized by pharmacological class.

Gene Therapy Forms New Polysynaptic Pathways in Parkinson's

November 29, 2018

The researchers found that participants who received GAD gene therapy developed a unique treatment-dependent polysynaptic brain circuit, reflecting the formation of new polysynaptic functional pathways linking the STN to motor cortical regions.

Risks of Trazodone Similar to Those of Atypical Antipsychotics

November 27, 2018

The researchers found that use of trazodone correlated with similar rates of falls or major osteoporotic fractures compared with use of atypical antipsychotics.

Ocrelizumab May Help Preserve Hand, Arm Function in PPMS

November 26, 2018

Ocrelizumab reduces risk for more severe progression

FDA: Risk of Severe Increase in Disability Following MS Treatment Discontinuation

By November 21, 2018

From September 2010 to February 2018, the FDA has identified 35 cases of severe increased disability accompanied by the presence of new lesions on MRI that occurred 2 to 24 weeks after stopping treatment with fingolimod.

CDC Announces Acute Flaccid Myelitis Task Force

November 21, 2018

Task force is scheduled to submit its first report in early December

Chronic Hepatitis C Infection and Parkinsonism: What's the Link?

By November 19, 2018

In order to determine the association between CHC and parkinsonism, the study authors utilized the National Health Insurance Research Database in Taiwan to identify CHC patients between 2004 and 2012.

AAP Updates Management of Sport-Related Concussion

November 19, 2018

"While more families, physicians and coaches are aware of the health risks of a blow to the head - and more concussions are being reported - we remain concerned about players who try to tough it out without seeking help," Halstead said in a statement.

Rates of neurodevelopmental impairment unchanged in infants born ≤500g in Japan

November 16, 2018

Accurate data on long-term neurodevelopmental outcomes is critical for families and physicians to make informed decisions regarding resuscitation and care of these infants.

Many Patients Do Not Engage Health Care Provider During MS Relapse

November 15, 2018

The annualized relapse distribution was 44.1, 35.5, and 20.2% of patients with less than 1, 1 to 2, and more than 2 relapses, respectively.

Ocrevus Labeling Updated With New Info on Timing of Vaccine Administration

By November 15, 2018

According to a Phase 3b open-label study, Ocrevus may interfere with the effectiveness of non-live vaccines.

Concussion or mild traumatic brain injury linked with increased risk of suicide

November 14, 2018

In this large systematic review and meta-analysis, the risk of suicide was 2 times higher for patients with history of at least 1 concussion or mild TBI.

PET Algorithm Allows Early Prediction of Alzheimer's

November 13, 2018

Researchers collected prospective 18F-FDG PET brain images from the Alzheimer's Disease Neuroimaging Initiative (ADNI; 2109 imaging studies; 1002 patients) and a retrospective independent test set (40 imaging studies; 40 patients).

Fluoxetine Evaluated as Treatment for EV-D68 Acute Flaccid Myelitis

November 13, 2018

In a propensity-adjusted analysis, there was a 0.2 decrease and a 2.5 increase in SLSS from initial examination to latest follow-up for fluoxetine-treated and untreated patients, respectively (P=.015).

Symptom improvement after concussion in pediatrics expected within four weeks

November 12, 2018

In this large, pre-planned secondary analysis of a prospective multi-center cohort study, the majority of symptom improvement was consistently seen in the first week after concussion.

Researchers Identify Coffee Component That May Provide Neuroprotection

By November 08, 2018

The authors found that the compounds known as phenylindanes inhibited the aggregation of the amyloidgenic proteins beta-amyloid and tau.

First-Of-Its-Kind Surgery Restores Boy's Ability to Walk Post-Acute Flaccid Myelitis

November 06, 2018

Nearly 400 people in the United States have been diagnosed since 2014, according to the US Centers for Disease Control and Prevention. So far this year, there have been 72 confirmed cases in 24 states.

Removing Appendix May Lower Risk for Parkinson's Disease

November 05, 2018

The researchers observed a correlation between removal of the appendix decades before PD onset and a lower risk for PD, especially for those living in rural areas.