Narcotic Analgesics

Teens With Mental Health Conditions More Likely to Receive Opioids Long-Term

March 13, 2018

Teens with pre-existing mental health conditions, tx more likely to transition to long-term opioid use

Opioid Rx Patterns Examined for Head and Neck, Lung and Colon Cancer

March 12, 2018

The researchers identified 168 prescriptions associated with HNCA and 571 with LCCA diagnoses. Compared to patients with LCCA, patients with HNCA had significantly increased odds of being prescribed an opioid (odds ratio, 1.68).

CDC: Increases in Opioid-Involved Overdoses in All Five U.S. Regions

March 07, 2018

Per quarter, this rate increased on average by 5.6%. Increases were seen in rates across demographic groups and all 5 U.S. regions; the largest increases were seen in the Southwest, Midwest, and West (about 7 to 11% per quarter).

Year-Long Study Assesses Opioid vs. Non-Opioid Tx for Back, Osteoarthritis Pain

March 07, 2018

The researchers observed no significant difference between the groups in pain-related function over 12 months (overall P=0.58); the mean 12-month Brief Pain Inventory (BPI) interference was 3.4 and 3.3 for the opioid and non-opioid groups, respectively.

Efforts to Reduce Adult Opioid Use Have Not Slowed Pediatric Ingestion

March 06, 2018

The researchers found that there were 3,647 opioid-related hospitalizations in 31 hospitals, of which 42.9% required PICU care. Overall mortality was 1.6%, with annual deaths decreasing from 2.8 to 1.3% over the study period (P<0.001).

Certain Factors May Increase the Likelihood of Gabapentin Overuse

By March 01, 2018

The likelihood of gabapentin overuse alone is low but increased significantly with concomitant opioid use.

Sublocade Now Available for Moderate-to-Severe Opioid Use Disorder

By March 01, 2018

Sublocade is intended for use as part of a complete treatment program that includes counseling and psychosocial support.

FDA to Review NDA for Opioid Analgesic Remoxy ER

By March 01, 2018

Remoxy ER is an abuse-deterrent, extended-release capsule formulation of oxycodone.

Apadaz Approved for the Short-Term Treatment of Acute Pain

By February 23, 2018

Apadaz is an immediate-release combination of benzhydrocodone, a prodrug of hydrocodone, and acetaminophen (APAP).

Study Belies Common Notion That Opioid Patients Fail Outpatient Tapers

February 21, 2018

The researchers found that 38% of the 82 enrolled patients did not complete a 4-month follow-up survey and were considered to have dropped out. There was a negative correlation for depression and a positive correlation for baseline marijuana use with study completion.

Patients With Trigeminal Neuralgia Receive a Variety of Treatments

By February 15, 2018

A total of 3,685 trigeminal neuralgia patients were included for analysis.

Post-Op Analgesia Strategies Compared Following Scoliosis Surgery

February 15, 2018

In base-case analysis, use of opioids alone was both most costly and least effective, while opioids plus intravenous acetaminophen was intermediate in both cost and effectiveness, and opioids plus intravenous acetaminophen and ketorolac was the least expensive and most effective strategy.

Opioid Use May Increase the Risk for Invasive Pneumococcal Disease

February 13, 2018

Strongest associations seen for opioids that were long acting, of high potency, and used at high doses

FDA Analysis Shows Kratom Not "Just a Plant"

By February 07, 2018

Kratom should not be used to treat medical conditions, nor should it be used as an alternative to prescription opioids.

Short, Long Term Opioid Rx Trends Examined in the VA

February 06, 2018

The researchers found that the prevalence of opioid prescribing was 20.8% in 2010, rose to 21.2% in 2012, and declined annually to 16.1% in 2016.

Extended-Release Oxycodone Prodrug Gets Fast-Tracked

By January 30, 2018

A Phase 1 trial of PF614 compared the treatment to Oxycontin in healthy subjects and found that it demonstrated safety and extended-release characteristics of the prodrug delivery.

Cannabidiol Effective for Treatment-Resistant Lennox-Gastaut Syndrome

January 25, 2018

"Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated," the authors write.

FDA: Increasing Number of Companies Selling Unapproved Opioid Cessation Txs

By January 24, 2018

These products have not been demonstrated to be safe or effective and may keep some patients from seeking appropriate, FDA-approved therapies.

Relationship Between Opioid Use and Patient Satisfaction Explored

January 24, 2018

The researchers found that 13.1% of patients with musculoskeletal conditions were opioid users, defined as receiving at least 1 prescription in two 6-month time periods.

DEA: Deregulation Allows NPs, PAs to Prescribe Opioid Use Disorder Treatment

By January 23, 2018

Nurse practitioners (NP) and physician assistants (PA) can now become DATA-Waived qualifying practitioners, allowing them to prescribe and dispense buprenorphine.

Educational Brochure Provides Low-Cost Method of Improving Opioid Disposal

January 22, 2018

The researchers observed a significant increase in the proportion of patients who disposed of their unused opioids among the group receiving the brochure (11 versus 22% P=0.02).

Walmart Offers Unique Opioid Disposal Solution With DisposeRx

By January 17, 2018

Packets contain a crosslinking polymer blend that, when added to the pill bottle with warm water, sequester any form of prescription drugs - including powders, pills, tablets, capsules, liquids or patches - into a non-divertible and biodegradable gel.

Comprehensive Examination of Impact of Tamper-Resistant Oxycodone

January 12, 2018

The researchers observed reduced sales of higher strengths of controlled-release oxycodone and increased sales of other oxycodone formulations.

New Guidelines Published on Opioid Use in Refractory RLS Treatment

By January 09, 2018

Although the research found opioid use to have a favorable risk-benefit ratio, other avenues of treatment should be considered before opioid prescription including addressing iron stores and combination therapy.

Best Practices for Improving Opioid Tapering Discussions Identified

January 02, 2018

Patients should understand individualized reasons for tapering, know their providers will not abandon them

Topical Analgesic Use Improves Pain, Opioid Discontinuation in Study

By December 27, 2017

The analysis evaluated changes in opioid use, other concurrrent medication use, and pain severity and interference in opioid-experienced patients

Arymo ER Tentatively Approved for Expanded Abuse Deterrence Claim

By December 15, 2017

The abuse deterrent data was not included in the original New Drug Application (NDA) label at time of approval due to exclusivity granted to another company.

Urine Drug Monitoring Recommendations for Opioid Use in Chronic Pain

By December 15, 2017

For low-risk patient, testing should be conducted at least yearly, for those at moderate risk, ≥2 times a year, and for those at high risk, ≥3 times a year.

Do Pre-Op Cholesterol Levels Impact Post-Op Pain Outcomes?

December 13, 2017

The researchers observed a weak, but significant, positive correlation between total cholesterol and numeric rating scale scores on post operative days 0 and 1.

Hospital Discharge Prescription Opioid Volume Varies

December 13, 2017

Overall, 35.7% of patients used no opioids in the 24 hours before discharge; 45.6% of these patients were prescribed opioids at hospital discharge.