Narcotic Analgesics

Guidelines Developed for Opioid Use in Vaginal Birth

December 14, 2018

Guidelines have been developed for use of opioids for uncomplicated spontaneous vaginal birth; the draft consensus guidelines were published online.

Evzio Authorized Generic Soon to Be Available

By December 12, 2018

In addition to the new authorized generic, Evzio is now available at $178 per carton (2 auto-injectors per carton) for government agencies, first responders, health departments, and other qualifying groups when they purchase directly from kaléo or authorized distributors.

Prescription Digital Therapeutic Approved for Opioid Use Disorder

By December 11, 2018

reSET-O is intended for use as an adjunct to outpatient treatment that includes transmucosal buprenorphine (medication-assisted-treatment [MAT]) and contingency management for patients aged ≥18 years who are currently under clinician supervision.

Smaller Heads Linked to Opioid-Related Neonatal Abstinence Syndrome

December 10, 2018

Chronic opioid use during pregnancy that causes neonatal abstinence syndrome is associated with smaller neonatal head circumference, according to a new study.

Ultrarestrictive Opioid Rx Protocol Cuts Postoperative Opioid Use

December 10, 2018

An ultrarestrictive opioid prescription protocol (UROPP) can reduce the number of opioids prescribed to patients after gynecologic and abdominal surgery without negative health consequences, according to a new study.

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

By December 06, 2018

An investigational transdermal cannabidiol gel was well-tolerated and consistently effective for adults with focal epilepsy.

FDA: "Disturbingly" High Levels of Heavy Metals Found in Kratom Products

By November 28, 2018

The Agency conducted testing on 26 separate kratom products which revealed levels of nickel and lead considered not safe for human consumption.

Experts Offer Tips on Integrating Medical Marijuana Into Geriatric Practice

By November 26, 2018

A study by the National Survey of Drug Use and Health (NSDUH) found that from 2002-2014 the proportion of adults aged 50 to 64 who reported cannabis use in the past year more than tripled from 2.9% to 9.0%. Among adults age 65 or older, there was more than a ten-fold increase (from 0.2% to 2.1%).

FDA Cracks Down on Companies Selling Dietary Supplements Containing Tianeptine

By November 21, 2018

While approved in Europe, Asia and Latin America, tianeptine is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Opioid Misuse Varies With Sexual Orientation

November 19, 2018

Compared with being attracted only to the opposite sex, being attracted mostly to the opposite sex or being equally attracted to both sexes correlated with higher odds for past-year opioid misuse (adjusted odds ratios, 2.15 and 1.78, respectively).

FDA Panel Votes in Favor of Abuse-Deterrent Oxycodone Reformulation

By November 15, 2018

The vote was taken in a joint meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee.

FDA Issues Safety Alert Regarding Intrathecal Delivery of Pain Meds

By November 14, 2018

Reports of pump failure, dosing errors, as well as other possible safety issues have prompted the Agency to issue the alert to make prescribers aware of the dangers associated with using medications not approved for intrathecal use.

Quantity of Opioids Prescribed Postop Linked to Consumption

November 08, 2018

A total of 2392 patients who underwent one of 12 surgical procedures were included in the analysis.

Opioid Use Appears to Up Risk for Atrial Fibrillation

November 05, 2018

The researchers found that 29.2% of those with AF and 15.4% of those without AF were prescribed opioids.

Dsuvia Approved for Management of Acute Pain in Healthcare Settings

By November 02, 2018

The sublingual formulation of sufentanil offers a new treatment option for patients with nothing by mouth (NPO) status and patients with difficult IV access.

Case Report Highlights Variable Presentation of Serotonin Syndrome

By October 26, 2018

The patient's past medical history was significant for chronic kidney disease (stage 5) on nightly peritoneal dialysis, type 2 diabetes mellitus, peripheral neuropathy, gastroesophageal reflux disease, hypertension, and chronic pain.

Opioid Use High in Patients With Systemic Lupus Erythematosus

October 26, 2018

Patients with SLE who experienced high pain levels and had a visit to the emergency department the previous year were more likely to use opioids.

Bill to Fight US Opioid Crisis Signed Into Law

October 26, 2018

There is $60 million earmarked for infants who are born drug-dependent and authorization for programs that place drug offenders into treatment instead of in prison.

Red Cross Releases Online Course on How to Respond to an Opioid Overdose

By October 25, 2018

The training has information on how to use several products including a nasal atomizer, Narcan Nasal Spray and Evzio.

Opiate-Free Surgery Feasible for Elective Colectomy

October 23, 2018

The researchers found that 83% of the patients required no narcotic medication postoperatively. Preoperative opioid use significantly predicted postoperative narcotic requirement.

High Uptake, Acceptability of Rapid Fentanyl Test Strips

October 22, 2018

There was a correlation between a positive result and older age, homelessness, heroin use, injection drug use, ever witnessing an overdose, and concern about overdose or drugs being laced with fentanyl.

ASA: Patients Assume Post-Op Opioids Are Best for Pain Relief

October 17, 2018

Ninety-four percent of patients who believe they will receive opioids think they will be effective

FDA Panel Votes on Drug/Device Combo to Treat Pain in Medically Supervised Setting

By October 15, 2018

The FDA is not bound by the Committee's recommendation but takes it into consideration when making its decision.

FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine

By October 12, 2018

Oliceridine, a G-protein biased mu-opioid receptor (MOR) ligand, has a unique mechanism of action that allows for more selective pathway activation while avoiding a pathway associated with opioid-related adverse events.

'Urgent' Need for Cannabinoid Trials in Ped Neurologic Disorders

September 21, 2018

Parents use unregulated cannabinoids to manage neurological disorders in children, including seizures, spasticity, and irritability in children with epilepsy, autism-spectrum disorder, and cerebral palsy.

Investigational Tx Shows Promise in Chronic Low Back Pain

By September 19, 2018

An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.

US Senate Passes Opioids Bill

September 19, 2018

Five different committees submitted more than 70 proposals to help craft the bill, called the Opioid Crisis Response Act of 2018.

FDA: Opioid Analgesic REMS Expanded to Include Immediate-Release Products

By September 18, 2018

As part of the REMS program, drug companies with approved opioid analgesics must make training available to prescribers and provide unrestricted grants to accredited continuing education providers for the development of education courses.

CDC: About 1 in 5 US Adults Have Chronic Pain

September 14, 2018

The prevalences of both chronic pain and high-impact chronic pain were higher among women; older adults; adults who were previously, but not currently, employed; adults living in poverty; those with public health insurance; and rural residents.