Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.
Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.
The effects of the US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products on the trade in opioids through cryptomarkets was analyzed by researchers.
The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.
Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.
Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.
The researchers found that 168,315,458 patients filled IR formulations and 10,216,570 filled extended-release/long-acting (ER/LA) formulations.
All opioid misuse patterns examined had a positive association with opioid overdose and death.
A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.
There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.
In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).
The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).
Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.
Researchers examined the extent to which pharmaceutical industry marketing of opioid products to physicians during 2014 correlated with opioid prescribing in 2015.
"An intervention targeting the use of intravenous opioids may be associated with reduced opioid exposure while providing effective pain control to hospitalized adults," the authors write.
All of these studies, however, had methodological shortcomings (ie, inadequate adjustment for time-invariant; time-varying confounding factors; no adjustment for competing laws/policies that may have affected overdoses).
Overall, 9.7% of both marijuana users and non-users experienced VT/VF or cardiac arrest (P=.94); 4.5 and 8.7%, respectively, experienced atrial fibrillation; and 4 and 6%, respectively, died.
For states that currently limit new acute opioid prescription fills to <7 days, Walmart and Sam's Club pharmacies will follow that state law.
Based on data from the National Death Index and electronic health records, suicide risk was 87 per 100,000 among persons with OUD, 6 times that of people in the general US population. Efforts should be made to change opioid prescribing practices and to expand treatment for people with OUD.
Most patients (90.2%) were satisfied with their post-discharge pain control. More than one-quarter (28.2%) reported being prescribed too many opioids, while 8.3% reported not being prescribed enough. Remaining opioids were disposed of by only 7.5% of patients.
Allegations are likely to be that PBMs allowed a greater amount of opioids to be permitted in communities than could be supported based on the legitimate medical needs of the community.
There was a correlation for opioid use with risk for all outcomes in a dose-dependent manner: altered mental status, fall, and fracture.