Narcotic Analgesics

Insurance Company Sets Goal for Reducing Opioid Overdoses by 25%

By June 22, 2018

Through their predictive analytics, Cigna can identify customers most likely to suffer from an overdose and can prompt interventions.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

June 21, 2018

Pain management could be enhanced by research to develop a better understanding of chronic pain and development of new non-addictive pain treatments. To speed movement of non-addictive treatments through the clinical pipeline, a public-private HEAL partnership is planned.

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

June 20, 2018

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

First Generic Versions of Suboxone Get FDA Approval for Opioid Dependence

By June 15, 2018

The treatment combines buprenorphine, a partial-opioid agonist, with naloxone, an opioid antagonist.

Illicit Opioid Trade Up With Restrictions on Hydrocodone

June 14, 2018

The effects of the US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products on the trade in opioids through cryptomarkets was analyzed by researchers.

Older Age, ICU, Poor Renal Fcn Up Risk of Opioid OD in Hospital

June 13, 2018

The researchers found that being age 65 years or older (40.9 versus 29.5%; P=.026), being in an ICU (medical ICU/cardiac ICU: 27.3 versus 3.4%; P<.001; surgical ICU: 18.1 versus 5.7%; P=.031), and having renal impairment (estimated glomerular filtration rate ≤60: 50 vs 28.4%; P=.034) were associated with opioid overdose.

Wearable Device Cleared for Use During Opioid Detoxification

By June 12, 2018

Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

June 07, 2018

Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

FDA Issue Warnings to 9 Online Sellers of Illegal Opioids

June 06, 2018

The U.S. Food and Drug Administration has issued warnings to 9 online companies selling illegal opioid medications on 53 websites, in direct violation of the Federal Food, Drug, and Cosmetic Act.

Studies ID Impact of US Opioid-Related Mortality, Rx Patterns

June 04, 2018

The researchers found that 168,315,458 patients filled IR formulations and 10,216,570 filled extended-release/long-acting (ER/LA) formulations.

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

By June 01, 2018

NKTR-181 is a long-acting selective full mu-opioid agonist.

Physicians should look for misuse patterns that lead to overdose before prescribing opioids

May 29, 2018

All opioid misuse patterns examined had a positive association with opioid overdose and death.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

May 22, 2018

There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.

IV Tramadol Significantly Reduces Post-Op Pain in Phase 3 Study

By May 21, 2018

In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).

AUA: Many Have Unused Opioids After Urologic Procedures

May 21, 2018

The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

By May 17, 2018

Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Opioid-Related Payments Linked to Increase in Opioid Rx

May 15, 2018

Researchers examined the extent to which pharmaceutical industry marketing of opioid products to physicians during 2014 correlated with opioid prescribing in 2015.

Practice Intervention Targeting IV Opioids May Cut Exposure

May 14, 2018

"An intervention targeting the use of intravenous opioids may be associated with reduced opioid exposure while providing effective pain control to hospitalized adults," the authors write.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

By May 09, 2018

All of these studies, however, had methodological shortcomings (ie, inadequate adjustment for time-invariant; time-varying confounding factors; no adjustment for competing laws/policies that may have affected overdoses).

Marijuana Use Not Linked to Risk of Arrhythmias After Acute MI

May 09, 2018

Overall, 9.7% of both marijuana users and non-users experienced VT/VF or cardiac arrest (P=.94); 4.5 and 8.7%, respectively, experienced atrial fibrillation; and 4 and 6%, respectively, died.

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

By May 08, 2018

For states that currently limit new acute opioid prescription fills to <7 days, Walmart and Sam's Club pharmacies will follow that state law.

Opioids Often Overprescribed After Hiatal Hernia Surgery

May 03, 2018

Patients use fewer opioids than are prescribed after open, laparoscopic hiatal hernia repair

People With Opioid Use Disorder Have High Suicide Rate

April 26, 2018

Based on data from the National Death Index and electronic health records, suicide risk was 87 per 100,000 among persons with OUD, 6 times that of people in the general US population. Efforts should be made to change opioid prescribing practices and to expand treatment for people with OUD.

Adults Using Benzodiazepines More Likely to Receive Opioid Rx

April 20, 2018

Increase in new opioid prescriptions for U.S. adults using benzodiazepines stopped in 2010

Study Finds 31% Use No Opioids After Surgery

April 20, 2018

Most patients (90.2%) were satisfied with their post-discharge pain control. More than one-quarter (28.2%) reported being prescribed too many opioids, while 8.3% reported not being prescribed enough. Remaining opioids were disposed of by only 7.5% of patients.

First Opioid Lawsuit Targeting Pharmacy Benefit Managers

April 20, 2018

Allegations are likely to be that PBMs allowed a greater amount of opioids to be permitted in communities than could be supported based on the legitimate medical needs of the community.

Opioids Tied to Adverse Outcomes in Hemodialysis Patients

April 20, 2018

There was a correlation for opioid use with risk for all outcomes in a dose-dependent manner: altered mental status, fall, and fracture.