Narcotic Analgesics

Many Medical Cannabis Users Drive While Under the Influence

January 10, 2019

The prevalence of driving under the influence of cannabis (DUIC) is high among medical cannabis users with chronic pain, according to a study published online January 9 in Drug and Alcohol Dependence.

reSET-O Digital Therapeutic for Opioid Use Disorder Now Available

By January 08, 2019

Sandoz and Pear Therapeutics announced the launch of reSET-O, a new digital therapeutic for patients aged ≥18 years with opioid use disorder (OUD) currently under clinician care.

Sufentanil Sublingual Tablet Well-Tolerated, According to Pooled Safety Data

By January 07, 2019

The pooled analysis (N=804) evaluated clinical studies of sufentanil sublingual tablet (SST) at 30mcg dose equivalents over ≤72 hours for moderate-to-severe acute pain management in both postoperative and emergency room patients.

FDA Approves Two New Strengths of Apadaz for Pain Management

By January 07, 2019

Apadaz was initially approved in February 2018 as 6.12mg/325mg immediate-release tablets for the short-term (no more than 14 days) management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Additional Naloxone Formulation Submitted to FDA for Review

By January 02, 2019

Currently, naloxone is supplied in ampules and vials for IV, IM or SC administration, in a prefilled auto-injector, and as a nasal spray.

More Than Two-Thirds of Drug OD Deaths in 2017 Involved Opioids

December 28, 2018

Significant increases seen in death rates involving synthetic opioids in 15 of 20 states from 2013 to 2017

Opioid Prescribing Patterns Vary for Pediatric Patients

December 28, 2018

Geographic region, race, age, payment method associated with differences in opioid prescribing

Brixadi Gets Tentative FDA Approval for Opioid Use Disorder

By December 27, 2018

Brixadi utilizes FluidCrystal Injection Depot Technology; once in contact with fluids in the tissue, the solution turns into a nanostructured liquid-crystalline gel allowing for slow release of buprenorphine at a steady rate over 1 week or 1 month.

Chronic Opioid Use Among Rheumatoid Arthritis Patients Rising

By December 18, 2018

Using the Corrona RA registry, researchers from Brigham and Women's Hospital, Boston, identified chronic opioid users through surveys completed at study visits.

Buprenorphine-Naloxone Cost-Effective for Opioid Use Disorder

December 18, 2018

Buprenorphine-naloxone is cost-effective compared with extended-release naltrexone for treating opioid use disorder.

Guidelines Developed for Opioid Use in Vaginal Birth

December 14, 2018

Guidelines have been developed for use of opioids for uncomplicated spontaneous vaginal birth; the draft consensus guidelines were published online.

Evzio Authorized Generic Soon to Be Available

By December 12, 2018

In addition to the new authorized generic, Evzio is now available at $178 per carton (2 auto-injectors per carton) for government agencies, first responders, health departments, and other qualifying groups when they purchase directly from kaléo or authorized distributors.

Prescription Digital Therapeutic Approved for Opioid Use Disorder

By December 11, 2018

reSET-O is intended for use as an adjunct to outpatient treatment that includes transmucosal buprenorphine (medication-assisted-treatment [MAT]) and contingency management for patients aged ≥18 years who are currently under clinician supervision.

Smaller Heads Linked to Opioid-Related Neonatal Abstinence Syndrome

December 10, 2018

Chronic opioid use during pregnancy that causes neonatal abstinence syndrome is associated with smaller neonatal head circumference, according to a new study.

Ultrarestrictive Opioid Rx Protocol Cuts Postoperative Opioid Use

December 10, 2018

An ultrarestrictive opioid prescription protocol (UROPP) can reduce the number of opioids prescribed to patients after gynecologic and abdominal surgery without negative health consequences, according to a new study.

Transdermal Cannabidiol Gel Well-Tolerated in Adults With Focal Epilepsy

By December 06, 2018

An investigational transdermal cannabidiol gel was well-tolerated and consistently effective for adults with focal epilepsy.

FDA: "Disturbingly" High Levels of Heavy Metals Found in Kratom Products

By November 28, 2018

The Agency conducted testing on 26 separate kratom products which revealed levels of nickel and lead considered not safe for human consumption.

Experts Offer Tips on Integrating Medical Marijuana Into Geriatric Practice

By November 26, 2018

A study by the National Survey of Drug Use and Health (NSDUH) found that from 2002-2014 the proportion of adults aged 50 to 64 who reported cannabis use in the past year more than tripled from 2.9% to 9.0%. Among adults age 65 or older, there was more than a ten-fold increase (from 0.2% to 2.1%).

FDA Cracks Down on Companies Selling Dietary Supplements Containing Tianeptine

By November 21, 2018

While approved in Europe, Asia and Latin America, tianeptine is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Opioid Misuse Varies With Sexual Orientation

November 19, 2018

Compared with being attracted only to the opposite sex, being attracted mostly to the opposite sex or being equally attracted to both sexes correlated with higher odds for past-year opioid misuse (adjusted odds ratios, 2.15 and 1.78, respectively).

FDA Panel Votes in Favor of Abuse-Deterrent Oxycodone Reformulation

By November 15, 2018

The vote was taken in a joint meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee.

FDA Issues Safety Alert Regarding Intrathecal Delivery of Pain Meds

By November 14, 2018

Reports of pump failure, dosing errors, as well as other possible safety issues have prompted the Agency to issue the alert to make prescribers aware of the dangers associated with using medications not approved for intrathecal use.

Quantity of Opioids Prescribed Postop Linked to Consumption

November 08, 2018

A total of 2392 patients who underwent one of 12 surgical procedures were included in the analysis.

Opioid Use Appears to Up Risk for Atrial Fibrillation

November 05, 2018

The researchers found that 29.2% of those with AF and 15.4% of those without AF were prescribed opioids.

Dsuvia Approved for Management of Acute Pain in Healthcare Settings

By November 02, 2018

The sublingual formulation of sufentanil offers a new treatment option for patients with nothing by mouth (NPO) status and patients with difficult IV access.

Case Report Highlights Variable Presentation of Serotonin Syndrome

By October 26, 2018

The patient's past medical history was significant for chronic kidney disease (stage 5) on nightly peritoneal dialysis, type 2 diabetes mellitus, peripheral neuropathy, gastroesophageal reflux disease, hypertension, and chronic pain.

Opioid Use High in Patients With Systemic Lupus Erythematosus

October 26, 2018

Patients with SLE who experienced high pain levels and had a visit to the emergency department the previous year were more likely to use opioids.

Bill to Fight US Opioid Crisis Signed Into Law

October 26, 2018

There is $60 million earmarked for infants who are born drug-dependent and authorization for programs that place drug offenders into treatment instead of in prison.

Red Cross Releases Online Course on How to Respond to an Opioid Overdose

By October 25, 2018

The training has information on how to use several products including a nasal atomizer, Narcan Nasal Spray and Evzio.

Opiate-Free Surgery Feasible for Elective Colectomy

October 23, 2018

The researchers found that 83% of the patients required no narcotic medication postoperatively. Preoperative opioid use significantly predicted postoperative narcotic requirement.