The 16-week, double-blind, placebo-controlled, multicenter, parallel-group study included 698 patients who were randomized to 3 treatment groups: 2 doses of tanezumab 2.5mg; 1 dose of tanezumab 2.5mg followed by tanezumab 5mg, or 2 doses of placebo; each injection was administered once every 8 weeks.
For this review, the authors searched 5 large databases for studies that compared the use of anticonvulsants (i.e., topiramate, gabapentin, pregabalin) in adult patients with LBP, sciatica, or neurogenic claudication with placebo.
Statin-associated muscle pain can hinder medication adherence which could potentially lead to an increased risk of cardiovascular events.
More emphasis should be placed on self-management, physical and psychological therapies for treating low back pain, rather than pharmacological or surgical treatments.
In patients with anxiety and depression, low-strength evidence of a possible modest benefit was seen in 4 trials conducted more than 40 years ago and in one recent trial compared with sham treatments.
The new and revised standards from The Joint Commission were published in July 2017 to address some of the issues associated with over-prescribing and lack of monitoring.
The device has 14 pre-set therapy modes designed to block acute or chronic pain or to imitate exercise recovery, endurance and muscle strength.
Last April, 450 tons of prescription drugs were collected at almost 5,500 sites operated by the DEA and more than 4,200 state and local law enforcement partners.
Among patients with serum vitamin D levels <20 ng/mL, the prevalence of NP was 5.8 times higher than in patients with vitamin D levels ≥30 ng/mL.
Study authors sought to compare OTC lidocaine 3.6% with menthol 1.25% patches vs. Rx lidocaine 5% as well as to placebo.
Metaxalone, a muscle relaxant (central), is indicated as an adjunct to rest, physical therapy, and other remedies for relief of discomfort associated with acute, painful musculoskeletal conditions.
Results showed a statistically significantly, but not a clinically important, improvement in two of the trials which evaluated radiofrequency denervation for the sacroiliac joints (−0.71 (95% CI, −1.35 to −0.06) and a combination of the facet joints, sacroiliac joints or intervertebral disks (−0.99 (95% CI, −1.73 to −0.25) at 3 months.
In general, the best available evidence pointed to self-management advice, exercise therapy and psychosocial interventions as effective strategies for managing musculoskeletal pain in primary care.
Using data from the Drug Diversion Program of the Researched Abuse, Diversion, and Addiction-Related Surveillance System, the authors were able to calculate the rates of gabapentin diversion (per 100,000 population) for each quarter from 2002-2015
The researchers concluded that stimulant drug use may result in acute stimulant-induced tremor as well as long-term proprioceptive deficits in terms of arm-droop.
New research from The George Institute for Global Health concluded that common nonsteroidal anti-inflammatory drugs (NSAIDs) showed little benefit for spinal pain compared to placebo.
Findings from a systematic review showed low- to moderate-certainty evidence that yoga vs. non-exercise controls resulted in small to moderate improvements in back-related function at Months 3 and 6.
Amputees who experience phantom limb pain may benefit from playing a virtual reality game that simulates the movement of missing limbs, according to a study published online in The Lancet.
Centrexion announced that the Food and Drug Administration (FDA) has granted Fast Track designation to CNTX-4975, a novel therapy intended to treat Morton's neuroma.