Musculoskeletal Disorders

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

By December 05, 2018

To investigate the association between hormone therapy and carpal tunnel syndrome risk, researchers conducted a secondary analysis of the Women's Health Initiative (WHI) hormone therapy trials.

New Psoriatic Arthritis Guidelines Recommend TNFi as First-Line Tx Option

By December 04, 2018

The guideline is jointly authored by the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF).

Higher Cardiovascular Risk Seen With Psoriatic Arthritis

November 30, 2018

Risk seems to be increased especially in patients with a high inflammatory burden, late-onset psoriasis

Filgotinib Safe, Effective for Treatment of Active Ankylosing Spondylitis

November 29, 2018

The TORTUGA trial investigated the efficacy and safety of filgotinib for the treatment of patients with active ankylosing spondylitis.

FDA Fast Track Designation Granted for Investigational Osteoarthritis Treatment

November 28, 2018

The FDA has granted Fast Track designation for GLPG1972/S201086 for the treatment of patients with osteoarthritis.

Risks of Trazodone Similar to Those of Atypical Antipsychotics

November 27, 2018

The researchers found that use of trazodone correlated with similar rates of falls or major osteoporotic fractures compared with use of atypical antipsychotics.

ACTPen, a Single-Dose Prefilled Autoinjector for Actemra, Approved

By November 26, 2018

The FDA approval of the ACTPen was supported by data from 2 studies: an open-label, randomized, 2-period, crossover Phase 1 study (N=188), and an open-label, non-randomized, observational Phase 4 human factors study (N=54).

Bone Erosions More Frequent With Old Age at Onset of Early RA

November 26, 2018

Bone erosions more frequent in those older at early RA onset even if they had clinical remission

Nonsurgical Treatment Options for Tennis Elbow Compared

November 21, 2018

All treatments increased the odds of adverse events versus placebo

Consensus Statement Issued on Management of Foot, Ankle Gout

November 15, 2018

Risk for gouty flares increased with use of thiazide diuretics, excessive alcohol intake

Denosumab Promising for TDT-Induced Osteoporosis Treatment

November 13, 2018

The researchers found that compared with the placebo group, the DNM group had a higher percentage increase of L1 to L4 bone mineral density (5.92 ± 5.25% vs 2.92 ± 5.56%; P=.043) and wrist bone mineral density (−0.26 ± 5.31 vs −3.92 ± 8.71%; P=.035).

TNFi Therapy Affects Joint Ankylosis in Young Patients With Spondyloarthritis

November 12, 2018

TNFi therapy failed to prevent the development of joint ankylosis despite a substantial reduction in inflammation with TNFi therapy.

CDC: About One in Three Adults With Prediabetes Has Arthritis

November 09, 2018

The unadjusted prevalence rates of leisure-time physical inactivity and obesity were 56.5 and 50.1%, respectively, among adults with both arthritis and prediabetes.

CDC: Increases in Yoga, Meditation for Children in 2012-2017

November 09, 2018

The researchers found that from 2012 to 2017, there was an increase in the use of yoga (from 3.1 to 8.4%) and meditation (from 0.6 to 5.4%) during the previous 12 months. In 2017, girls were more likely than boys to have used yoga in the previous 12 months.

Statin-Induced Musculoskeletal AEs and Timing of Concurrent Tx Examined

By November 08, 2018

The data showed MAEs onset was significantly faster with atorvastatin and rosuvastatin compared with simvastatin; a comparison with other statins could not be established due to the small number of cases identified.

Biosimilar Hyrimoz Gains FDA Approval

By November 01, 2018

The FDA's approval was supported by data from analytical, preclinical, and clinical research showing that Hyrimoz matched the reference product's safety, efficacy, and quality.

Clinical Characteristics of Patients With AS Who Discontinue TNFis Explored

By October 30, 2018

To compare the characteristics of patients who discontinued TNFis with those who did not, researchers used the Corrona PsA/SpA Registry to identify patients with AS who were on a TNFi and had ≥2 follow-up visits.

Failure to Meet Optimal Urate Levels Increases Mortality Risk in Gout

October 26, 2018

Patients with gout who did not reach a serum uric acid level below 6 mg/dL had a 2.4-fold increased risk for death.

CVD Risk Reduced in Rheumatoid Arthritis Treated With Methotrexate and bDMARDs

October 26, 2018

A reduction in risk for cardiovascular disease has been reported among patients with rheumatoid arthritis who are receiving concomitant therapy with methotrexate and biologic disease-modifying antirheumatic drugs.

Differences in Ankylosing Spondylitis Outcomes Vary by Gender

October 26, 2018

Clinical improvements during treatment with TNF-α inhibitors was comparable between men and women with ankylosing spondylitis.

Validating Clinical Risk Score of NSAID Toxicity in Osteoarthritis, RA

October 26, 2018

Among the total study population (N=23,953), 5.8% of participants had a predicted 1-year risk of 4%.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

October 25, 2018

Compared with non-users, allopurinol use ≥300mg/day was correlated with a lower risk for developing chronic kidney disease stage ≥3.

Venus Thromboembolism Risk Assessed With Tofacitinib, TNF Inhibitors

October 24, 2018

Although the incidence rate of venous thromboembolism was numerically higher in patients treated with tofacitinib vs TNF inhibitors, the risk was not statistically significant.

Statins May Decrease C-Reactive Protein Levels in Psoriatic Arthritis

October 24, 2018

Statin therapy was associated lower CRP levels in psoriatic arthritis treated with statins, possibly indicating decreased systemic inflammation.

Biologic DMARD Treatment Linked to Weight Gain in Inflammatory Arthritis

October 23, 2018

Small but significant increases in weight (0.02lb) and BMI (0.006 lbl P<.001 for both) were observed over time. Moreover, a negative association between DAS28 and increased weight (-0.56) as well as BMI (-0.08; P<.001 for both) was reported, implying that an increase in weight was linked to lower disease activity.

RAAS Inhibitors and Fracture Risk, Osteoporosis in Postmenopausal Women

October 23, 2018

RAAS inhibitors do not have a deleterious effect on skeletal health in postmenopausal women.

Abatacept May Reduce Diabetes Risk in Rheumatoid Arthritis

October 23, 2018

The researchers concluded their findings indicate that for patients with RA, abatacept reduced the risk for diabetes and "potentially improved insulin sensitivity and glycemic profile."

Ixekizumab Tops Placebo in Axial Spondyloarthritis

October 23, 2018

The researchers found that compared with placebo, the proportion of IXEQ2W and IXEQ4W patients who achieved ASAS 40% response was significantly greater at week 16 (30.6 and 25.4%, respectively, vs 12.5%), with statistically significant differences seen as early as week 1 of treatment.

Walking Each Day May Cut Risk for TKA Over 5 Years

October 23, 2018

Researchers assessed the effect of replacing time not walking with walking at very-light, light, or moderate-to-vigorous intensities on the risk for TKA over 5 years.

Early Initiation of DMARD Tx Tied to Greater Reduction in RA Activity

October 22, 2018

Initiation of DMARD therapy within 6 months of symptom onset was associated with greater reduction in RA disease activity compared with later initiation.