Musculoskeletal Disorders

GI Safety Compared for NSAIDs in Patients With Arthritis

By April 19, 2018

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Less Pain Post TKA With Addition of Peripheral Nerve Blocks

April 19, 2018

The researchers found that intervention patients reported lower numeric rating scale pain scores on ambulation than the control group on postoperative day (POD) one (1.7 versus 5.0; P <.001).

New Drug May Help Infants With Spinal Muscular Atrophy

April 19, 2018

The researchers identified a dose-dependent increase in SMN protein levels in blood; compared with baseline, there was up to a 6.5-fold increase after 4 weeks of treatment at the highest dose of RG7916 (range, 2.0 to 6.5).

Certain RA Treatments Tied to Improvements in Blood Pressure

By April 18, 2018

For this study, researchers used the Veterans Affairs electronic medical record databases to identify unique dispensing of methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, tumor necrosis factor inhibitors, and prednisone in order to assess the effect of these treatments on systolic and diastolic blood pressure (SBP and DBP), as well as incident hypertension among RA patients.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

By April 18, 2018

The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Young Adults With T1DM Show Muscle Metabolic Deficiencies

April 18, 2018

Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.

USPSTF: Exercise Interventions Prevent Falls in Seniors

April 18, 2018

The harms of exercise and multifactorial interventions was found to be no greater than small. Based on these findings, the USPSFT recommends exercise interventions to prevent falls among those at increased fall risk (B recommendation).

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

By April 17, 2018

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

Neuroscience Education, Motor Control Training Ease Spinal Pain

April 17, 2018

The researchers found that reduced pain, higher pressure pain thresholds at primary test site at 3 months, and reduced central sensitization inventory scores at 6 and 12 months were experienced by participants in the experimental group.

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

By April 13, 2018

For older patients, toenail length can provide important insight into a patient's functional status.

Inhibiting mitochondrial responses after intra-articular fracture slows progression of posttraumatic osteoarthritis

April 13, 2018

Intra-articular fractures (IAFs) often lead to posttraumatic osteoarthritis (PTOA) through mechanisms that involve mitochondria.

Elamipretide Granted Orphan Drug Status for Barth Syndrome

By April 09, 2018

The TAZPOWER study is a randomized, double-blind, placebo-controlled Phase 2/3 crossover study evaluating the safety and efficacy of elamipretide (daily subcutaneous injections) in 12 male patients (aged ≥12 years) with genetically-confirmed Barth syndrome.

Top-Line Results Announced for Investigational RA Treatment Upadacitinib

By April 09, 2018

At week 12, results showed 71% in the upadacitinib group had achieved ACR20, compared to 63% and 36% in the adalimumab and placebo groups, respectively.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

April 09, 2018

In models adjusted for sex, education, and disease burden, both polypharmacy and excessive polypharmacy were correlated with poorer cognitive and physical capability, with stronger associations seen for excessive polypharmacy.

Pre-Op Chronic Opioid Use Ups Poor Outcomes Post Spinal Fusion

April 02, 2018

The researchers found that 22.3% of patients had documented opioid use for more than 6 months before surgery, and 87.4% of these had continued long-term use postoperatively.

First-in-Class Inhibitor Designated Orphan Drug for Spinal Muscular Atrophy

By March 29, 2018

By inhibiting the activation of myostatin, SRK-015 may promote a clinically meaningful increase in muscle mass and strength.

MVPA Mortality Risk Reduction Not Tied to Exercise in Bouts

March 26, 2018

Physical activity data were processed to generate minutes/day of total and bouted MVPA, with bouted MVPA defined as MVPA accumulated in bouts of a minimum duration of five or 10 minutes.

Many Patients Receive Inappropriate Tests, Treatments for Low Back Pain

By March 22, 2018

More emphasis should be placed on self-management, physical and psychological therapies for treating low back pain, rather than pharmacological or surgical treatments.

Cimzia Label Update Provides New Information for Women of Childbearing Age

By March 22, 2018

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

Human neural stem cell grafts in rhesus monkeys improve motor function after injury

March 20, 2018

Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells.

Tamoxifen, Raloxifene Linked to Improvements in Muscular Dystrophy

March 20, 2018

Improvements include increase in grip force production, extended running time and distance

Abaloparatide Followed by Alendronate Ups BMD in Postmenopausal Women

By March 19, 2018

At the 43-month endpoint, a total of 60.7% (307/506) of the abaloparatide followed by alendronate group had ≥3% increase in bone mass at all 3 sites (P<0.0001) vs. 24% (121/505) of the placebo followed by alendronate group.

Febuxostat Linked to Increased Death Risk in Gout Patients With Heart Disease

March 12, 2018

Participants were followed for a median of 32 months.

Year-Long Study Assesses Opioid vs. Non-Opioid Tx for Back, Osteoarthritis Pain

March 07, 2018

The researchers observed no significant difference between the groups in pain-related function over 12 months (overall P=0.58); the mean 12-month Brief Pain Inventory (BPI) interference was 3.4 and 3.3 for the opioid and non-opioid groups, respectively.

Durolane Now Available to Treat Knee Osteoarthritis Pain

By March 05, 2018

In clinical trials, treatment with Durolane resulted in greater reduction in Visual Analog Scale (VAS) pain scores at 3 and 6 months compared to Synvisc One (hylan G-F 20; Sanofi Genzyme) (P<0.001).

Change in Diet May Cut Pain Associated With Gluten Neuropathy

March 01, 2018

The researchers observed no significant differences in terms of age, gender, neuropathy severity, and neuropathy type for patients with painful and not painful gluten neuropathy.

Menopausal Hormone Therapy May Aid in Reducing Spine Injury

February 23, 2018

The researchers found that, compared with never-users of HT, continuous users had a mean Cobb angle that was 4.0 degrees less, in minimally-adjusted models (P=0.01); in fully-adjusted models, the correlation was attenuated to 2.8 degrees (P=0.06).

Benefits of Rivaroxaban, Aspirin Compared After Hip, Knee Arthroplasty

February 22, 2018

The researchers found that venous thromboembolism occurred in 0.64 and 0.7% of patients in the aspirin and rivaroxaban groups, respectively (difference, 0.06 percentage points; 95% confidence interval [CI], −0.55 to 0.66; P<0.001 for noninferiority and P=0.84 for superiority).

Does Hydroxychloroquine Improve Symptoms of Hand Osteoarthritis?

By February 20, 2018

Findings do not support the current practice of off-label use of hydroxychloroquine for treating symptomatic hand osteoarthritis.

Nusinersen Beneficial in Children With Later-Onset Spinal Muscular Atrophy

February 15, 2018

Significant improvement in motor function compared with sham procedure among children with SMA