Musculoskeletal Disorders

Allopurinol Dose Escalation for Gout Does Not Improve Mortality

September 20, 2018

There was an increase in all-cause mortality among dose escalators (hazard ratio, 1.08; 95% confidence interval, 1.01 to 1.17). Similar effect sizes were seen for incidence of cardiovascular-related deaths (hazard ratio, 1.08; 95% confidence interval, 0.97 to 1.21) and cancer-related deaths (hazard ratio, 1.06; 95% confidence interval, 0.88 to 1.27).

Investigational Tx Shows Promise in Chronic Low Back Pain

By September 19, 2018

An investigational treatment - CAM2038 (Braeburn) - currently under review for the treatment of moderate-to-severe opioid use disorder, has demonstrated a reduction in Chronic Low Back Pain (CLBP) compared to placebo in patients previously on long-term daily opioid therapy.

Canakinumab administration tied to significant reduced risk for gout attacks

September 19, 2018

Canakinumab administration did not result in changes to serum uric acid levels.

Quarterly Canakinumab Reduces Risk for Gout Attacks

September 19, 2018

"These data have relevance for the development of agents for gout that target the interleukin-1β pathway of innate immunity," the authors write.

Many RA Patients' Pain Related to Central Nervous System

September 17, 2018

The investigators note that RA patients with increased levels of FMness seem to share neurobiologic features consistently observed in fibromyalgia patients.

Actemra SC Approved to Treat Active Systemic Juvenile Idiopathic Arthritis

By September 13, 2018

The approval of the SC formulation for this patient population was based on data from the JIGSAW-118 study, a 52-week, open-label, multicenter, pharmacokinetic (PK)/pharmacodynamic (PD) study.

Pharmacovigilance Needed for Rheumatology Patients

September 13, 2018

In order to actively monitor patients for adverse events, the ACR recognizes the role of health care providers, with reporting of any serious adverse events through MedWatch.

Investigational JAK1 Inhibitor Looks Promising in Phase 3 RA Study

By September 12, 2018

The 24-week Phase 3 trial randomized patients with moderate-to-severely active RA and prior inadequate response/intolerance to biologic agents to receive once-daily filgotinib 100mg, 200mg, or placebo.

Mediterranean Diet Tied to Lower Risk of Rheumatoid Arthritis

September 11, 2018

High adherence to the diet reduced the odds of developing RA by 21% (odds ratio [OR], 0.79; 95% confidence interval [CI], 0.65 to 0.96) vs low adherence (a score between 0 and 2), after adjusting for body mass index, educational level, physical activity, use of dietary supplements, energy intake, and smoking.

Patient Sues After Becoming Paralyzed Following Visit to Urgent Care

By September 10, 2018

Juries are notoriously unpredictable, and this case might have gone either way.

Out-of-Pocket Costs Similar for Infliximab, Infliximab-Dyyb

September 05, 2018

"Although biosimilar gap discounts begin in 2019, infliximab-dyyb may still not significantly reduce Part D beneficiaries' out-of-pocket costs given its high price and coinsurance cost-sharing similar to infliximab," the authors write.

Arthritis Treatments: DMARDS and Other Immune Modulators

August 29, 2018

A comparative list of treatment options for arthritis including DMARDS and other immune modulators.

Antirheumatic Indications: NSAIDs

August 29, 2018

Includes drugs indicated for different types of arthritis as well as the form and strength the medication is available in.

PT Better After Hip Surgery Than Opioids in Younger Adults

August 29, 2018

For patients receiving both treatments, the group receiving opioids first had mean hip-related downstream costs that were significantly higher than the group receiving physical therapy first ($18,806 versus $16,955).

TNFi Not Linked to Increased Cancer Recurrence in RA Patients

August 24, 2018

The researchers found that 42 of the 467 patients who started TNFi treatment at a mean of 7.9 years after cancer diagnosis had cancer recurrence (9.0%); 155 of 2,164 matched patients with the same cancer history had recurrences (7.2%).

Lower Post-Op Mortality With Hip Fx Surgery on Day of Admission

August 24, 2018

Cumulative 30-day in-hospital mortality was 4.9 and 6.9% among patients who were surgically treated on admission day and those who had surgery done after day 3.

DMD Treatment Gets Orphan Drug, Rare Pediatric Disease Designations

By August 17, 2018

DMD is predominately caused by out-of-frame deletions in the dystrophin gene, which results in absent or defective dystrophin protein, leading to progressive and irreversible muscle function loss.

Positive Results for Novel Osteoarthritis Pain Treatment in Phase 3 Trial

By August 16, 2018

Change in pain and physical function score from baseline were chosen as the co-primary endpoints.

Sedation Level Does Not Impact Delirium Risk After Hip Fx Repair

August 13, 2018

The researchers found that the overall incident delirium risk was 36.5%; 39 vs 34%, respectively, in the heavier and lighter sedation groups (P=.46).

Flu Vaccine Cuts Mortality in Rheumatoid Arthritis Patients

August 01, 2018

The researchers, after adjusting for potential confounding factors, found that RA patients who received the influenza vaccine had reduced risk of hospitalization for septicemia, bacteremia, or viremia.

Drop in Osteoporosis Treatment Initiation After Hip Fracture

July 27, 2018

The hospital preference instrumental variable had a stronger association with treatment than the other 3 instrumental variables (specialist access, calendar year, and geographic variation) during the effectiveness analyses.

Empagliflozin Does Not Up Risk of Bone Fractures

July 20, 2018

The researchers found that in the pooled analysis, bone fracture AEs were reported in 119 of 4221 patients (2.8%) randomized to empagliflozin 10mg, 105 of 4,196 patients (2.5%) randomized to empagliflozin 25mg, and 123 of 4203 patients (2.9%) randomized to the placebo group.

Both High and Low Uric Acid Levels Tied to Higher Mortality

July 19, 2018

The researchers found that over the study period (2,060,721.9 person-years), 2020 participants died, with 287 cardiovascular disease (CVD)-related deaths and 963 cancer deaths. Both low and high uric acid levels were associated with increased all-cause, CVD, and cancer mortality.

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

By July 18, 2018

The 16-week, double-blind, placebo-controlled, multicenter, parallel-group study included 698 patients who were randomized to 3 treatment groups: 2 doses of tanezumab 2.5mg; 1 dose of tanezumab 2.5mg followed by tanezumab 5mg, or 2 doses of placebo; each injection was administered once every 8 weeks.

Multiple Factors to Consider When Selecting NSAID for Arthritis

July 17, 2018

Although many NSAIDs must be taken every 4 hours, some come in long-acting or extended release forms. These can be taken as infrequently as once per day, which may be desirable for patients taking multiple medications.

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

By July 13, 2018

Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Mammography Use Tied to Other Preventive Tests in Older Women

July 09, 2018

The researchers found that women who underwent index screening mammography were more likely than unscreened women to later undergo Papanicolaou test (odds ratio, 1.49), bone mass measurement (odds ratio, 1.70), and influenza vaccine (odds ratio, 1.45).

Ezutromid Development Discontinued After DMD Trial Fails to Meet Endpoints

By June 28, 2018

Ezutromid, an oral utrophin modulator, was assessed in the 48-week PhaseOut DMD trial which included 40 boys with DMD.

USPSTF Issues Recommendation on Screening for Osteoporosis

June 28, 2018

Based on these findings, the USPSTF recommends screening for women aged 65 years and older and in younger women who have been through menopause and are at increased risk.

Muscle Spasm Treatments

June 26, 2018

Muscle spasm treatment chart with dosing regimens for muscle relaxants and other medications.