Behavioral features such as social communication, interactions, and restricted interest were most improved with bumetanide treatment; however, the authors reported no dose-effect relationship in the dose-ranging trial.
There was a correlation between more frequent in-person social contact and a significantly decreased risk for symptoms of major depression and posttraumatic stress disorder relative to contact every few weeks or less.
The researchers found that parents of an estimated 1.5 million US children aged 3 to 17 years (2.5%) reported their child had received a diagnosis and currently had ASD.
Parents of children with ASD reported higher demands for health care (i.e. were more likely to have seen a medical provider in the past year and have a personal doctor or nurse), but greater difficulty accessing services.
Participants were randomly assigned to a TM group (68 participants), prolonged exposure therapy (PE) group (68 participants), or an active control group of PTSD health education (HE; 67 participants).
"While we have been working hard to reduce burnout and increase access to mental health services for physicians and medical students, it is imperative that we also work toward fully understanding the problem," said AMA Board Member, Ryan Ribeira MD.
In this large systematic review and meta-analysis, the risk of suicide was 2 times higher for patients with history of at least 1 concussion or mild TBI.
NRX-101 combines D-cycloserine (DCS), an N-methyl-D-aspartate (NMDA) receptor antagonist, and lurasidone, a D2/5-HT2a receptor antagonist.
In pooled analyses of the 2 studies, consistently greater reduction was seen in MADRS scores from baseline for BUP/SAM 2mg/2mg versus placebo at multiple time points, including EOT and average change from baseline to week three through EOT.
In the meeting documents, the panel presented a scenario which illustrated their concerns regarding potentially complex drug interactions that may occur in the population for which the drug is intended.
Over time, there was an increase in the rates of mental health visits, from 50.4 to 78.5 per 100,000 children in 2012 and 2016, respectively.
The NPDX AA test works by detecting amine imbalances in a child's fasting blood sample with very precise thresholds that were identified and validated based on samples from the Children's Autism Metabolome Project (CAMP) study (N=1100) in patients aged 18 to 48 months
The highest odds ratios were seen for anxiety, panic attacks, and attention deficit hyperactivity disorder (odds ratios, 1.68, 1.61, and 1.4, respectively).
The researchers found that patients were exposed to a trial drug or placebo for a median duration of four days. The median number of days alive without delirium or coma was 8.5, 7.9, and 8.7 in the placebo, haloperidol, and ziprasidone groups (P=0.26 for overall effect across trial groups).
The designation was granted to COMPASS Pathways, a life sciences company investigating psilocybin in a Phase 2b trial involving 216 patients at multiple sites across Europe and North America.
In the 8-week, randomized, double-blind study, patients with depression who had TESD (N=447) while taking an SSRI (eg, paroxetine, sertraline or citalopram) were switched to Trintellix or escitalopram, due to SSRI-induced sexual dysfunction.
Among the 434,629 individuals included in the researcher, there were 2832 deaths due to alcohol, 3187 deaths due to accidents, and 853 deaths due to suicide during a mean follow-up of 7.1 years.
Compared with the active placebo, the infusions of ketamine were relatively well tolerated, except for greater dissociative symptoms and transient blood pressure elevations with the higher doses.
Among women not taking antihypertensives, sexual harassment was correlated with significantly increased odds of stage 1 or 2 hypertension (odds ratio, 2.36) as well as clinically poor sleep (odds ratio, 1.89) after adjustment for covariates.
The patient obtained prescriptions for bupropion XR from psychiatrists and primary care physicians who were not aware of her past medical history.
Higher risk for psychiatric diagnoses was predicted by high average HbA1c levels during the first 2 years of diabetes onset.
The researchers found that the mean number of guidelines met was 1.1; 51, 37, and 18% of participants met the daily recommendations for sleep time (9 to 11 hours/night), screen time (2 hours or less), and physical activity (60 minutes or more), respectively.
Lumateperone, a first-in-class molecule, works via potent interactions at 5-HT2A receptors, serotonin transporters, and D1 receptors with indirect glutamatergic modulation.
Currently, psilocybin, a serotonin receptor agonist, is classified as a Schedule I agent as it has not been approved by the Food and Drug Administration (FDA) for any therapeutic use.
The sNDA included findings from the RGH-MD-53, RGH-MD-54, and RGH-MD-56 trials in which cariprazine was associated with greater improvement in change from baseline to week 6 on the Montgomery Asberg Depression Rating scale (MADRS) total score vs placebo in bipolar I patients.
The primary outcome measure of the study was the frequency of any adverse psychiatric effect observed during treatment with one of these agents.