Mood Disorders

Physician Burnout Rates Vary by Medical Specialty

September 11, 2018

Nearly half of those in critical care, neurology, family medicine, ob-gyn, internal medicine report burnout

Treating Older Adult Bipolar Disorder: Newer Atypical Antipsychotics Compared

By September 10, 2018

While pharmacologic agents such as lithium and valproic acid have been shown to provide significant antimanic effects in older adults with bipolar disorder, an increase in the use of atypical antipsychotics in the general adult bipolar population prompted researchers to investigate the efficacy and tolerability of these agents in OABD.

Guidelines for Managing Perimenopausal Depression Now Available

By September 05, 2018

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

By September 04, 2018

The NDA includes five Phase 3 studies in patients with treatment-resistant depression: 3 short-term studies, 1 withdrawal maintenance of effect study, and 1 long-term safety study.

Self-Injury Tops Diabetes As Cause of Death in United States

September 04, 2018

The researchers found that in 2015, SIM surpassed diabetes as a cause of death in the United States. In 2016, the gap expanded, with rates of 29.1 and 24.8 per 100,000 population, respectively.

Remission of Schizophrenia Seen With Amisulpride, Clozapine

September 04, 2018

Overall, 45 and 44% on amisulpride and olanzapine, respectively, achieved remission (P=.87). Twenty-eight of the 40 patients not in remission started clozapine; 28% of the 18 patients who completed treatment achieved remission.

Risk of Depression Up in Autism Spectrum Disorder

September 04, 2018

The researchers found that by age 27 years, 19.8% of individuals diagnosed with ASD had a diagnosis of depression, compared with 6.0% among the general population (adjusted relative risk [RR], 3.64).

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

By August 22, 2018

The trial will be a Phase 2b dose-ranging study (N=216) with patients from 12-15 research centers across Europe and North America.

Midlife Deaths Increase in the United States

August 20, 2018

The researchers found that all-cause mortality increased among non-Hispanic (NH) whites, NH American Indians, and Alaskan Natives.

Traumatic brain injury associated with higher rate of suicide

August 16, 2018

In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.

Case: Hypertensive Crisis Following Use of Armodafinil + MAOI

By August 15, 2018

This case involved a 36-year-old female with bipolar disorder who presented to the emergency department (ED) with blurry vision, neck stiffness and the "worst headache of (her) life" after taking armodafinil with tranylcypromine.

Does Prenatal Tdap Vaccination Increase Autism Risk in Offspring?

By August 14, 2018

Currently, the Advisory Committee on Immunization Practices (ACIP) recommends pregnant women receive the Tdap vaccination to prevent pertussis infection.

Sedation Level Does Not Impact Delirium Risk After Hip Fx Repair

August 13, 2018

The researchers found that the overall incident delirium risk was 36.5%; 39 vs 34%, respectively, in the heavier and lighter sedation groups (P=.46).

Antidepressants and Bleeding Risk: What's the Link?

By August 08, 2018

Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.

CDC: Use of Unapproved Opioid-Like Antidepressant on the Rise in the US

By August 07, 2018

While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Medical Boards May Contribute to Mental Health Stigma for Doctors

July 31, 2018

Many state medical boards persist in questioning licensure applicants about their history of treatment for mental health instead of focusing on their current fitness to practice.

Phase 3 Trial of Potential PTSD Treatment Halted

By July 27, 2018

Participants in the trial were randomized to receive Tonmya 5.6mg sublingually at bedtime for 12 weeks or placebo sublingual tablets.

Off-Label Prescribing Common With Certain Psychiatric Medications

By July 26, 2018

Using data from the 2012 and 2013 National Ambulatory Medical Care Surveys, researchers looked at all adult outpatient visits to psychiatric practices for chronic care management in which ≥1 psychiatric medication was prescribed.

Prevalence of Depression 4.4% Among Dads of Infants

July 25, 2018

Overall, 4.4% of the fathers who answered the PSF screened positive for depression, which was comparable to the 5.0% of mothers who screened positive. Fathers accounted for 11.7% of all parents who screened positive for depression.

Escitalopram Cuts MACE Risk in Depressed Patients With ACS

July 25, 2018

Higher risk of major adverse cardiac events with concurrent depression after acute coronary syndrome

FDA Fast-Tracks Novel Treatment for Major Depressive Disorder

By July 23, 2018

AGN-241751 is being developed in tandem with rapastinel, an investigational intravenous formulation of a novel NMDA receptor partial agonist, currently in Phase 3 development for MDD, as both a monotherapy and an adjunctive treatment.

Greening Vacant Land Improves Neighborhood Mental Health

July 23, 2018

A total of 110 clusters were randomly assigned to the greening intervention, the trash cleanup intervention (removal of trash, limited grass mowing, and regular monthly maintenance), or a control group.

Can Omega-3 Fatty Acid Monotherapy Effectively Treat Adolescent Depression?

July 20, 2018

These results challenge existing conceptions that omega-3 fatty acids may be effective in treating adolescent major depressive disorder.

Withdrawal Symptoms Following SNRI Discontinuation Investigated

By July 19, 2018

Results showed that discontinuation of any SNRI was associated with withdrawal symptoms, with the highest prevalence linked to venlafaxine and desvenlafaxine.

Physician Burnout Tied to Higher Risk of Medical Errors

July 17, 2018

Physicians reporting errors were more likely to also report burnout, fatigue, recent suicidal ideation

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

By July 16, 2018

Currently, there are no approved treatments for behavioral symptoms (eg, aggression, agitation) in Alzheimer's disease.

Harmful Internet "Challenges" and Teens: A Guide for Primary Care Providers

July 12, 2018

Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

By July 10, 2018

The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

IT Solutions for Easier EHRs Save Physicians Time, Burnout

July 09, 2018

Three IT solutions are enabling Yale Medicine physicians to save hours of time. First, easier login identification, using badges to tap in and out of the EHR system throughout a shift, eliminates repetitive typing of the physician's username and password.

Efavirenz Use and Depression, Suicidal Ideation: Is There a Link?

June 26, 2018

The researchers found that depression or suicidal ideation did not differ at baseline for patients ever exposed to efavirenz versus those never exposed to efavirenz and receiving nevirapine.