Miscellaneous Urogenital Disorders

FDA Approves Expanded Prostate Cancer Indication for Xtandi

By July 16, 2018

The approval was based on data from the Phase 3 PROSPER trial which enrolled 1401 patients with non-metastatic CRPC.

Does Metformin Use Increase the Risk of Acidosis in CKD?

July 12, 2018

Time-dependent metformin use was not associated with incident acidosis overall or in those with eGFR 45 to 59 and 30 to 44 mL/min/1.73 m² (aHR, 1.16 [95% CI, 0.95 to 1.41] and 1.09 [95% CI, 0.83 to 1.44]) compared with alternative diabetes management.

Higher Visceral Fat Ratio Seen With Recurring Urolithiasis

July 09, 2018

However, there was no significant difference in visceral fat area (P=.32), subcutaneous fat area (P=.36), visceral fat volume (P=.38), or subcutaneous fat volume (P=.23).

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

July 05, 2018

Two devices designed to create arteriovenous fistula in patients with CKD in need of hemodialysis

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

July 02, 2018

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass

New Technique Allows Rapid Bedside Measurement of GFR

June 29, 2018

"The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility," the authors write.

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

By June 20, 2018

In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

By June 12, 2018

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Drug Use Tied to Early Death, Kidney Disease Progression

June 11, 2018

Over the study period, compared with non-smoking throughout follow-up, the multivariable-adjusted hazard ratios were 1.02 (95% confidence interval [CI], 0.86 to 1.21) for CKD progression and 1.86 (95% CI, 1.54 to 2.24) for all-cause mortality for persistent tobacco smoking.

Combo Therapy Appears Effective for Treating Subfertile Men

By June 06, 2018

To evaluate safety and efficacy of this therapy, study authors gathered data on patients treated with the combination from 2014 to 2017.

Positive Results Announced for First-in-Class Metabolic Acidosis Treatment

By June 05, 2018

After 12 weeks, 59.2% of patients treated with the study drug saw an increased blood bicarbonate of ≥4mEq/L or achieved a level in the normal range (22 to 29mEq/L) vs 22.5% of patients in the placebo group (primary endpoint; P <.0001).

Raviten Gets Fast Track Status for Intradialytic Hypotension Management

By May 29, 2018

Intradialytic hypotension is a common complication of hemodialysis and can lead to increased morbidity and mortality among patients with end-stage renal disease.

Yonsa Approved for Metastatic Castration-Resistant Prostate Cancer

By May 23, 2018

The approval of Yonsa was based on 2 randomized, placebo-controlled, multicenter Phase 3 studies in patients with mCRPC.

FDA: PD-L1 Blocking Agents Linked to Decreased Survival in Urothelial Cancer Trials

By May 21, 2018

Data Monitoring Committees (DMC) from two ongoing clinical trials (KEYNOTE-361 and IMVIGOR-130) found that in the monotherapy arms of these studies, patients with low PD-L1 status had decreased survival compared with those who received cisplatin- or carboplatin-based chemotherapy.

AUA: Most Women Report Dysfunctional Toileting Behaviors

May 21, 2018

Overall, 79.9, 64.5, and 97.8% reported premature voiding, straining to void, and delayed voiding, respectively.

Acute Kidney Injury in Hospital Ups Risk of Later Heart Failure

May 18, 2018

AKI was independently associated with higher rates of the composite outcome of hospitalization for heart failure and atherosclerotic events 1-year post-discharge.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Postresection intravesical gemcitabine decreases non-muscle-invasive urothelial CA recurrence

May 11, 2018

In this randomized controlled trial, time to recurrence was lower in patient with non-muscle-invasive urothelial cancer when treated with intravesical gemcitabine as compared to saline controls.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C

May 11, 2018

In patients with glomerular filtration rate (GFR) ≥45 mL/min/1.73 m² there was significant improvement in renal biomarkers, as indicated by a progressive increase in mean GFR values until 1 year.

Recent Oral Antibiotics Use Tied to Higher Risk of Nephrolithiasis

May 11, 2018

The strength of these associations was greatest for exposures at younger ages (P<.001) and 3 to 6 months before the index date (P<.001), with all but broad-spectrum penicillins remaining statistically significant 3 to 5 years from exposure.

Can coaching improve water intake, outcomes in those with chronic disease?

May 09, 2018

In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease.

Older Adults Agree Sex Is Important Part of Relationships

May 03, 2018

Forty percent indicated that they were currently sexually active; sexual activity decreased with age. More than half (54%) of respondents agreed that sex is important to their overall quality of life, with men more likely to agree than women (70 versus 40%).

Opioids Tied to Adverse Outcomes in Hemodialysis Patients

April 20, 2018

There was a correlation for opioid use with risk for all outcomes in a dose-dependent manner: altered mental status, fall, and fracture.

New Staging System Predicts CKD Progression in Children

April 11, 2018

"CKD staged by level of eGFR and proteinuria characterizes the timeline of progression and can guide management strategies in children," the authors write.

Caffeine Citrate Helps Reduce Acute Kidney Injury in Preemies

April 04, 2018

The researchers found that AKI occurred in 18.1% of neonates in the first seven days after birth and occurred less frequently among neonates who received caffeine versus those who did not (11.2 versus 31.6%; P<0.01).

Trained Navigators Help Patients With Kidney Transplant Process

March 27, 2018

Time from referral to waitlisting was 126 days longer for intervention patients. While there was no difference in waitlisting in the early period between intervention and control patients (hazard ratio, 1.03; 95% confidence interval, 0.69 to 1.53), intervention patients were 3.3 times more likely to be waitlisted after 500 days.

Low Sperm Count Associated With Worse Cardiometabolic Health

March 19, 2018

Low sperm counts linked to hypogonadism, higher BMI, hypertension, dyslipidemia, metabolic syndrome

CDC: Acute Kidney Injury Hospitalization Rates Examined in the U.S.

By March 16, 2018

For the report, AKI was defined as the occurrence of at least 1 diagnostic code 584 (acute renal failure) or the occurrence of at least 1 procedure code of 39.95 (hemodialysis) or 54.98 (peritoneal dialysis).

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill

March 06, 2018

Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients.

Balanced Crystalloids May Cut Kidney Complications Compared With Saline

By February 28, 2018

The results showed no difference in the number of hospital-free days between either group but the balanced crystalloids group had a lower incidence of major adverse kidney events ≤30 days vs the saline group.