Miscellaneous Urogenital Disorders

Chronic Kidney Disease Burden Increasing in the US

December 07, 2018

The researchers found that during the study period, CKD disability-adjusted life years increased by 52.6%. Death due to CKD increased by 58.3%, from 52,127 to 82,539 deaths.

Exposure to Phthalates May Impact Timing of Puberty

December 05, 2018

Exposure to certain endocrine-disrupting chemicals may impact the timing of puberty in children.

Zoliflodacin found to effectively treats urogenital gonorrhea

November 08, 2018

Patients with uncomplicated urogenital gonorrhea treated with the novel antibiotic zoliflodacin, developed in part due to increasingly antibiotic resistant gonorrhea, were cured at rates similar to that seen in patients treated with ceftriaxone.

Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

November 02, 2018

"We believe that the data actually suggest possible benefit for ESKD [end-stage kidney disease] with intensive glucose control, and remain inconclusive for intensive blood pressure control and fibrate use given the wide confidence intervals for the more reliable ESKD outcomes," write the authors.

Contepo NDA Submitted for Treatment of Complicated UTI

By November 01, 2018

Contepo, an investigational epoxide intravenous (IV) antibiotic, has broad spectrum activity against Gram-negative and Gram-positive pathogens, including multi-drug resistant strains such as ESBL-producing Enterobacteriaceae.

High-Dose, Proactive IV Iron Noninferior in Hemodialysis

November 01, 2018

The researchers found that patients received a median monthly iron dose of 264 and 145mg in the high- and low-dose groups, respectively.

Mitomycin Gel Granted Breakthrough Tx Designation for Urothelial Cancer

By October 31, 2018

UGN-1 is an investigational formulation of mitomycin, delivered to patients using standard intravesical catheters.

High-Dose Flu Vaccine May Cut Hospitalization in Dialysis Patients

October 24, 2018

The researchers found that by vaccine type, the adjusted rates of first hospitalization were 8.43, 7.88, and 7.99 per 100 patient-months, respectively, and rates for death were 1.00, 0.97, and 1.04, respectively; these differences were not significant.

Early, delayed renal-replacement examined in septic shock associated acute kidney injury

October 19, 2018

Among patients with septic shock and acute kidney injury, there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT).

Posttransplant Outcomes Assessed in Patients Who Resumed TNFi Therapy

By October 18, 2018

Of the 5256 patients who received a renal transplant in the study window (1/1/1998 - 12/31/2017), 14 met inclusion criteria.

Effect of Renal-Replacement Timing Examined in Kidney Injury, Sepsis

October 11, 2018

After the second planned interim analysis, the trial was stopped early for futility. The researchers found that 58% of patients in the early-strategy group and 54% in the delayed-strategy group had died (P= 0.38).

Patients Report Poorer Dialysis Service in Certain Settings

September 24, 2018

Larger proportions of the overall between-facility variation in ICH-CAHPS scores were explained by geographic location and dialysis facility characteristics than patient characteristics.

Hydralazine Linked to Amenorrhea in Premenopausal Patient

By September 18, 2018

This case highlights a possible relationship between the administration of hydralazine and the development of amenorrhea.

Caffeine Consumption Appears to Reduce the Risk of Death in CKD Patients

By September 12, 2018

Using data from the National Health and Nutrition Examination Survey (1999-2010), researchers evaluated caffeine consumption among 4863 non-institutionalized adults with CKD to determine the association between caffeine intake and mortality in these patients.

Lower patient satisfaction reported at for-profit dialysis centers

September 11, 2018

Patient reported experience has recently been incorporated into Quality Incentive Programs for dialysis centers across the United States. Lower patient experience scores were reported in for-profit, free-standing, and large dialysis organization centers.

Efficacy, Safety of PSA Testing for Prostate Cancer Screening Investigated

September 06, 2018

Odds of choosing screening up for men with family history, African descent, low socioeconomic status

Nalbuphine Can Relieve Opioid-Induced Urine Retention

September 04, 2018

During the first 6 hours after receiving the drug, the patient voided 850mL, and pain remained controlled. On ultrasonography, bladder volume was 77mL one day later.

Keytruda, Tecentriq Labeling Updated With PD-L1 Testing Requirements

By August 17, 2018

The Dako PD-L1 IHC 22C3 PharmDx Assay has been approved as a companion diagnostic to identify patients with with locally advanced or metastatic urothelial carcinoma who are cisplatin-ineligible for treatment with Keytruda.

Vicinium Fast-Tracked for Non-Muscle Invasive Bladder Cancer

By August 10, 2018

A Phase 3 trial (Vista) of the treatment is currently taking place; the trial is evaluating the treatment in patients with NMIBC who have previously received 2 courses of BCG and who are now BCG-unresponsive.

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

August 07, 2018

"In summary, this trial provides reassuring (albeit preliminary) evidence that kidneys from HCV-infected donors may be safely transplanted into HCV-negative recipients," the authors write.

Tamsulosin Does Not Appear to Promote Urinary Stone Passage

August 01, 2018

The researchers found that stone passage rates were 50% in the tamsulosin group and 47% in the placebo group (relative risk, 1.05; 95.8% confidence interval, 0.87 to 1.27; P=.60).

FDA Clears Smartphone-Enabled Urinalysis Kit for Home Use

By July 25, 2018

The Dip.io kit works in tandem with existing smartphone cameras and a dedicated app.

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

By July 17, 2018

A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.

FDA Approves Expanded Prostate Cancer Indication for Xtandi

By July 16, 2018

The approval was based on data from the Phase 3 PROSPER trial which enrolled 1401 patients with non-metastatic CRPC.

Does Metformin Use Increase the Risk of Acidosis in CKD?

July 12, 2018

Time-dependent metformin use was not associated with incident acidosis overall or in those with eGFR 45 to 59 and 30 to 44 mL/min/1.73 m² (aHR, 1.16 [95% CI, 0.95 to 1.41] and 1.09 [95% CI, 0.83 to 1.44]) compared with alternative diabetes management.

Higher Visceral Fat Ratio Seen With Recurring Urolithiasis

July 09, 2018

However, there was no significant difference in visceral fat area (P=.32), subcutaneous fat area (P=.36), visceral fat volume (P=.38), or subcutaneous fat volume (P=.23).

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

July 05, 2018

Two devices designed to create arteriovenous fistula in patients with CKD in need of hemodialysis

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

July 02, 2018

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass

New Technique Allows Rapid Bedside Measurement of GFR

June 29, 2018

"The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility," the authors write.

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

By June 20, 2018

In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.