Miscellaneous Respiratory Disorders
Multivariable predictors included oxygen saturation <90%, nasal flaring and/or grunting, apnea, retractions, age ≤2 months, dehydration, and poor feeding (odds ratios, 8.9, 3.8, 3.0, 3.0, 2.1, 2.1, and 1.9, respectively).
The primary objective was to characterize the long-term safety and tolerability of Ofev in patients with IPF; efficacy endpoints included annual rate of decline in forced vital capacity (FVC) calculated over 192 weeks.
The FDA's designation was based on data from a Phase 2 placebo-controlled trial that demonstrated pamrevlumab could potentially address an unmet medical need for this condition.
The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.
Liquid nitrogen isn't toxic, but its extremely low temperature can cause severe damage to skin and internal organs if mishandled or consumed, the FDA said in a news release.
Those at highest risk from the recalled products include infants, children, pregnant women, and people with weakened immune systems, the FDA said.
It predicts between 470 and 1,400 premature deaths a year by 2030 because of increased levels of microscopic airborne particulates, which are linked with heart and lung disease and chronic problems like asthma and bronchitis, The Times reported.
The median OS was not reached at the time of the data cut-off in the pembrolizumab plus chemotherapy arm and was 11.3 months for those in the chemotherapy arm.
Data showed that 12% responded to treatment based on assessment by a Blinded Independent Central Review, regardless of PD-L1 expression; 11% had a partial response, and 1 patient had a complete response (0.9%).
Bronchiolitis obliterans is the leading cause of morbidity and mortality in the pulmonary transplant population with ≥50% of patients who receive a lung transplant developing the condition within 5 years.
The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.
The recommendation was supported by materials developed from the ALIS New Drug Application (NDA), which included data from the CONVERT study.
Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events
Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.
In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.
To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).
Timely review and appropriate follow up on all patient reports is essential and must be part of a practice's routine.
Participants were evaluated in linked national registers up to 2009, and incidence of disease was examined up to age 30 years, with adjustment for 18 covariates.
The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis.
Slower annual rates of decline were seen in FEV1 and FVC for participants with the highest quartile of anthocyanin intake (−9.8mL/year for both). The FEV1/FVC ratio decline was also slower for the highest versus the lowest quartile of anthocyanin intake (−0.02/year).
"Distinct immune-response clusters during infant RSV infection and their association with risk of recurrent wheeze provide insights into the risk factors for and mechanisms of asthma development," the authors write.
Evaluators were able to match the correct 3-D nose to the corresponding volunteers' photographs in 171 of 175 photographs (97.7%).
The clinic claims its unapproved therapies can treat a number of serious diseases and conditions, including Parkinson's disease, amyotrophic lateral sclerosis (ALS), chronic obstructive pulmonary disease (COPD), heart disease, and pulmonary fibrosis.
The chemical residue from cigarette smoke that attaches to anything and anyone in the vicinity of a smoke cloud, can still make its way into the air of buildings that currently have a non-smoking designation.