Miscellaneous Respiratory Disorders

Factors Predictive of Escalated Care in Infant Bronchiolitis ID'd

September 18, 2018

Multivariable predictors included oxygen saturation <90%, nasal flaring and/or grunting, apnea, retractions, age ≤2 months, dehydration, and poor feeding (odds ratios, 8.9, 3.8, 3.0, 3.0, 2.1, 2.1, and 1.9, respectively).

Ofev Slows Idiopathic Pulmonary Fibrosis Progression Long-Term

By September 17, 2018

The primary objective was to characterize the long-term safety and tolerability of Ofev in patients with IPF; efficacy endpoints included annual rate of decline in forced vital capacity (FVC) calculated over 192 weeks.

FDA Fast-Tracks Pamrevlumab for Idiopathic Pulmonary Fibrosis

By September 12, 2018

The FDA's designation was based on data from a Phase 2 placebo-controlled trial that demonstrated pamrevlumab could potentially address an unmet medical need for this condition.

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

By September 11, 2018

The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

FDA Warns of Dangers of Liquid Nitrogen in Food, Drinks

September 04, 2018

Liquid nitrogen isn't toxic, but its extremely low temperature can cause severe damage to skin and internal organs if mishandled or consumed, the FDA said in a news release.

FDA: Hundreds of Human, Pet Homeopathy Products Recalled

August 29, 2018

Those at highest risk from the recalled products include infants, children, pregnant women, and people with weakened immune systems, the FDA said.

Glucocorticoid Therapy Examined in Pediatric Patients With Croup

By August 23, 2018

Forty-three randomized controlled trials (N=4565) were included in the analysis, 5 more than in the previous review.

Plan to Relax Coal-Fired Power Plant Rules Could Up Mortality

August 22, 2018

It predicts between 470 and 1,400 premature deaths a year by 2030 because of increased levels of microscopic airborne particulates, which are linked with heart and lung disease and chronic problems like asthma and bronchitis, The Times reported.

Keytruda With Pemetrexed + Platinum Chemotherapy OK'd for Nonsquamous NSCLC

By August 21, 2018

The median OS was not reached at the time of the data cut-off in the pembrolizumab plus chemotherapy arm and was 11.3 months for those in the chemotherapy arm.

Opdivo Approved to Treat Metastatic Small Cell Lung Cancer

By August 20, 2018

Data showed that 12% responded to treatment based on assessment by a Blinded Independent Central Review, regardless of PD-L1 expression; 11% had a partial response, and 1 patient had a complete response (0.9%).

Treatment for Bronchiolitis Obliterans Gains Orphan Drug Status

By August 15, 2018

Bronchiolitis obliterans is the leading cause of morbidity and mortality in the pulmonary transplant population with ≥50% of patients who receive a lung transplant developing the condition within 5 years.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

By August 09, 2018

The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

FDA Panel Votes on Therapy for Nontuberculous Mycobacterial Lung Disease

By August 09, 2018

The recommendation was supported by materials developed from the ALIS New Drug Application (NDA), which included data from the CONVERT study.

Anti-Fibrotic Drug Gets Orphan Drug Status for Idiopathic Pulmonary Fibrosis

By August 07, 2018

Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events

FDA: Cancer Relapse Linked to Azithromycin Use to Prevent Serious Lung Condition

By August 03, 2018

Pfizer has terminated the ALLOZITHRO trial (N=480) due to this increased risk.

Harmful Internet "Challenges" and Teens: A Guide for Primary Care Providers

July 12, 2018

Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

By July 11, 2018

In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.

Is Short-Course Antibiotic Treatment for CAP Effective?

By July 11, 2018

To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

Physician Sued by Noncompliant Patient After Failing to Follow Up on Test

By July 10, 2018

Timely review and appropriate follow up on all patient reports is essential and must be part of a practice's routine.

Smoking Marijuana May Be Tied to Cough, Sputum Production

July 03, 2018

Insufficient evidence for link between marijuana and pulmonary function, obstructive lung disease

Zephyr Valve Approved for Treating Patients With Severe Emphysema

By July 02, 2018

The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.

Adenoid, Tonsil Removal May Affect Later Respiratory Risks

June 08, 2018

Participants were evaluated in linked national registers up to 2009, and incidence of disease was examined up to age 30 years, with adjustment for 18 covariates.

Recombinant human pentraxin 2 slows the decline in lung function in idiopathic pulmonary fibrosis

June 07, 2018

The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis.

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

May 23, 2018

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Slower Decline in Lung Function With Anthocyanin Intake

May 22, 2018

Slower annual rates of decline were seen in FEV1 and FVC for participants with the highest quartile of anthocyanin intake (−9.8mL/year for both). The FEV1/FVC ratio decline was also slower for the highest versus the lowest quartile of anthocyanin intake (−0.02/year).

Two Novel Immune-Response Clusters Identified to RSV

May 18, 2018

"Distinct immune-response clusters during infant RSV infection and their association with risk of recurrent wheeze provide insights into the risk factors for and mechanisms of asthma development," the authors write.

Can 3-D Printing Create Temporary Prosthesis, Cut Out Prosthodontist?

May 15, 2018

Evaluators were able to match the correct 3-D nose to the corresponding volunteers' photographs in 171 of 175 photographs (97.7%).

FDA Targets Clinics Offering Unapproved Stem Cell Therapies

May 11, 2018

The clinic claims its unapproved therapies can treat a number of serious diseases and conditions, including Parkinson's disease, amyotrophic lateral sclerosis (ALS), chronic obstructive pulmonary disease (COPD), heart disease, and pulmonary fibrosis.

Novel Thirdhand Smoke Exposure Route Identified

May 11, 2018

The chemical residue from cigarette smoke that attaches to anything and anyone in the vicinity of a smoke cloud, can still make its way into the air of buildings that currently have a non-smoking designation.

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

By April 16, 2018

Continuous positive airway pressure (CPAP) remains the mainstay of medical treatment for OSA.