Miscellaneous Ob/Gyn Conditions

Quadrivalent HPV Vaccine Not Tied to Spontaneous Abortion

July 17, 2018

No evidence of increased risk of spontaneous abortion when inadvertently given before or during pregnancy

Placebo Effect of Various Female Sexual Dysfunction Drug Txs Assessed

By July 12, 2018

For this study, the authors aimed to quantify this effect by conducting a systematic review of various databases to identify studies that included a placebo arm and used Female Sexual Function Index as a clinical outcome.

Labeling for Nausea Drugs Used During Pregnancy Updated With New Warning

By June 27, 2018

The Warnings and Precautions section for both products has been updated to inform clinicians that there have been reports of false positive urine screening tests for methadone, opiates, and phencyclidine phosphate (PCP) with doxylamine succinate/pyridoxine hydrochloride use.

Neonatal neuroimaging and predictive value for developmental outcomes

June 26, 2018

In multivariate analyses, adverse late cranial ultrasound findings (CUS) were an independent risk factor for full scale IQ scores 70 (FSIQ 70). Adverse late cranial ultrasound findings and adverse findings on MRI were independent risk factors for moderate-to-severe disability (MTSD).

Early Preterm Birth Linked to Increased ADHD Symptoms

June 26, 2018

The correlation between gestational age at birth and symptoms of ADHD in preschool and school-age children was compared after adjustment for unmeasured genetic and environmental risk factors.

No Causal Effect of 25(OH)D on Gestational HTN, Preeclampsia

June 21, 2018

"No strong evidence was found to support a causal effect of vitamin D status on gestational hypertension or preeclampsia," the authors write.

Some Neonatal Risks for Lithium Exposure in Pregnancy

June 20, 2018

Compared with the reference group, lithium-exposed pregnancies had an increased risk for neonatal readmission (27.5 vs 14.3%; pooled adjusted odds ratio, 1.62).

Female Libido Treatment to Relaunch With Large Price Reduction

By June 15, 2018

Controversy has surrounded Addyi since its launch in 2015, after it faced the FDA's advisory committee panel for review of efficacy and safety issues a total of 3 times before approval.

Mifepristone Pre-Tx Improves Management of Early Miscarriage

June 07, 2018

The researchers found that 83.8% of 148 women in the mifepristone-pretreatment group and 67.1% of 149 women in the misoprostol-alone group had complete expulsion after 1 dose of misoprostol (relative risk, 1.25).

Microbiota in Breastfed Infants May Help Prevent Overweight

June 06, 2018

The researchers found that in covariate-adjusted models, infants who were exclusively formula-fed at 3 months had increased risk of overweight (adjusted odds ratio, 2.04; 95% confidence interval, 1.25 to 3.32).

Ob-Gyns Should ID Gynecologic Symptoms of Eating Disorders

June 01, 2018

Formal diagnosis and treatment of eating disorders in adolescents are outside the scope of gynecologic practice, but health care providers should be comfortable with recognizing and screening at-risk patients.

Abortion Not Tied to Significantly Higher Antidepressant Use

June 01, 2018

Comparing women who had an abortion with women who did not have an abortion, the fully-adjusted incidence rate ratios (IRRs) were not statistically significantly different in the year before the abortion and the year after the abortion.

Most Premature Infants Receive Early Antibiotics

May 30, 2018

"The variability in exposure rates across centers, however, suggests that neonatal antimicrobial stewardship efforts are warranted to optimize antibiotic use for VLBW and ELBW infants," the authors write.

Is Cetirizine Use During Pregnancy Linked to Adverse Outcomes?

By May 21, 2018

To assess pregnancy outcomes associated with CTZ use, a retrospective analysis was conducted using the UCB Pharma Patient Safety Database to search for pregnancies up to February 28th, 2015.

Fetal Growth, Maternal Anger Impact Infant Regulation

May 16, 2018

"The study adds to the sparse literature on joint effects of tobacco and marijuana, and highlights the role of fetal growth and maternal anger as important pathways from prenatal risk to infant RR," the authors write.

Ob-Gyns Should Play Role in Reducing CVD Risk for Women

May 10, 2018

The authors note that most women consider their ob-gyn to be their primary care physician.

Low Procedure Volume for Many Surgeons Doing Hysterectomies

May 10, 2018

For very low-volume surgeons, the overall complication rates were 32.0%, compared to 9.9% for those treated by other surgeons (P<.001; adjusted relative risk, 1.97).

Irregular Menstruation Common in Girls With Type 2 Diabetes

April 30, 2018

These findings persisted after adjusting for body mass index. Treatment group had no effect on menses or sex steroids at 12 or 24 months. Furthermore, there was no association between sex steroids and measures of insulin sensitivity or secretion.

Risk of Adverse Birth Outcomes No Higher With TDF-FTC-LPV/r

April 26, 2018

The researchers compared the risks of adverse birth outcomes among infants with in utero exposure to the 3 regimens, using data from two U.S.-based cohort studies.

ACOG: Revised Committee Opinion on Postpartum Care Released

By April 25, 2018

Previously, ACOG had recommended a comprehensive postpartum visit occur within the first 6 weeks after birth.

USPSTF Urges Abuse Screening for Reproductive-Aged Women

April 25, 2018

The researchers found that there was adequate evidence that available screening instruments can identify intimate partner violence in women.

In Utero Caffeine Exposure Affects Early Childhood Weight

April 24, 2018

The researchers found that, compared with pregnant women with low caffeine intake (<50mg/day; 46%), women with average (50 to 199mg/day; 44%), high (≥200 to 299 mg/day; 7%), and very high (≥300mg/day; 3%) caffeine intakes had an increased risk of their child experiencing excess growth in infancy.

NDA Submitted for Postpartum Depression Treatment Brexanolone

By April 23, 2018

Results in the 202B and 202C trials showed that brexanolone achieved the primary endpoint of mean reduction from baseline in the Hamilton Rating Scale for Depression.

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

April 11, 2018

Compared to the placebo group, the caffeine group performed better in fine motor coordination (P=0.01), visuomotor integration (P<0.05), visual perception (P=0.02), and visuospatial organization (P=0.003).

Cannabis Compound Transfers to Breast Milk

April 10, 2018

The researchers found that delta-9-tetrahydrocannabinol was detected at low concentrations at all the time points beyond time 0, but no metabolites were detected at any time point.

Prenatal Exposure to SSRI Tied to Fetal Brain Development

April 10, 2018

Compared with both healthy controls and infants exposed to untreated maternal depression, significant gray matter volume expansion was seen in the right amygdala and right insula in SSRI-exposed infants in voxel-based morphometry.

Factors ID'd for Breastfeeding Behavior in Women With BMI &#8805;30

April 06, 2018

Five factors correlated with breastfeeding behaviors: intentions to breastfeed; belief in the nutritional adequacy and sufficiency of breast milk; belief about others' infant feeding preferences; body image; and social knowledge.

Bonjesta Now Available to Treat Nausea and Vomiting of Pregnancy

By April 02, 2018

Bonjesta is a multilayer, extended-release formulation that is designed to provide both fast-acting and long-lasting symptom relief.

Infant Heart Defects May Be Early Marker of Future CVD in Mothers

April 02, 2018

There were 3.38 cardiovascular hospitalizations per 1,000 person-years for mothers with infants with critical defects, 3.19 for mothers of infants with noncritical defects, and 2.42 for mothers of infants with no heart defects.

Complete Genome Sequence Can Be ID'd From Amniotic Fluid

March 27, 2018

The researchers found that concordance of variant calls exceeded 96% between the 2 DNA sources and with parental libraries.