Methylphenidate CII

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Sleep-wake disorders
Only 4 drugs may be compared at once

Generic Name and Formulations:

Methylphenidate HCl 5mg, 10mg+, 20mg+; tabs; dye-free; +scored.

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Indications for Methylphenidate:

Attention deficit hyperactivity disorder.


10–60mg daily in 2–3 divided doses preferably 30–45 mins before meals. Chew tabs: take with 8oz of water or other fluid.


<6yrs: not established. ≥6yrs: initially 5mg twice a day before breakfast and lunch. Increase gradually by 5–10mg per week if needed; max 60mg daily.


During or within 14 days of MAOIs. Marked anxiety, tension, agitation. Glaucoma. Motor tics. Tourette's syndrome in patient or family.

Boxed Warning:

Drug abuse and dependence.


History of drug dependence or alcoholism; monitor for abnormal behavior. Increased risk of sudden death, stroke, and MI; assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Pre-existing psychotic disorder. Bipolar disorder; screen for risk before initiation. Consider discontinuing if new psychotic/manic symptoms occur. Monitor for new or worsening aggressive behavior or hostility. Seizure disorder. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Monitor growth (esp. children), BP, HR, CBCs, differential, platelet counts. Reduce dose or discontinue if paradoxical aggravation of symptoms occur. Reevaluate periodically. Pregnancy (Cat.C). Nursing mothers.

See Also:



Methylphenidate Extended-Release

Pharmacological Class:

CNS stimulant.


See Contraindications. Caution with pressor agents, anticonvulsants. May increase levels of anticonvulsants, oral anticoagulants, tricyclics, phenylbutazone. Antagonizes guanethidine, other antihypertensives. Risk of serotonin syndrome with serotonergic drugs.

Adverse Reactions:

Insomnia, nervousness, CNS overstimulation, anorexia, weight loss, abdominal pain, nausea, dizziness, headache; priapism, hypertension, tachycardia, visual disturbances.

How Supplied:

Tabs, ext-rel tabs—contact supplier; Chew tabs—100; Oral soln—500mL

Indications for Methylphenidate: