Metabolic Disorders

Primary Care Providers Have Mixed Views on Genetic Tests

May 14, 2018

They find tests for genetic risk potentially useful, but lack confidence in interpreting results

FDA Committee in Favor of Waylivra for Rare Metabolic Lipid Disorder

By May 11, 2018

Antisense technology refers to the use of synthetic nucleic acid sequences to interrupt specific protein production by targeting the corresponding messenger RNA that encodes that protein.

Lesbian, Bi Women More Likely to Develop T2DM at Younger Age

May 09, 2018

Higher BMI in lesbian and bisexual women is an important contributor to the greater level of type 2 diabetes among this population, the authors found.

Improved research methods needed to determine effectiveness of anti-obesity public health initiatives

May 02, 2018

Researchers found that amongst nearly 300 studies reporting the impact of policies, programs, or changes in built environment on controlling and preventing obesity, most natural experiments had high risk of bias and poor handling of dropouts and withdrawals.

Severe Obesity Tied to Faster Progression to Disability With RA

May 01, 2018

The researchers found that at baseline, severely obese patients had higher disability scores versus overweight patients in both Forward and VARA.

Review: Need to Strengthen Natural Experiments in Obesity

May 01, 2018

In terms of study design, guidance, documentation, and communication about methods used should be improved. Cross-cutting recommendations are provided for improving the rigor of natural experiments in obesity.

First FDA-Approved Treatment for X-Linked Hypophosphatemia Launched

By April 30, 2018

Crysvita, a recombinant fully human monoclonal IgG1 antibody, works by blocking fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses vitamin D production by the kidney.

Family-Based Treatment of Teen Eating Disorders Helpful

April 30, 2018

The researchers found that on average, patients and their parents perceived FBT as "quite helpful" and "extremely helpful," respectively.

About 40 Percent of Men Report Experiencing Weight Stigma

April 25, 2018

Weight stigma was associated with increased odds of having a body mass index (BMI) consistent with underweight or obesity compared with normal weight.

Lonafarnib May Lower Mortality in Hutchinson-Gilford Progeria

April 25, 2018

Patients were treated for a median of 2.2 years. The researchers found that the primary cause of death was heart failure (79.4%), when identified. One death (3.7%) occurred among the 27 patients in the first trial group; among the 27 patients in the matched untreated group, there were 9 deaths (33.3%).

Preteens Metabolically Comparable to Trained Athletes

April 24, 2018

The researchers observed no significant difference in the Pmax-to-PVO2max ratio between children and endurance athletes (1.9 ± 0.5 versus 2.1 ± 0.2); the ratio was lower than that of untrained men (3.2 ± 0.3).

Factors ID'd to Predict Fatty Liver in Obese Teens

April 24, 2018

"The combination of ethnicity/race with markers of insulin resistance and genetic factors might help identify obese youth at risk for developing fatty liver," the authors write.

FDA Approves Generic Therapy for Type 1 Gaucher Disease

By April 23, 2018

Miglustat, a glucosylceramide synthase inhibitor, is indicated as monotherapy for the treatment of adults with mild to moderate type 1 Gaucher disease for whom enzyme replacement therapy is not a therapeutic option (eg, due to allergy, hypersensitivity, or poor venous access).

Crysvita Approved for the Treatment of X-Linked Hypophosphatemia

By April 17, 2018

Crysvita is an antibody that blocks fibroblast growth factor 23 (FGF23), a hormone that causes phosphate urinary excretion and suppresses active vitamin D production by the kidney.

Elamipretide Granted Orphan Drug Status for Barth Syndrome

By April 09, 2018

The TAZPOWER study is a randomized, double-blind, placebo-controlled Phase 2/3 crossover study evaluating the safety and efficacy of elamipretide (daily subcutaneous injections) in 12 male patients (aged ≥12 years) with genetically-confirmed Barth syndrome.

Obesity Can Negatively Affect Liver in Children As Young As 8

April 06, 2018

Each additional 10cm greater waist circumference at early childhood was associated with 1.99 higher odds of elevated ALT at mid-childhood, in multivariable-adjusted models.

Novel Cystic Fibrosis Treatment Granted Fast Track Status

By April 04, 2018

Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).

Change in BMI During Puberty Tied to Later Heart Failure Risk

March 30, 2018

Compared with boys who were neither overweight during childhood or puberty, boys developing overweight during puberty had increased risk of heart failure.

Recent Years Have Seen Obesity Prevalence Increasing for Adults

March 28, 2018

Increases in prevalence were seen for women, adults aged 40 to 59 years, and 60 years or older. The age-standardized prevalence of severe obesity increased significantly from 5.7% in 2007 to 2008 to 7.7% in 2015 to 2016

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

March 28, 2018

No residual effect for past users, including early discontinuers of menopause hormone treatment

Cryoablation of Posterior Vagal Trunk Feasible in Obesity

March 23, 2018

Technical success rate 100 percent in 10 subjects; no procedure-related complications, adverse events

Significant Weight Loss Seen With Once-Daily Semaglutide in Obese Adults

By March 19, 2018

Novo Nordisk is planning on initiating a Phase 3 trial of semaglutide that will include 4,500 individuals who are overweight or obese sometime in 2018. Semaglutide is currently not approved for treatment of obesity.

Low Sperm Count Associated With Worse Cardiometabolic Health

March 19, 2018

Low sperm counts linked to hypogonadism, higher BMI, hypertension, dyslipidemia, metabolic syndrome

How Does Medical Tx Compare To Bariatric Surgery in Obese Diabetes Patients?

March 14, 2018

The researchers found that the mean hemoglobin A1c concentration decreased from 6.8 to 5.5% in Teen-LABS and increased from 6.4 to 7.8% in TODAY participants during 2 years.

Increased Offspring BMI Tied to Metformin Exposure In Utero

March 01, 2018

The researchers found that at age 4 years there was a non-significant difference in height z-scores between children of women randomized to placebo and those randomized to metformin.

Sex Specific Relationship Between Obesity and Myocardial Infarction Examined

February 28, 2018

During 7 years of follow-up, the researchers identified 5,710 cases of MI among 265,988 women and 213,622 men without a history of cardiovascular disease at baseline. In both sexes, there was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI.

Infant Gut Microbiota May Mediate Intergenerational Transmission of Obesity

February 22, 2018

The researchers found that infants born vaginally to overweight or obese mothers were significantly more likely to become overweight at age 1 year, compared with being born vaginally to a normal-weight mother (adjusted odds ratio, 3.33).

Obese Individuals May Have Greater Metastatic Melanoma Survival Odds

February 21, 2018

The obesity-related survival benefit was seen only for patients receiving targeted therapy (hazard ratios, 0.72 and 0.6 for progression-free and overall survival, respectively) and immunotherapy (hazard ratios, 0.75 and 0.64, respectively), not for patients receiving chemotherapy.

USPSTF: Obese Patients Should Be Referred to Multicomponent Behavioral Interventions

February 21, 2018

Draft recommendation statement concludes that doctors should provide, refer adults to interventions

Weight Loss Change Examined in Healthy Low-Fat vs. Healthy Low-Carb Diet

February 21, 2018

The researchers found that the mean 12-month macronutrient distributions were 48 versus 30% for carbohydrates, 29 versus 45% for fat, and 21 versus 23% for protein in the HLF versus HLC diets. At 12 months, weight change was −5.3 and −6.0 kg for the HLF and HLC diet.