Metabolic Disorders

Infant Gut Microbiota May Mediate Intergenerational Transmission of Obesity

February 22, 2018

The researchers found that infants born vaginally to overweight or obese mothers were significantly more likely to become overweight at age 1 year, compared with being born vaginally to a normal-weight mother (adjusted odds ratio, 3.33).

Obese Individuals May Have Greater Metastatic Melanoma Survival Odds

February 21, 2018

The obesity-related survival benefit was seen only for patients receiving targeted therapy (hazard ratios, 0.72 and 0.6 for progression-free and overall survival, respectively) and immunotherapy (hazard ratios, 0.75 and 0.64, respectively), not for patients receiving chemotherapy.

USPSTF: Obese Patients Should Be Referred to Multicomponent Behavioral Interventions

February 21, 2018

Draft recommendation statement concludes that doctors should provide, refer adults to interventions

Weight Loss Change Examined in Healthy Low-Fat vs. Healthy Low-Carb Diet

February 21, 2018

The researchers found that the mean 12-month macronutrient distributions were 48 versus 30% for carbohydrates, 29 versus 45% for fat, and 21 versus 23% for protein in the HLF versus HLC diets. At 12 months, weight change was −5.3 and −6.0 kg for the HLF and HLC diet.

Endocrine Disruptors Linked to Greater Weight Regain, Especially in Women

February 14, 2018

Higher baseline levels of PFAS tied to greater weight regain in weight-loss setting, especially for women

Addressing Sensitive Topics With Patients: An Interview With Windel Stracener, MD

By February 14, 2018

"Patients must feel that you are empathetic and do not judge them. This is key not only to discussing weight, but to any subject that comes up," said Dr Windel Stracener, a family practitioner for 22 years.

Cystic Fibrosis Combo Treatment Symdeko Gets FDA Approval

By February 13, 2018

Symdeko is Vertex's third medicine approved to treat the underlying cause of CF.

Teva Makes Generic Syprine Available for Treating Wilson's Disease

By February 09, 2018

Trientine hydrochloride is only indicated for use when penicillamine is no longer possible because of intolerability or life endangering side effects.

Breastfeeding May Impact Maternal Hypertension Risk

February 09, 2018

Findings among Korean women evaluated for hypertension at postmenopausal age. Similarly, greater obesity and insulin resistance significantly weakened the protective effects of having breastfed for longer.

Year-Long School Fitness Program Shows No Difference in Child BMI

February 08, 2018

No significant reduction in BMI z score at 15 or 30 months of healthy lifestyle program intervention.

'Gene Silencing' Drug Under FDA Review for Hereditary ATTR Amyloidosis

By February 02, 2018

Patisiran has been granted Fast Track Designation, Breakthrough Therapy Designation, and an expanded Orphan Drug Designation for ATTR amyloidosis from the FDA.

Weight Loss Could Improve Chronic Pain Among Obese Patients

January 29, 2018

A total of 123 obese individuals underwent a 12- to 16-week weight loss intervention with calorie restriction.

Obesity and Prostate CA Recurrence: What's the Link?

January 26, 2018

The researchers found that there were more obese patients in the high- versus low-/intermediate-risk group (41.2 versus 32.0%; P=0.006).

Weight Loss and Regain Examined After Weight Management Intervention

January 24, 2018

Individuals began to regain 0.07kg/week after 77.66 days. At 222.55 days, the rate of regain decreased slightly to 0.06kg/week.

Greater Pediatric, Public Health Interaction Needed for Failing Child Care

January 23, 2018

Pediatricians and public health professionals frequently interact to the benefit of children and their families; however, increasing integration of the two disciplines is critical for improving child health.

Targeting Sleep Hygiene May Combat Obesity

January 22, 2018

Attrition was 6.5%, and compliance was 85.7%. The researchers found that, compared with the control group, the sleep extension group had significantly increased time in bed (55 minutes), sleep period (47 minutes), and sleep duration (21 minutes).

Weight Loss Difference Between Lap Sleeve Gastrectomy, RYGB Examined

January 17, 2018

The researchers found that the estimated mean percentage weight loss at five years was 49 and 57% after sleeve gastrectomy and gastric bypass, respectively.

Change in CVD Risk Factors Analyzed Following Bariatric Sx

January 10, 2018

The researchers found that increasing weight loss independently predicted normalization in dyslipidemia, elevated blood pressure, hyperinsulinemia, diabetes, and elevated high-sensitivity C-reactive protein.

Following Gastric Bypass, Nature of β-Cell Sensitivity May Change

December 11, 2017

During the highest dose of glucose infusion, the GB subjects had relative hyperglycemia associated with significantly reduced β-cell glucose sensitivity throughout both step-up

Link Between Obesity and Rosacea Examined for First Time

December 11, 2017

The risk for rosacea was higher among those with increased body mass index (BMI; P<0.0001).

Early Treatment With Kalydeco Investigated in Young Cystic Fibrosis Patients

By December 08, 2017

Sweat chloride, a diagnostic characteristic of CF, was also considerably reduced with ivacaftor treatment. Median baseline sweat chloride levels were 104.1mmol/L.

Seven Year Weight Loss Examined for Roux-en-Y, Laparoscopic Bariatric Sx

December 07, 2017

The researchers found that the mean weight loss was 38.2kg or 28.4% of baseline weight at 7 years after RYGB; mean weight regain was 3.9% between years 3 and 7.

Obesity Tied to All-Cause Mortality in HF With Preserved Ejection Fraction

November 28, 2017

Data were included for 3,310 patients with HFpEF: 2,413 with abdominal obesity and 897 patients without abdominal obesity.

Cinnamon May Activate Thermogenesis, Help Combat Obesity

November 27, 2017

The researchers found that in murine primary adipocytes, CA significantly activated PKA signaling, increased expression levels of thermogenic genes, and induced phosphorylation of hormone-sensitive lipase and protein perilipin 1.

Mepsevii Approved to Treat Rare Genetic Disease

By November 16, 2017

Mepsevii (vestronidase alfa-vjbk) was evaluated by the FDA with Priority Review.

CPAP vs. Gastric Band for Severe Sleep Apnea

November 09, 2017

The researchers found that LGB was associated with a greater drop in BMI. In intention-to-treat analyses, the effective apnea-hypopnea index (AHI) at nine months was 29.5 and 20 events/hour in the LGB and CPAP groups, respectively (P=0.02), while at 18 months, the effective AHI was 20.9 and 21.4 events/hour, respectively.

Tezacaftor-Ivacaftor, Ivacaftor Monotherapy Examined in Cystic Fibrosis

November 07, 2017

The researchers found that the effects on the absolute and relative changes in the percentage of the predicted FEV1 were 4 and 6.8%, respectively, in favor of tezacaftor-ivacaftor over placebo.

Elevated GLP-1 After Gastric Bypass May Improve Satiety

November 02, 2017

After Roux-en-Y, CNS activation reduced in response to food cues, GLP-1 levels significantly elevated We hypothesized that postoperative elevated GLP-1 levels contribute to the improved satiety regulation after RYGB via effects on the CNS.

Obesity Treatments

October 27, 2017

A comparative list of medications by pharmacological class for the treatment of obesity.

Probiotic Use Linked to Weight Reduction in Obese and Overweight Patients

October 27, 2017

The researchers found that, compared with placebo, probiotic administration resulted in a significantly larger reduction in body weight, BMI, and fat percentage.