Menopause And HRT

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

March 28, 2018

No residual effect for past users, including early discontinuers of menopause hormone treatment

Impact of Menopausal Hormone Tx on Cognition Assessed 3-Years Post Treatment

March 22, 2018

The longitudinal decline in dorsolateral prefrontal cortex volumes was less in the tE2 group compared with the placebo group. In the menopausal hormone therapy groups, the rates of global cognitive change did not differ from that of the placebo group.

Efficacy of Moisturizer, Estradiol Tablets Examined in Treating Vulvovaginal Symptoms

March 20, 2018

Similar reductions were seen for most bothersome symptom severity for all treatment groups over 12 weeks (estradiol, −1.4; moisturizer, −1.2; and placebo, −1.3).

Abaloparatide Followed by Alendronate Ups BMD in Postmenopausal Women

By March 19, 2018

At the 43-month endpoint, a total of 60.7% (307/506) of the abaloparatide followed by alendronate group had ≥3% increase in bone mass at all 3 sites (P<0.0001) vs. 24% (121/505) of the placebo followed by alendronate group.

FDA Accepts NDA for Bio-Identical Combination Hormone Therapy

By March 09, 2018

TX-001HR is an investigational treatment for moderate-to-severe vasomotor symptoms due to menopause.

Product Defect Leads to Recall of Hormone Replacement Therapy

By March 05, 2018

The recall was initiated due to a manufacturing defect.

Menopausal Hormone Therapy May Aid in Reducing Spine Injury

February 23, 2018

The researchers found that, compared with never-users of HT, continuous users had a mean Cobb angle that was 4.0 degrees less, in minimally-adjusted models (P=0.01); in fully-adjusted models, the correlation was attenuated to 2.8 degrees (P=0.06).

Number of Children, Age at First Birth May Contribute to Higher CVD Risk in Women

January 16, 2018

For CVD, adjusted hazard ratios of 1.16 and 2.30 were seen for hysterectomy without oophorectomy or with previous oophorectomy, respectively.

Drug-Free Supplements Launched for Menopause Symptom Relief

By December 15, 2017

The drug-free supplements also contain varying levels of flax, vitamin B2, vitamin B6, D-biotin, and vitamin D3.

USPSTF Updates Recommendation on Menopausal Hormone Therapy

December 12, 2017

Based on these findings, the USPSTF concluded that for most postmenopausal women with an intact uterus, combined estrogen and progestin had no net benefit for primary prevention of chronic conditions (D recommendation).

Postmenopausal Estradiol May Protect Against Effects of Stress

November 03, 2017

The researchers found that the women assigned to estradiol exhibited blunted cortisol responses to CPT compared with the women in the placebo group (P=0.017) and lesser negative effects of stress on working memory (P=0.048).

CombiPatch, Minivelle Patches No Longer in Shortage

By October 03, 2017

Noven announced that CombiPatch (estradiol/norethindrone acetate transdermal system) and Minivelle (estradiol transdermal system) are now readily available following a temporary product shortage.

Hormone Tx During Menopause and Mortality Rate: Is There a Link?

September 13, 2017

The researchers found that during the 18-year follow-up, there were 7,489 deaths (1,088 deaths during the intervention phase and 6,401 deaths during postintervention follow-up).

Non-Hormone Options Recommended for Depletion After Breast CA

August 30, 2017

The researchers recommend that women should not generally be treated with menopausal hormone therapy or tibolone following breast cancer, but should optimize lifestyle.

Licorice Supplements May Put Patients at Risk for Drug Interactions

By August 22, 2017

More women are looking toward alternatives like licorice due to, "concerns about the risk of stroke and breast cancer associated with conventional hormone," said Richard B. van Breemen, PhD, and lead author.

Cancer, CV Risks Examined for Vaginal Estrogen Tx in Postmenopausal Women

By August 16, 2017

The data showed women with an intact uterus did not have a significantly different risk of stroke, invasive breast cancer, colorectal cancer, endometrial cancer, and pulmonary embolism/deep vein thrombosis (PE/DVT) between those who used vaginal estrogen and those who did not.

Teva Launches Generic Vagifem

By July 26, 2017

Local estrogen therapy has been shown to restore vaginal pH and resvascularize the vaginal and urethral mucosa, improving vaginal dryness and mucosal atrophy.

Novel Treatment for Dyspareunia Due to Menopause Now Available

By July 24, 2017

Intrarosa contains prasterone, an inactive precursor that is converted locally into estrogens and androgens (with minimal systemic exposure) to help restore vaginal tissue.

Can Estrogen Exposure Affect Depression Risk in Early Post Menopausal Years?

July 24, 2017

Researchers included 1,306 regularly menstruating premenopausal women, aged 42 to 52 years at study entry

NAMS: New Position Statement on Hormone Therapy

By June 20, 2017

Firstly, NAMS reiterates that HT should be individualized for each patient and requires periodic reevaluation for risks and benefits of selected therapy.

Higher Alcohol Intake May Up Muscle Loss, Function for Some Women

By June 07, 2017

The data showed sarcopenia was 4 times more prevalent for the high-risk alcohol drinking group vs. the low-risk alcohol drinking group (odds ratio 4.29, 95% CI: 1.87, 9.82).

Menopausal Age May Correlate With Heart Failure Risk, Incidence

May 16, 2017

The investigators found that earlier menopause was associated with increased risk of heart failure, and this link was stronger in women who had natural rather than surgical menopause.

HRT May Up Hearing Loss Risk in Postmenopausal Women

May 16, 2017

Older age at menopause also appears to increase the risk

Early Hot Flashes May Indicate Presence of Comorbidities

April 17, 2017

The researchers found the associations of hot flashes to be independent of other cardiovascular disease risk factors.

Bio-Identical Combo Therapy Promising for Vasomotor Symptoms of Menopause

By April 04, 2017

TherapeuticsMD announced positive data for its investigational hormone therapy, TX-001HR, for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause. Study findings were presented at the annual meeting of the Endocrine Society, ENDO 2017.

Neurokinin 3 Receptor Antagonism for Menopausal Hot Flushes

By April 03, 2017

Prague JK, et al. "Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial"

Estriol Gel Investigated Post-Genital Prolapse Sx

March 31, 2017

The researchers found that the group receiving estriol gel had improvement in all aspects of vaginal health before surgery versus baseline .

Vit D Levels May Correlate With Overall Survival in Breast CA

By March 24, 2017

The researchers found that the overall survival was strongest among premenopausal women in the highest 25OHD tertile group.

Hormone Therapy and Alzheimer's Disease: What's the Link?

February 17, 2017

Researchers found that their evidence showed no protective association between postmenopausal HT use and AD or dementia, although they observed a reduced AD risk among those with long-term self-reported HT use.

Certain Pain Meds May Have Significant Endocrinologic Effects

By February 10, 2017

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone (fTe) and free estradiol (fE2), highlighting the potential endocrinologic side effects of these drugs. These were the findings of a new study published in the journal Drug Testing and Analysis.