Melanoma And Other Skin Cancers
The researchers found that in the overall intention-to-treat population, pembrolizumab correlated with significantly longer recurrence-free survival than placebo at a median follow-up of 15 months.
"Few indoor tanners (ITs) have been screened for skin cancer, although skin cancer (SC) rates are higher than among non-tanners," the authors write. "It is not surprising that SC screening is associated with SC risk factors (e.g., family history of SC and age) among ITs."
Behavioral interventions increase sun protection behavior but do not reduce sunburn or skin cancer outcomes.
Based on these findings, in order to reduce the risk of skin cancer, the USPSTF recommends counseling regarding minimizing exposure to ultraviolet radiation for those aged 6 months to 24 years with fair skin types (B recommendation).
The researchers found that 34.2% of participants experienced sunburn in 2015. The prevalence was higher among younger age groups (51.2% for those aged 18 to 29 years) and in non-Hispanic whites and those with sun-sensitive skin (42.5 and 50.2%, respectively).
The researchers found that tanning addiction was positively associated with being female, not being in a relationship, extroversion, neuroticism, anxiety, and obsessive-compulsiveness. New Screening Tool Developed to Assess Tanning Addiction
Compared with mice colonized with a control S. epidermidis strain that did not produce 6-HAP, colonization of mice with a 6-HAP-producing strain reduced the incidence of ultraviolet-induced tumors. Multiple healthy human subjects had S. epidermidis strains producing 6-HAP.
The researchers found that 25.3% of the lesions were MIS. The most frequent dermoscopic criteria for MIS were regression, atypical network, and irregular dots and/or globules (92.9, 85.5, and 50.2%, respectively).
The obesity-related survival benefit was seen only for patients receiving targeted therapy (hazard ratios, 0.72 and 0.6 for progression-free and overall survival, respectively) and immunotherapy (hazard ratios, 0.75 and 0.64, respectively), not for patients receiving chemotherapy.
Parent sex, parent indoor tanning use, and adolescents' skin reactivity were associated with perceiving high indoor tanning benefits.
The guidelines address biopsy techniques and histopathologic assessment, staging of tumors, surgical and nonsurgical management, follow-up, prevention of recurrence, and advanced disease management.
The percentage of PD-L1-positive cells was higher in the tumor parenchyma in desmoplastic melanomas than in non-desmoplastic melanomas (P=0.04).
The major efficacy outcome measure was RFS, defined as the time between the randomization date and the date of first recurrence (local, regional, or distant metastasis), new primary melanoma, or death from any cause, whichever occurs first.
The researchers found that ulixertinib exposure was dose-proportional to the RP2D and almost completely inhibited ERK activity in whole blood.
SCC was revealed accompanying AC in 14 patients in postoperative biopsy; four patients in the AC-only group had SCC in situ.
Gorlin Syndrome is a rare, genetic disease characterized by mutations in the tumor suppressor gene encoding Patched1.
The researchers recommend that clinicians provide counseling on sun protection behaviors for anyone with fair skin aged 6 months to 24 years, including parents of young children with fair skin (B recommendation).
The researchers found that the use of propranolol at the time of diagnosis was significantly inversely linked to melanoma recurrence after adjustment for known prognostic factors, with about an 80% reduction in risk for propranolol users.
The researchers found that the estimated 3-year rate of relapse-free survival was 58% in the combination-therapy group and 39% in the placebo group at a median follow-up of 2.8 years.
The researchers found that the 12-month rate of recurrence-free survival was 70.5 and 60.8% in the nivolumab and ipilimumab groups, respectively, at a minimum follow-up of 18 months.
The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.
A Phase 2, single-arm, open-label clinical trial, EMPOWER-CSCC 1, is now enrolling patients with metastatic CSCC and locally advanced and unresectable CSCC.
The researchers found that, as determined by the cell viability assay, ultraviolet (UV)-induced keratinocyte death was attenuated by myricetin in a dose-dependent manner.
A population pharmacokinetic analysis (n=565) showed that Yervoy exposure in patients aged ≥12 years was similar to that in adults at the approved 3mg/kg dose given intravenously (IV) over 90 minutes every 3 weeks for a total of doses.
Compared to controls, the researchers found that male mice consuming red tomato diets or pooled tomato diets had significantly lower tumor number (1.73 ± 0.50 and 2.03 ± 0.45, respectively, versus 4.04 ± 0.65).
The researchers found that, compared with controls, patients with Parkinson's disease had a 3.8-fold increased likelihood of having preexisting melanoma, while patients with melanoma had a 4.2-fold increased risk of developing Parkinson's disease.
The researchers found that 58% of the 526 randomized patients experienced disease progression, including 28 and 72% in the TBP and non-TBP groups.