Melanoma And Other Skin Cancers

Available Vial Sizes Can Cut Drug Waste in Weight-Based Dosing

January 03, 2019

Pharmaceutical vial fill volumes can be optimized to reduce drug wastage when dosing is calculated by patient weight or body surface area, according to a new study.

Keytruda Gains Merkel Cell Carcinoma Indication

By December 20, 2018

The Food and Drug Administration has granted accelerated approval to Keytruda (pembrolizumab; Merck) for the treatment of patients with recurrent locally advanced or metastatic Merkel cell carcinoma.

Wearable Sensor Can Measure Personalized Ultraviolet Exposure

December 13, 2018

A millimeter-scale, wireless, battery-free, miniaturized dosimeter can monitor ultraviolet (UV) radiation exposure and appears to work well in different settings.

First Treatment for Advanced Cutaneous Squamous Cell Carcinoma FDA-Approved

By October 01, 2018

The approval was based on data from 2 open-label studies where patients with metastatic CSCC or locally advanced CSCC who were not candidates for curative surgery or curative radiation received Libtayo 3mg/kg intravenously every 2 weeks for up to 48 weeks or up to 96 weeks until disease progression, unacceptable toxicity, or completion of planned treatment.

Long-Term Outcomes of Breast Implants Explored

September 24, 2018

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

Review: Treatments for Primary Basal Cell Carcinoma Compared

September 18, 2018

Compared with excision or cryotherapy, for phototherapy using methyl-aminolevulinic acid or aminolevulinic acid there was a higher proportion of patients reporting good or better cosmetic outcomes (93.8 and 95.8, respectively, versus 77.8 and 51.1%, respectively).

Keytruda Gets Priority Review for Merkel Cell Carcinoma Indication

By September 04, 2018

Merkel cell carcinoma is a rare form of skin cancer associated with higher mortality rates than other skin cancers.

HPV Vaccine Eliminates Advanced Skin Cancer in 97-Year-Old

July 24, 2018

Doctors tried an unorthodox approach - injecting each tumor with Gardasil, the HPV vaccine. The result: All the tumors completely and rapidly disappeared.

Researchers Develop First Blood Test for Melanoma

July 19, 2018

The researchers identified a combination of 10 autoantibody biomarkers that, as a panel, displayed a sensitivity, specificity, and an area under the curve of 79%, 84%, and 0.828, respectively, for primary melanoma detection.

Patient Interest Fairly High for Melanoma Genetic Risk Testing

July 10, 2018

The researchers found that 232 of the 499 participants randomized to MC1R testing logged on to the website, and of these, 88% (204 participants) requested testing and 82% (167 participants) returned the test kit.

New Guidelines Increase Melanoma Staging Reproducibility

June 28, 2018

The researchers found that for T1a diagnoses, participating pathologists' concordance with the consensus reference diagnosis increased from 44% with AJCC 7 criteria to 54% with AJCC 8 criteria.

FDA Approves Combination Therapy for Advanced BRAF-Mutant Melanoma

By June 27, 2018

The approval of these kinase inhibitors was supported by data from the Phase 3, randomized, active-controlled, open-label, multicenter COLUMBUS trial (N=577).

Higher Rates of Cancers Observed Among Flight Attendants

June 27, 2018

Especially breast cancer, melanoma, and non-melanoma skin cancer among female flight attendants

Skin Cancer Examinations More Likely for Indoor Tanning Users

June 07, 2018

Overall, 75.3% of users and 55.4% of non-users reported having performed an SSE. Fewer people reported having had a PSE, but examinations were more common among indoor tanning bed users versus non-users (60 versus 40.1%).

Immune Checkpoint Inhibitor Efficacy Varies by Sex

May 17, 2018

The researchers found that, compared with men treated in control groups, the pooled overall survival hazard ratio was 0.72 for male patients treated with immune checkpoint inhibitors.

Teledermatology Could Expedite Care for Suspected Skin Cancer

May 14, 2018

The researchers found that the mean time to clinical resolution was 9 days with teledermoscopy referral, compared with 35 days with usual care alone.

Chronic Aspirin Exposure Linked to Melanoma Risk in Males

May 09, 2018

After stratification by gender, a significant correlation was seen for aspirin exposure and melanoma diagnosis among males (adjusted relative risk, 1.83; 95% confidence interval, 1.22 to 2.76; P=.004), but not females (adjusted relative risk, 0.53; 95% confidence interval, 0.17 to 1.63; P=.266).

Tafinlar + Mekinist Approved for Adjuvant Tx of Melanoma With BRAF V600 Mutation

By May 01, 2018

Approval was based on COMBI-AD, an international, multi-center, randomized, double-blind, placebo-controlled trial in 870 patients with Stage III melanoma with BRAF V600E or V600K mutations, and pathologic involvement of regional lymph node(s).

Knowledge Not Tied to Addictive Tanning Behavior in Millennials

April 27, 2018

Furthermore, motivation for perceived appearance enhancement was a significant predictor of addictive tanning behavior. The correlation between narcissism and additive tanning was mediated by appearance motivation.

Adjuvant Pembrolizumab May be Beneficial in Stage III Melanoma

April 16, 2018

The researchers found that in the overall intention-to-treat population, pembrolizumab correlated with significantly longer recurrence-free survival than placebo at a median follow-up of 15 months.

Few Indoor Tanners Have Been Screened for Skin Cancer

April 05, 2018

"Few indoor tanners (ITs) have been screened for skin cancer, although skin cancer (SC) rates are higher than among non-tanners," the authors write. "It is not surprising that SC screening is associated with SC risk factors (e.g., family history of SC and age) among ITs."

Links Between Hydrochlorothiazide and Non-Melanoma Skin CA Examined

March 22, 2018

High use of hydrochlorothiazide (≥50,000mg) was associated with basal cell carcinoma and squamous cell carcinoma.

USPSTF: Fair-Skin Youths Should be Counselled on Minimizing UV Exposure

March 21, 2018

Based on these findings, in order to reduce the risk of skin cancer, the USPSTF recommends counseling regarding minimizing exposure to ultraviolet radiation for those aged 6 months to 24 years with fair skin types (B recommendation).

High Prevalence of Sunburn in U.S. Highlights Need for Targeted Prevention

March 15, 2018

The researchers found that 34.2% of participants experienced sunburn in 2015. The prevalence was higher among younger age groups (51.2% for those aged 18 to 29 years) and in non-Hispanic whites and those with sun-sensitive skin (42.5 and 50.2%, respectively).

FDA Approves New Dosing Option for Opdivo

By March 06, 2018

This approval will provide healthcare professionals the flexibility to customize patient care.

New Scale May Help Identify Patients Addicted to Tanning

March 05, 2018

The researchers found that tanning addiction was positively associated with being female, not being in a relationship, extroversion, neuroticism, anxiety, and obsessive-compulsiveness. New Screening Tool Developed to Assess Tanning Addiction

The Skin Bacteria That Could Inhibit Melanoma Growth

March 01, 2018

Compared with mice colonized with a control S. epidermidis strain that did not produce 6-HAP, colonization of mice with a 6-HAP-producing strain reduced the incidence of ultraviolet-induced tumors. Multiple healthy human subjects had S. epidermidis strains producing 6-HAP.

Dermoscopic Criteria Accuracy Assessed in Diagnosing Melanoma in Situ

February 23, 2018

The researchers found that 25.3% of the lesions were MIS. The most frequent dermoscopic criteria for MIS were regression, atypical network, and irregular dots and/or globules (92.9, 85.5, and 50.2%, respectively).

Obese Individuals May Have Greater Metastatic Melanoma Survival Odds

February 21, 2018

The obesity-related survival benefit was seen only for patients receiving targeted therapy (hazard ratios, 0.72 and 0.6 for progression-free and overall survival, respectively) and immunotherapy (hazard ratios, 0.75 and 0.64, respectively), not for patients receiving chemotherapy.

Parental Awareness Lacking for Dangers of Indoor Tanning

February 20, 2018

Parent sex, parent indoor tanning use, and adolescents' skin reactivity were associated with perceiving high indoor tanning benefits.