VTE Risk Up with Low Gestational Age, Through Young Adulthood
the MPR take:
Although an increased risk of venous thromboembolism (VTE) in infancy has been linked to preterm birth in previous studies, the risk through young adulthood has not been fully explored. In a new study in the journal Pediatrics, a Swedish national cohort of 3,571,574 individuals, including 206,844 individuals born preterm (gestational age <37 weeks), who were born between 1973–2008 were followed-up through 2010 regarding confirmed VTE diagnosis. Low gestational weight at birth was associated with a greater risk of VTE in infancy, early childhood (ages 1–5) and young adulthood (ages 18–38 years), but not late childhood (ages 6–12 years). Individuals born very preterm (<34 weeks) also had a greater VTE risk in adolescence (13–17 years). Particularly for those born very preterm, the increased risk of VTE should be considered by treating pediatricians and specialists, if applicable.
BACKGROUND: Preterm birth has been associated with increased risk of venous thromboembolism (VTE) in infancy, but the longer-term risk is unknown. Our aim was to examine this association from birth through young adulthood.METHODS: National cohort study of 3 571 574 individuals who were live-born in Sweden from 1973 through 2008, including 206 844 born preterm (gestational age <37 weeks), and followed up to 2010 (ages 0-38 years).
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