Troponin: Prognostic Value in CKD Without ACS, Studies Suggest
(HealthDay News) — For patients with chronic kidney disease (CKD) without suspected acute coronary syndrome (ACS), troponin levels may have prognostic and diagnostic value, according to two reviews published online Aug. 12 in the Annals of Internal Medicine.
Erin D. Michos, MD, MHS, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues conducted a systematic review of 98 observational studies to examine the prognostic value of troponin for patients with CKD without ACS. The researchers found that, among patients receiving dialysis, elevated troponin levels correlated with all-cause and cardiovascular mortality. After adjustment for age and coronary artery disease or a risk equivalent, the pooled hazard ratios for all-cause and cardiovascular mortality were 3.0 and 3.3, respectively, for elevated troponin T and 2.7 and 4.2, respectively, for elevated troponin I.
Sylvie R. Stacy, MD, MPH, from the Johns Hopkins University Bloomberg School of Public Health in Baltimore, and colleagues conducted a systematic review involving 23 studies to assess the utility of troponin in ACS diagnosis in patients with CKD with suspected ACS. The researchers found that, for ACS diagnosis, the sensitivity and specificity of troponin T ranged from 71–100% and from 31–86%, respectively. For troponin I, the sensitivity and specificity ranged from 43–94% and from 48–100%, respectively. Elevated troponin I or troponin T levels correlated with increased risk of short-term death and cardiac events.
"Researchers should continue to try to determine optimal cut points for troponin levels in various patient populations and test management strategies based on these levels," write the authors of an accompanying editorial.