Slight Risk of Congenital Defects Tied to Parents' Celiac Disease
(HealthDay News) — There is a slight increased risk for congenital malformation among the offspring of mothers or fathers with celiac disease, according to a study published in the July issue of Clinical Gastroenterology and Hepatology.
Daniela Zugna, from the University of Turin in Italy, and colleagues analyzed data from linked health care registers in Sweden (1973–2009) to identify individuals with celiac disease (based on the presence of villous atrophy on pathological examination).
The researchers found that among 11,382 offspring of mothers with celiac disease, there were 672 cases (5.9%) of malformation compared with 2,098 cases (5.1%) among 40,922 offspring of mothers without celiac disease. Similar results were seen for offspring of fathers with/without celiac disease. The offspring of mothers or fathers with celiac disease had a slightly increased risk of having children with malformations in adjusted analysis (with maternal history: adjusted prevalence odds ratios [aPOR], 1.15; 95% confidence interval (CI), 1.05–1.26; for paternal history: aPOR, 1.14; 95% CI, 1.00–1.29), however, these excess risks decreased or vanished entirely when examining data for births since 2000 (for maternal history: aPOR, 1.11; 95% CI, 0.79–1.56; for paternal history: aPOR, 1.01; 95% CI, 0.81–1.26).
"The excess risk is small; the upper limits of the CIs for malformation indicate a 29% maximum relative increase," the authors write.