Sleep Apnea Severity Linked to Glycated Hemoglobin Levels
(HealthDay News) – For adults without diabetes, obstructive sleep apnea (OSA) severity is independently associated with impaired glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels.
Pascaline Priou, MD, of LUNAM University in Angers, France, and colleagues conducted a large cross-sectional study involving 1,599 patients with OSA. HbA1c levels were measured, and patients with diabetes, use of diabetes medications, or HbA1c levels ≥6.5% were excluded.
The researchers found that HbA1c levels increased with increasing OSA severity, as measured by the apnea-hypopnea index (AHI), with the percent of patients with HbA1c increasing from 10.8 to 34.2% for those with AHI values <5–≥50, respectively. After adjusting for potential confounding factors, the odds ratios of a patient having an HbA1c level >6% increased from 1.0 (reference) for AHI <5; to 1.40 for AHI of ≥5–<15; to 1.8 for AHI of ≥15–<30; to 2.02 for AHI of ≥30–<50; to 2.96 for AHI of ≥50. Additionally, an independent association was found between increasing hypoxemia during sleep and the odds of an elevated HbA1c level.
"Among adults without known diabetes, increasing OSA severity is independently associated with impaired glucose metabolism, as assessed by higher HbA1c values, which may expose them to higher risks of diabetes and cardiovascular disease," the authors write.