Rheumatoid Arthritis Risk Surges for Smokers Consuming Too Much Salt
the MPR take:
While moderate sodium consumption is recommended for all, current smokers may want to limit their intake based on the results of a new study linking smoking and sodium to an increased risk of developing rheumatoid arthritis (RA). Using information from a Swedish community health screening program, the dietary habits prior to RA symptom onset in 386 individuals were reviewed, with a mean of 7.7 years of dietary data available. While no significant association was seen between sodium intake and development of RA, a higher sodium intake more than doubled the RA risk among smokers (odds ratio (OR) 2.26 [95% CI 1.06, 4.81]).Those consuming the greatest amount of sodium had a 54% higher risk of developing RA compared to non-smokers with low sodium intake. While smoking cessation should be recommended for all patients, it is advised that patients with existing risk factors for RA be counseled on nutrition and smoking cessation therapies by clinicians.
Objective: Recent studies in animal models and on human cells have shown an effect of sodium chloride (NaCl) on Th17 cells promoting inflammation. The aim of this study was to evaluate the impact of NaCl intake on the risk of development of RA.
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